Ictal Perfusion Patterns Associated with Single MRI‐Visible Focal Dysplastic Lesions: Implications for the Noninvasive Delineation of the Epileptogenic Zone

Summary:  Background: Invasive electroencephalogram (EEG) studies are often considered necessary to localize the epileptogenic zone in partial epilepsies associated with focal dysplastic lesions (FDL). Our aim was to evaluate the relationships between subtraction ictal SPECT coregistered with magnetic resonance imaging (MRI) (SISCOM) hyperperfusion clusters and MRI‐visible FDL, and to establish a preliminary algorithm for a noninvasive presurgical evaluation protocol for MRI‐visible FDLs in patients with refractory epilepsy.

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