Pneumatically actuated microvalve circuits for programmable automation of chemical and biochemical analysis.

Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices--a new device is needed to implement each new chemical or biochemical assay. PMPs are analogous to digital electronic processors--all that is needed to implement a new assay is a change in the order of operations conducted by the device. In this review, we introduce PMPs based on normally-closed microvalves. We discuss recent applications of PMPs in diverse fields including genetic analysis, antibody-based biomarker analysis, and chemical analysis in planetary exploration. Prospects, challenges, and future concepts for this emerging technology will also be presented.

[1]  Young Jin Choi,et al.  A novel polydimethylsiloxane microfluidic system including thermopneumatic-actuated micropump and Paraffin-actuated microvalve , 2007 .

[2]  R. Mathies,et al.  Enhanced amine and amino acid analysis using Pacific Blue and the Mars Organic Analyzer microchip capillary electrophoresis system. , 2009, Analytical chemistry.

[3]  J. Michael Ramsey,et al.  Minimizing the number of voltage sources and fluid reservoirs for electrokinetic valving in microfluidic devices. , 1999, Analytical chemistry.

[4]  Marcio G von Muhlen,et al.  Teflon films for chemically-inert microfluidic valves and pumps. , 2008, Lab on a chip.

[5]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[6]  R. Mathies,et al.  Capillary electrophoresis analysis of organic amines and amino acids in saline and acidic samples using the Mars organic analyzer. , 2009, Astrobiology.

[7]  Veronica Sanchez-Freire,et al.  Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns , 2012, Nature Protocols.

[8]  S. Quake,et al.  Single-Molecule DNA Sequencing of a Viral Genome , 2008, Science.

[9]  Richard A Mathies,et al.  An integrated microfluidic processor for single nucleotide polymorphism-based DNA computing. , 2005, Lab on a chip.

[10]  Bozhi Yang,et al.  A latchable microvalve using phase change of paraffin wax , 2007 .

[11]  Philip N Duncan,et al.  Pneumatic oscillator circuits for timing and control of integrated microfluidics , 2013, Proceedings of the National Academy of Sciences.

[12]  Philip N Duncan,et al.  Scaling of pneumatic digital logic circuits. , 2015, Lab on a chip.

[13]  L. N. Matveeva,et al.  The missing organic molecules on Mars. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Bruce C. Towe,et al.  A miniature shape memory alloy pinch valve , 1999 .

[15]  Masayoshi Esashi,et al.  Microflow devices and systems , 1994 .

[16]  Wanjun Wang,et al.  Design and fabrication of an electrochemically actuated microvalve , 2008 .

[17]  Yan Xu,et al.  Helicase‐dependent isothermal DNA amplification , 2004, EMBO reports.

[18]  William H. Grover,et al.  Development and multiplexed control of latching pneumatic valves using microfluidic logical structures. , 2006, Lab on a chip.

[19]  R. Mathies,et al.  Analysis of carbonaceous biomarkers with the Mars Organic Analyzer microchip capillary electrophoresis system: Aldehydes and ketones , 2010, Electrophoresis.

[20]  R. Mathies,et al.  PMMA/PDMS valves and pumps for disposable microfluidics. , 2009, Lab on a chip.

[21]  Jens Anders Branebjerg,et al.  Microfluidics-a review , 1993 .

[22]  R. Mathies,et al.  Integration of programmable microfluidics and on-chip fluorescence detection for biosensing applications. , 2014, Biomicrofluidics.

[23]  Jungkyu Kim,et al.  Digitally programmable microfluidic automaton for multiscale combinatorial mixing and sample processing. , 2013, Lab on a chip.

[24]  R. Mathies,et al.  Analysis of carbonaceous biomarkers with the Mars Organic Analyzer microchip capillary electrophoresis system: carboxylic acids. , 2011, Astrobiology.

[25]  Erik C Jensen,et al.  Universal microfluidic automaton for autonomous sample processing: application to the Mars Organic Analyzer. , 2013, Analytical chemistry.

[26]  Numrin Thaitrong,et al.  Integrated microfluidic bioprocessor for single-cell gene expression analysis , 2008, Proceedings of the National Academy of Sciences.

[27]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[28]  G. Whitesides,et al.  Torque-actuated valves for microfluidics. , 2005, Analytical chemistry.

[29]  Govind V Kaigala,et al.  Electrically controlled microvalves to integrate microchip polymerase chain reaction and capillary electrophoresis. , 2008, Lab on a chip.

[30]  George M Whitesides,et al.  Pumping fluids in microfluidic systems using the elastic deformation of poly(dimethylsiloxane). , 2007, Lab on a chip.

[31]  D. Beebe,et al.  The present and future role of microfluidics in biomedical research , 2014, Nature.

[32]  Stephen R Quake,et al.  Solving the "world-to-chip" interface problem with a microfluidic matrix. , 2003, Analytical chemistry.

[33]  P. Willis,et al.  Low-temperature microchip nonaqueous capillary electrophoresis of aliphatic primary amines: applications to Titan chemistry. , 2013, Analytical chemistry.

[34]  Ismail Emre Araci,et al.  Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves. , 2012, Lab on a chip.

[35]  Stephen R Quake,et al.  Whole-genome molecular haplotyping of single cells , 2011, Nature Biotechnology.

[36]  Gi Hun Seong,et al.  Microfluidic chips for immunoassays. , 2013, Annual review of analytical chemistry.

[37]  G. Stemme,et al.  A Low-Temperature Thermopneumatic Actuation Principle for Gas Bubble Microvalves , 2007, Journal of Microelectromechanical Systems.

[38]  William H. Grover,et al.  Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Erik C Jensen,et al.  A digital microfluidic platform for the automation of quantitative biomolecular assays. , 2010, Lab on a chip.

[40]  P. Willis,et al.  Analysis of thiols by microchip capillary electrophoresis for in situ planetary investigations , 2013, Electrophoresis.

[41]  William H. Grover,et al.  Micropneumatic Digital Logic Structures for Integrated Microdevice Computation and Control , 2007, Journal of Microelectromechanical Systems.

[42]  Richard A Mathies,et al.  Multichannel capillary electrophoresis microdevice and instrumentation for in situ planetary analysis of organic molecules and biomarkers. , 2010, Analytical chemistry.

[43]  Mehmet Toner,et al.  Cell handling using microstructured membranes. , 2006, Lab on a chip.

[44]  Vincent Studer,et al.  Scaling properties of a low-actuation pressure microfluidic valve , 2004 .

[45]  R. Schasfoort,et al.  Field-effect flow control for microfabricated fluidic networks , 1999, Science.

[46]  Rashid Bashir,et al.  BioMEMS: state-of-the-art in detection, opportunities and prospects. , 2004, Advanced drug delivery reviews.

[47]  R. Mathies,et al.  Polycyclic aromatic hydrocarbon analysis with the Mars organic analyzer microchip capillary electrophoresis system. , 2009, Analytical chemistry.

[48]  Ryutaro Maeda,et al.  A pneumatically-actuated three-way microvalve fabricated with polydimethylsiloxane using the membrane transfer technique , 2000 .

[49]  R. Mathies,et al.  Integrated microfluidic systems for high-performance genetic analysis. , 2009, Trends in biotechnology.

[50]  Wen Dai,et al.  Whole-Teflon microfluidic chips , 2011, Proceedings of the National Academy of Sciences.

[51]  W. Marsden.  I and J , 2012 .

[52]  Jungkyu Kim,et al.  Microvalve Enabled Digital Microfluidic Systems for High-Performance Biochemical and Genetic Analysis , 2010, JALA.

[53]  Sophia Adamia,et al.  An adaptable microvalving system for on-chip polymerase chain reactions. , 2005, Journal of immunological methods.

[54]  Jan H. J. Fluitman,et al.  Towards integrated microliquid handling systems , 1994 .

[55]  William H. Grover,et al.  Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices , 2003 .

[56]  Dmitry Pushkarev,et al.  Single-molecule sequencing of an individual human genome , 2009, Nature Biotechnology.

[57]  Stephen R. Quake,et al.  Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm , 2012, Cell.

[58]  Jessica Melin,et al.  Microfluidic large-scale integration: the evolution of design rules for biological automation. , 2007, Annual review of biophysics and biomolecular structure.

[59]  Stephen R. Quake,et al.  Microfluidic Digital PCR Enables Multigene Analysis of Individual Environmental Bacteria , 2006, Science.

[60]  Richard Novak,et al.  Rapid fabrication of nickel molds for prototyping embossed plastic microfluidic devices. , 2013, Lab on a chip.

[61]  Richard A Mathies,et al.  Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing. , 2006, Proceedings of the National Academy of Sciences of the United States of America.