A comparison between low‐dose (1 µg), standard‐dose (250 µg) ACTH stimulation tests and insulin tolerance test in the evaluation of hypothalamo–pituitary–adrenal axis in primary fibromyalgia syndrome

OBJECTIVE Primary fibromyalgia syndrome (PFS) is a nonarticular rheumatological syndrome characterized by disturbances in the hypothalamo–pituitary–adrenal (HPA) axis. The site of the defect in the HPA axis is a matter of debate. Our aim was to evaluate the HPA axis by the insulin‐tolerance test (ITT), standard dose (250 µg) ACTH test (SDT) and low dose (1 µg) ACTH test (LDT) in patients with PFS.

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