EMUDRA: Ensemble of Multiple Drug Repositioning Approaches to improve prediction accuracy
暂无分享,去创建一个
Bin Zhang | Minghui Wang | Xianxiao Zhou | Igor Katsyv | Hanna Irie | Bin Zhang | Minghui Wang | Xianxiao Zhou | H. Irie | I. Katsyv | Igor Katsyv
[1] Jianhua Lu,et al. Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer. , 2014, Oncology reports.
[2] Shu-Dong Zhang,et al. sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures , 2009, BMC Bioinformatics.
[3] Nita Ahuja,et al. Phase 2 study investigating the safety, efficacy, and surrogate biomarkers of response to 5-azacitidine (5-AZA) and entinostat in advanced breast cancer. , 2014 .
[4] B. Trink,et al. Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells , 2012, Apoptosis.
[5] Yan Jie,et al. Molecular mechanism of trifluoperazine induces apoptosis in human A549 lung adenocarcinoma cell lines. , 2009, Molecular medicine reports.
[6] Pankaj Agarwal,et al. Systematic evaluation of connectivity map for disease indications , 2014, Genome Medicine.
[7] R. Tagliaferri,et al. Discovery of drug mode of action and drug repositioning from transcriptional responses , 2010, Proceedings of the National Academy of Sciences.
[8] Matthew R Trendowski,et al. Using Cytochalasins to Improve Current Chemotherapeutic Approaches , 2015, Anti-cancer agents in medicinal chemistry.
[9] Stuart L Schreiber,et al. Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening. , 2007, Chemistry & biology.
[10] Alexander A. Morgan,et al. Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease , 2011, Science Translational Medicine.
[11] M. Nobre,et al. Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer , 2016, Journal of oncology.
[12] Mårten Fryknäs,et al. Iron chelators target both proliferating and quiescent cancer cells , 2016, Scientific Reports.
[13] Yeun Kyu Jang,et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.
[14] Marc Peeters,et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. , 2015, The New England journal of medicine.
[15] Peer Bork,et al. Drug-Induced Regulation of Target Expression , 2010, PLoS Comput. Biol..
[16] L. Tran,et al. Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.
[17] Michalis V. Karamouzis,et al. Superior efficacy of the antifungal agent ciclopirox olamine over gemcitabine in pancreatic cancer models , 2017, Oncotarget.
[18] Avi Ma'ayan,et al. Drug-induced adverse events prediction with the LINCS L1000 data , 2016, Bioinform..
[19] Rafael A Irizarry,et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.
[20] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumors , 2012, Nature.
[21] Chiun-Sheng Huang,et al. Bevacizumab Preconditioning Followed by Etoposide and Cisplatin Is Highly Effective in Treating Brain Metastases of Breast Cancer Progressing from Whole-Brain Radiotherapy , 2015, Clinical Cancer Research.
[22] Edith Filaire,et al. Study of the Effects of Betaine and/or C-Phycocyanin on the Growth of Lung Cancer A549 Cells In Vitro and In Vivo , 2016, Journal of oncology.
[23] JiangJingwen,et al. Trifluoperazine Activates FOXO1-Related Signals to Inhibit Tumor Growth in Hepatocellular Carcinoma , 2017 .
[24] Y. Benjamini,et al. THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .
[25] Paul A. Townsend,et al. Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction , 2015, Oncotarget.
[26] Daniele Naviglio,et al. The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time? , 2017, Journal of cellular physiology.
[27] Omgo E. Nieweg,et al. Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial , 2018, Oncoimmunology.
[28] Seungmin Kang,et al. Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures , 2016, PloS one.
[29] István Láng,et al. Low-dose oral cyclophosphamide-methotrexate maintenance (CMM) for receptor-negative early breast cancer (BC). , 2015 .
[30] Michael J. Keiser,et al. Predicting new molecular targets for known drugs , 2009, Nature.
[31] Peer Bork,et al. Discovery and validation of the antimetastatic activity of citalopram in colorectal cancer , 2015, Molecular & cellular oncology.
[32] Rui Liu,et al. Pyrvinium targets autophagy addiction to promote cancer cell death , 2013, Cell Death and Disease.
[33] Jie Cheng,et al. Comparing gene expression similarity metrics for connectivity map , 2013, 2013 IEEE International Conference on Bioinformatics and Biomedicine.
[34] Paul A Clemons,et al. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease , 2006, Science.
[35] Cheng-Yan Kao,et al. Gene Expression-Based Chemical Genomics Identifies Potential Therapeutic Drugs in Hepatocellular Carcinoma , 2011, PloS one.
[36] P. Bork,et al. Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. , 2014, Cancer research.
[37] E. Ruppin,et al. Drugs that reverse disease transcriptomic signatures are more effective in a mouse model of dyslipidemia , 2015 .
[38] Xavier Robin,et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves , 2011, BMC Bioinformatics.
[39] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumours , 2013 .
[40] K. Reddy,et al. Triple-negative breast cancers: an updated review on treatment options. , 2011, Current oncology.
[41] Takashi Inui,et al. MEK and PI3K catalytic activity as predictor of the response to molecularly targeted agents in triple-negative breast cancer. , 2017, Biochemical and biophysical research communications.
[42] M. Ashburner,et al. Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.
[43] Matthew E. Ritchie,et al. limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.
[44] Shu-Dong Zhang,et al. A simple and robust method for connecting small-molecule drugs using gene-expression signatures , 2008, BMC Bioinformatics.
[45] R. Shields,et al. mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass , 2011, Cell metabolism.
[46] Jean YH Yang,et al. Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.
[47] Yuetong Wang,et al. Ethacrynic Acid Oxadiazole Analogs Induce Apoptosis in Malignant Hematologic Cells through Downregulation of Mcl-1 and c-FLIP, Which Was Attenuated by GSTP1-1 , 2013, Molecular Cancer Therapeutics.
[48] Amirhossein Sahebkar,et al. The novel role of pyrvinium in cancer therapy , 2018, Journal of cellular physiology.
[49] Shin-Cheh Chen,et al. Identification of patients with node-negative, triple-negative breast cancer who benefit from adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy. , 2014, Anticancer research.
[50] Y-Y Hsieh,et al. Repositioning of a cyclin-dependent kinase inhibitor GW8510 as a ribonucleotide reductase M2 inhibitor to treat human colorectal cancer , 2016, Cell Death Discovery.
[51] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[52] Sean R. Davis,et al. NCBI GEO: archive for functional genomics data sets—update , 2012, Nucleic Acids Res..
[53] Leslie Cope,et al. Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study , 2016, Clinical Cancer Research.
[54] Amar Koleti,et al. Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS) , 2014, Journal of biomolecular screening.