Mitochondria-targeted phosphorescent cyclometalated iridium(III) complexes: synthesis, characterization, and anticancer properties

[1]  L. Ji,et al.  Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. , 2019, Journal of inorganic biochemistry.

[2]  Qianling Zhang,et al.  Recent advances in lysosome-targeting luminescent transition metal complexes , 2019, Coordination Chemistry Reviews.

[3]  P. Sadler,et al.  Targeted photoredox catalysis in cancer cells , 2019, Nature Chemistry.

[4]  Zi-jian Zhao,et al.  A mitochondria-targeted iridium(iii)-based photoacid generator induces dual-mode photodynamic damage within cancer cells. , 2019, Chemical communications.

[5]  Z. Mao,et al.  Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(i) complex. , 2019, Dalton transactions.

[6]  Yuliang Yang,et al.  Fluorescent half-sandwich phosphine-sulfonate iridium(III) and ruthenium(II) complexes as potential lysosome-targeted anticancer agents , 2019, Dyes and Pigments.

[7]  L. Ji,et al.  Anticancer Cyclometalated Iridium(III) Complexes with Planar Ligands: Mitochondrial DNA Damage and Metabolism Disturbance. , 2019, Journal of medicinal chemistry.

[8]  Yuliang Yang,et al.  Novel lysosome-targeted cyclometalated Iridium(III) anticancer complexes containing imine-N-heterocyclic carbene ligands: Synthesis, spectroscopic properties and biological activity , 2019, Dyes and Pigments.

[9]  L. Ji,et al.  Monitoring mitochondrial viscosity with anticancer phosphorescent Ir(iii) complexes via two-photon lifetime imaging , 2018, Chemical science.

[10]  Yuliang Yang,et al.  Novel and Versatile Imine-N-Heterocyclic Carbene Half-Sandwich Iridium(III) Complexes as Lysosome-Targeted Anticancer Agents. , 2018, Inorganic chemistry.

[11]  K. Y. Zhang,et al.  Dual-Phosphorescent Iridium(III) Complexes Extending Oxygen Sensing from Hypoxia to Hyperoxia. , 2018, Journal of the American Chemical Society.

[12]  L. Ji,et al.  Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo. , 2018, Dalton transactions.

[13]  Zhe-Sheng Chen,et al.  Oncosis-inducing cyclometalated iridium(iii) complexes , 2018, Chemical science.

[14]  Hui Chao,et al.  Organelle-targeting metal complexes: From molecular design to bio-applications , 2017, Coordination Chemistry Reviews.

[15]  P. Sadler,et al.  Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes† †Electronic supplementary information (ESI) available. CCDC 1522104. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03216a , 2017, Chemical science.

[16]  L. Ji,et al.  Cyclometalated iridium(iii) N-heterocyclic carbene complexes as potential mitochondrial anticancer and photodynamic agents. , 2017, Dalton transactions.

[17]  Sheng Lin,et al.  A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation. , 2017, Biosensors & bioelectronics.

[18]  Sheng Lin,et al.  Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound , 2017, Chemical science.

[19]  L. Ji,et al.  Light-Up Mitophagy in Live Cells with Dual-Functional Theranostic Phosphorescent Iridium(III) Complexes. , 2017, ACS applied materials & interfaces.

[20]  N. Bhuvanesh,et al.  Structural characterization, photophysical and BSA binding interaction studies of 4,4′-bis(benzimidazolyl)-2,2′-bipyridine , 2016, Journal of Structural Chemistry.

[21]  L. Ji,et al.  Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes† †Electronic supplementary information (ESI) available: Experimental procedures, figures and tables, references and X-ray crystallographic data. CCDC 1452036–1452038. For ESI and cryst , 2016, Chemical science.

[22]  J. Seo,et al.  Endoplasmic Reticulum-Localized Iridium(III) Complexes as Efficient Photodynamic Therapy Agents via Protein Modifications. , 2016, Journal of the American Chemical Society.

[23]  L. Ji,et al.  Coumarin-appended phosphorescent cyclometalated iridium(iii) complexes as mitochondria-targeted theranostic anticancer agents. , 2016, Dalton transactions.

[24]  A. Jemal,et al.  Cancer statistics in China, 2015 , 2016, CA: a cancer journal for clinicians.

[25]  C. S. Allardyce,et al.  Metal-based drugs that break the rules. , 2016, Dalton transactions.

[26]  Qiang Zhao,et al.  Phosphorescent soft salt for ratiometric and lifetime imaging of intracellular pH variations† †Electronic supplementary information (ESI) available: UV-visible spectrum, photoluminescence spectrum, 1H NMR spectra, MS spectra and cell imaging experiment. See DOI: 10.1039/c5sc04624f , 2016, Chemical science.

[27]  T. Lam,et al.  Stable luminescent iridium(iii) complexes with bis(N-heterocyclic carbene) ligands: photo-stability, excited state properties, visible-light-driven radical cyclization and CO2 reduction, and cellular imaging† †Electronic supplementary information (ESI) available: Additional experimental details, fig , 2016, Chemical science.

[28]  Heidi Ledford,et al.  The problem with platinum , 2015, Nature.

[29]  G. Gasser,et al.  Highly Charged Ruthenium(II) Polypyridyl Complexes as Lysosome-Localized Photosensitizers for Two-Photon Photodynamic Therapy. , 2015, Angewandte Chemie.

[30]  K. K. Lo,et al.  Functionalization of cyclometalated iridium( iii ) polypyridine complexes for the design of intracellular sensors, organelle-targeting imaging reagents, and metallodrugs , 2015 .

[31]  P. Sadler,et al.  Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design , 2015, Nature Communications.

[32]  Qiang Zhao,et al.  Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. , 2014, Angewandte Chemie.

[33]  L. Ji,et al.  Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium(II) complex. , 2014, Journal of medicinal chemistry.

[34]  L. Ji,et al.  Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. , 2014, Metallomics : integrated biometal science.

[35]  P. Sadler,et al.  The Potent Oxidant Anticancer Activity of Organoiridium Catalysts , 2014, Angewandte Chemie.

[36]  P. Sadler,et al.  Organoiridium Complexes: Anticancer Agents and Catalysts , 2014, Accounts of chemical research.

[37]  Chris C.S. Lau,et al.  Mitochondria-targeting cyclometalated iridium(III)-PEG complexes with tunable photodynamic activity. , 2013, Biomaterials.

[38]  D. Chan,et al.  Bioactive iridium and rhodium complexes as therapeutic agents , 2013 .

[39]  K. Y. Zhang,et al.  Cyclometalated iridium(III) polypyridine dibenzocyclooctyne complexes as the first phosphorescent bioorthogonal probes. , 2013, Chemical communications.

[40]  W. Chae,et al.  Synthetic control over photoinduced electron transfer in phosphorescence zinc sensors. , 2013, Journal of the American Chemical Society.

[41]  S. Lippard,et al.  Phosphorescent sensor for robust quantification of copper(II) ion. , 2011, Journal of the American Chemical Society.

[42]  Chunhui Huang,et al.  A nonemissive iridium(III) complex that specifically lights-up the nuclei of living cells. , 2011, Journal of the American Chemical Society.

[43]  Qiang Zhao,et al.  Phosphorescent heavy-metal complexes for bioimaging. , 2011, Chemical Society reviews.

[44]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[45]  A. Xu,et al.  Nuclear permeable ruthenium(II) β-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis. , 2010, Journal of medicinal chemistry.

[46]  L. Galluzzi,et al.  Targeting mitochondria for cancer therapy , 2010, Nature Reviews Drug Discovery.

[47]  C. Bagowski,et al.  Iridium complex with antiangiogenic properties. , 2010, Angewandte Chemie.

[48]  K. Y. Zhang,et al.  Structure, photophysical and electrochemical properties, biomolecular interactions, and intracellular uptake of luminescent cyclometalated iridium(III) dipyridoquinoxaline complexes. , 2010, Inorganic chemistry.

[49]  R. Schmidt,et al.  Mitochondrial DNA Depletion and Respiratory Chain Activity in Primary Human Subcutaneous Adipocytes Treated with Nucleoside Analogue Reverse Transcriptase Inhibitors , 2009, Antimicrobial Agents and Chemotherapy.

[50]  Peng Huang,et al.  Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.

[51]  Christian G Hartinger,et al.  Bioorganometallic chemistry--from teaching paradigms to medicinal applications. , 2009, Chemical Society reviews.

[52]  J. Barton,et al.  Mechanism of cellular uptake of a ruthenium polypyridyl complex. , 2008, Biochemistry.

[53]  Rebecca C Taylor,et al.  Apoptosis: controlled demolition at the cellular level , 2008, Nature Reviews Molecular Cell Biology.

[54]  S. Pieczenik,et al.  Mitochondrial dysfunction and molecular pathways of disease. , 2007, Experimental and molecular pathology.

[55]  Stephen J Lippard,et al.  Direct cellular responses to platinum-induced DNA damage. , 2007, Chemical reviews.

[56]  C. Reutelingsperger,et al.  Flow cytometry of apoptotic cell death. , 2000, Journal of immunological methods.

[57]  Alan G. Porter,et al.  Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis* , 1998, The Journal of Biological Chemistry.

[58]  L. Ji,et al.  Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. , 2015, Biomaterials.

[59]  P. Wipf,et al.  Targeting mitochondria. , 2008, Accounts of chemical research.