DIFFUSION MODELS OF MULTICOMPONENT MIXTURES IN THE LUNG

In this work, we are interested in two different diffusion models for multicomponent mixtures. We numerically recover experimental results underlining the inadequacy of the usual Fick diffusion model, and the importance of using the Maxwell-Stefan model in various situations. This model nonlinearly couples the mole fractions and the fluxes of each component of the mixture. We then consider a subregion of the lower part of the lung, in which we compare the two different models. We first recover the fact that the Fick model is enough to model usual air breathing. In the case of chronic obstructive bronchopneumopathies, a mixture of helium and oxygen is often used to improve a patient's situation. The Maxwell-Stefan model is then necessary to recover the experimental behaviour, and to observe the benefit for the patient, namely an oxygen peak.

[1]  Arthur C. Guyton,et al.  Comprar Guyton and Hall Textbook of Medical Physiology, 12th Edition | John E. Hall | 9781416045748 | Saunders , 2010 .

[2]  Francesco Salvarani,et al.  A mathematical and numerical analysis of the Maxwell-Stefan diffusion equations , 2012 .

[3]  Ross Taylor,et al.  Multicomponent mass transfer , 1993 .

[4]  V. Giovangigli Multicomponent flow modeling , 1999 .

[5]  Vincent Giovangigli,et al.  Convergent iterative methods for multicomponent diffusion , 1991, IMPACT Comput. Sci. Eng..

[6]  H. L. Toor,et al.  An experimental study of three component gas diffusion , 1962 .

[7]  PROJECTED ITERATIVE ALGORITHMS WITH APPLICATION TO MULTICOMPONENT TRANSPORT , 1997 .

[8]  R. Krishna,et al.  The Maxwell-Stefan approach to mass transfer , 1997 .

[9]  D. Leith,et al.  Gas Mixing and Distribution in the Lung , 1985 .

[10]  Bernard Sapoval,et al.  Smaller is better—but not too small: A physical scale for the design of the mammalian pulmonary acinus , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[11]  L E Farhi,et al.  Some implications of ternary diffusion in the lung. , 1975, Respiration physiology.

[12]  Ternary diffusion and effective diffusion coefficients in alveolar spaces. , 1980, Respiration physiology.

[13]  J. Westwater,et al.  The Mathematics of Diffusion. , 1957 .

[14]  A. Guyton,et al.  Textbook of Medical Physiology , 1961 .

[15]  R Takaki,et al.  A three-dimensional model of the human pulmonary acinus. , 2000, Journal of applied physiology.