CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.
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R. Zhai | Hui-Chen Lu | Y. Ali | M. Ljungberg | K. Oka | Chia-Shan Wu | Jie Zhu | M. Cecilia Ljungberg | R. Grace Zhai | M. C. Ljungberg | Chia Shan Wu | R. G. Zhai
[1] N. Martin,et al. Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations. , 2012, Human molecular genetics.
[2] K. Ashe,et al. Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration , 2010, Neuron.
[3] A. Caccamo,et al. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease , 2010, Alzheimer's & Dementia.
[4] J. Milbrandt,et al. Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons* , 2010, The Journal of Biological Chemistry.
[5] Daniel R. Dries,et al. Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2* , 2010, The Journal of Biological Chemistry.
[6] E. Mandelkow,et al. Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines , 2010, The Journal of Neuroscience.
[7] Jürgen Götz,et al. Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models , 2010, Cell.
[8] A. Lleó,et al. β-Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1 , 2010, The Journal of Neuroscience.
[9] M. Freeman,et al. Wallerian degeneration, wld(s), and nmnat. , 2010, Annual review of neuroscience.
[10] A. Barco,et al. CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models , 2010, Trends in Neurosciences.
[11] R. Luján,et al. Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function , 2010, Cell Death and Differentiation.
[12] B. Hyman,et al. Caspase activation precedes and leads to tangles , 2010, Nature.
[13] Tara Spires-Jones,et al. Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation , 2010, The Journal of Neuroscience.
[14] Q. Zhai,et al. Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity , 2010, Neurochemistry International.
[15] J. Gilley,et al. Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons , 2010, PLoS biology.
[16] Xiaomin Song,et al. Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice , 2009, Proceedings of the National Academy of Sciences.
[17] O. Arancio,et al. Reversal of long-term dendritic spine alterations in Alzheimer disease models , 2009, Proceedings of the National Academy of Sciences.
[18] J. Milbrandt,et al. Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo , 2009, The Journal of Neuroscience.
[19] R. Zhai,et al. Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme , 2009, Cellular and Molecular Life Sciences.
[20] T. Araki,et al. Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration , 2009, The Journal of Neuroscience.
[21] N. Leclerc,et al. Increased Association Between Rough Endoplasmic Reticulum Membranes and Mitochondria in Transgenic Mice That Express P301L Tau , 2009, Journal of neuropathology and experimental neurology.
[22] Alcino J. Silva,et al. The molecular and cellular biology of enhanced cognition , 2009, Nature Reviews Neuroscience.
[23] J. Milbrandt,et al. Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress , 2008, The Journal of Neuroscience.
[24] P. Hiesinger,et al. NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration , 2008, Nature.
[25] B. Teter,et al. Evidence of Aβ‐ and transgene‐dependent defects in ERK‐CREB signaling in Alzheimer’s models , 2007, Journal of neurochemistry.
[26] Xingguo Cheng,et al. Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression , 2007, Molecular Pharmacology.
[27] M. Ziegler,et al. The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. , 2007, The Biochemical journal.
[28] S. Kügler,et al. Long-term rescue of a lethal inherited disease by adeno-associated virus-mediated gene transfer in a mouse model of molybdenum-cofactor deficiency. , 2007, American journal of human genetics.
[29] Bin Zhang,et al. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.
[30] Sunil Q. Mehta,et al. Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis Activity , 2006, PLoS biology.
[31] J. Grieger,et al. Production and characterization of adeno-associated viral vectors , 2006, Nature Protocols.
[32] J. Hell. Faculty Opinions recommendation of Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. , 2006 .
[33] O. Vitolo,et al. Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory , 2006, Cell.
[34] M. K. Pflum,et al. Cyclic AMP response element-binding protein (CREB) and CAAT/enhancer-binding protein beta (C/EBPbeta) bind chimeric DNA sites with high affinity. , 2006, Biochemistry.
[35] Richard A Young,et al. Chromatin immunoprecipitation and microarray-based analysis of protein location , 2006, Nature Protocols.
[36] M. Freeman,et al. The Drosophila Cell Corpse Engulfment Receptor Draper Mediates Glial Clearance of Severed Axons , 2006, Neuron.
[37] B. Hyman,et al. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. , 2006, The American journal of pathology.
[38] K. Ashe,et al. Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L) , 2005, The Journal of Neuroscience.
[39] M. Ziegler,et al. Subcellular Compartmentation and Differential Catalytic Properties of the Three Human Nicotinamide Mononucleotide Adenylyltransferase Isoforms* , 2005, Journal of Biological Chemistry.
[40] Bertrand Z. Yeung,et al. Vulnerability of Dentate Granule Cells to Disruption of Arc Expression in Human Amyloid Precursor Protein Transgenic Mice , 2005, The Journal of Neuroscience.
[41] W. Gu,et al. A local mechanism mediates NAD-dependent protection of axon degeneration , 2005, The Journal of cell biology.
[42] B. Hyman,et al. Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function , 2005, Science.
[43] R. Mandel,et al. Recombinant adeno-associated viral vectors in the nervous system. , 2005, Human gene therapy.
[44] R. Ravid,et al. Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice* , 2005, Journal of Biological Chemistry.
[45] P. Hof,et al. Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms , 2005, The Journal of Neuroscience.
[46] Richard G. Jenner,et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[47] Michel Goedert,et al. Mutations causing neurodegenerative tauopathies. , 2005, Biochimica et biophysica acta.
[48] V. Arolt,et al. S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury , 2004, Neuroscience.
[49] Gail Mandel,et al. Defining the CREB Regulon A Genome-Wide Analysis of Transcription Factor Regulatory Regions , 2004, Cell.
[50] Hitoshi Osaka,et al. The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. , 2004, Brain : a journal of neurology.
[51] R. Samulski,et al. Integration of adeno-associated virus (AAV) and recombinant AAV vectors. , 2004, Annual review of genetics.
[52] J. Milbrandt,et al. Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration , 2004, Science.
[53] C. Cotman,et al. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. , 2004, The Journal of clinical investigation.
[54] E. Kandel,et al. Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration , 2004, Neuron.
[55] G. Magni,et al. Structure and function of nicotinamide mononucleotide adenylyltransferase. , 2004, Current medicinal chemistry.
[56] P. Aebischer,et al. Wlds-Mediated Protection of Dopaminergic Fibers in an Animal Model of Parkinson Disease , 2004, Current Biology.
[57] J. Brotchi,et al. Recombinant AAV‐mediated gene delivery to the central nervous system , 2004, The journal of gene medicine.
[58] R. Ribchester,et al. Neuroprotection after Transient Global Cerebral Ischemia in Wlds Mutant Mice , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[59] J. Loeffler,et al. Critical loss of CBP/p300 histone acetylase activity by caspase‐6 during neurodegeneration , 2003, The EMBO journal.
[60] F. LaFerla,et al. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer’s disease , 2003, Neurobiology of Aging.
[61] D. Dickson,et al. Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau , 2003, Journal of neurocytology.
[62] Haruhiko Bito,et al. Ca(2+)/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival. , 2003, Cell calcium.
[63] P. Davies,et al. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms , 2003, Journal of neurochemistry.
[64] M. Mattson,et al. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction , 2003, Neuron.
[65] R. Berry,et al. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[66] Jacob Raber,et al. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[67] J. Loring,et al. Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice , 2003, The Journal of Neuroscience.
[68] M. Kay,et al. Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. , 2003, Molecular therapy : the journal of the American Society of Gene Therapy.
[69] N. Grishin,et al. Structural Characterization of a Human Cytosolic NMN/NaMN Adenylyltransferase and Implication in Human NAD Biosynthesis* 210 , 2003, The Journal of Biological Chemistry.
[70] G. Magni,et al. Identification of a novel human nicotinamide mononucleotide adenylyltransferase. , 2002, Biochemical and biophysical research communications.
[71] O. Vitolo,et al. Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[72] N. Philpott,et al. A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[73] D. Ginty,et al. Function and Regulation of CREB Family Transcription Factors in the Nervous System , 2002, Neuron.
[74] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[75] V. Perry,et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene , 2001, Nature Neuroscience.
[76] Marc Montminy,et al. Transcriptional regulation by the phosphorylation-dependent factor CREB , 2001, Nature Reviews Molecular Cell Biology.
[77] Joshua M. Shulman,et al. Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles , 2001, Science.
[78] R. Balázs,et al. β-Amyloid-(1–42) Impairs Activity-dependent cAMP-response Element-binding Protein Signaling in Neurons at Concentrations in Which Cell Survival Is Not Compromised* , 2001, The Journal of Biological Chemistry.
[79] M. Desco,et al. P300 amplitude as a possible correlate of frontal degeneration in schizophrenia , 2001, Schizophrenia Research.
[80] G. Schellenberg,et al. Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. , 2001, Archives of neurology.
[81] G. Magni,et al. Molecular Cloning, Chromosomal Localization, Tissue mRNA Levels, Bacterial Expression, and Enzymatic Properties of Human NMN Adenylyltransferase* , 2001, The Journal of Biological Chemistry.
[82] R. Nitsch,et al. Tau Filament Formation in Transgenic Mice Expressing P301L Tau* , 2001, The Journal of Biological Chemistry.
[83] V. Perry,et al. A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[84] Wen-Lang Lin,et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein , 2000, Nature Genetics.
[85] M. Hutton. Molecular genetics of chromosome 17 tauopathies , 2000, Neurobiology of Aging.
[86] S. Reske,et al. FTDP‐17: An early‐onset phenotype with parkinsonism and epileptic seizures caused by a novel mutation , 1999, Annals of neurology.
[87] M G Spillantini,et al. Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. , 1999, Journal of neuropathology and experimental neurology.
[88] B. Byrne,et al. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield , 1999, Gene Therapy.
[89] P. Riederer,et al. Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type , 1999, Brain Research.
[90] M. Goedert,et al. Tau protein pathology in neurodegenerative diseases , 1998, Trends in Neurosciences.
[91] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[92] A. Means,et al. Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[93] J. Morley,et al. Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor. , 1992, European journal of pharmacology.
[94] John F. Disterhoft,et al. Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine , 1992, Nature.
[95] M. Greenberg,et al. CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. , 1991, Science.
[96] Samulski,et al. Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression , 1989, Journal of virology.
[97] V. Perry,et al. Absence of Wallerian Degeneration does not Hinder Regeneration in Peripheral Nerve , 1989, The European journal of neuroscience.
[98] J. Daly,et al. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[99] M. Ziegler,et al. The NMN/NaMN adenylyltransferase (NMNAT) protein family. , 2009, Frontiers in bioscience.
[100] C. Alberini,et al. Transcription factors in long-term memory and synaptic plasticity. , 2009, Physiological reviews.
[101] C. Brenner,et al. NAD+ metabolism in health and disease. , 2007, Trends in biochemical sciences.
[102] Wolfgang Schmid,et al. Disruption of CREB function in brain leads to neurodegeneration , 2002, Nature Genetics.
[103] J. Trojanowski,et al. Neurodegenerative tauopathies. , 2001, Annual review of neuroscience.