BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts

[1]  H. Aburatani,et al.  The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension , 2019, Science Signaling.

[2]  B. Brand-Saberi,et al.  Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones , 2019, bioRxiv.

[3]  G. Reilly,et al.  In vitro Models of Bone Remodelling and Associated Disorders , 2018, Front. Bioeng. Biotechnol..

[4]  B. Brand-Saberi,et al.  Murine transcription factor Math6 is a regulator of placenta development , 2018, Scientific Reports.

[5]  S. Murakami,et al.  BMPRIA is required for osteogenic differentiation and RANKL expression in adult bone marrow mesenchymal stromal cells , 2018, Scientific Reports.

[6]  K. Suchacki,et al.  Skeletal energy homeostasis: a paradigm of endocrine discovery. , 2017, The Journal of endocrinology.

[7]  H. Aburatani,et al.  BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors , 2016, Stem cell reports.

[8]  R. Gomis,et al.  Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8) , 2016, PloS one.

[9]  N. Kawao,et al.  Interactions Between Muscle Tissues and Bone Metabolism , 2015, Journal of cellular biochemistry.

[10]  M. Tegenthoff,et al.  ATOH8: a novel marker in human muscle fiber regeneration , 2015, Histochemistry and Cell Biology.

[11]  C. Theiss,et al.  Spatiotemporal expression of Math6 during mouse embryonic development , 2015, Histochemistry and Cell Biology.

[12]  M. Tegenthoff,et al.  ATOH8: a novel marker in human muscle fiber regeneration , 2014, Histochemistry and Cell Biology.

[13]  S. Maeda,et al.  Human Immunodeficiency Virus Type 1 Enhancer-binding Protein 3 Is Essential for the Expression of Asparagine-linked Glycosylation 2 in the Regulation of Osteoblast and Chondrocyte Differentiation* , 2014, The Journal of Biological Chemistry.

[14]  G. Zoidl,et al.  ATOH8, a regulator of skeletal myogenesis in the hypaxial myotome of the trunk , 2013, Histochemistry and Cell Biology.

[15]  R. Gomis,et al.  Characterization of the transcriptional activity of the basic helix-loop-helix (bHLH) transcription factor Atoh8. , 2013, Biochimica et biophysica acta.

[16]  B. Badran,et al.  Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. , 2013, World journal of stem cells.

[17]  M. Lu,et al.  The Transcription Factor Atonal homolog 8 Regulates Gata4 and Friend of Gata-2 during Vertebrate Development , 2013, The Journal of Biological Chemistry.

[18]  W. Tawackoli,et al.  BMP-6 is more efficient in bone formation than BMP-2 when overexpressed in mesenchymal stem cells , 2012, Gene Therapy.

[19]  Kosaku Kurata,et al.  Evidence for osteocyte regulation of bone homeostasis through RANKL expression , 2011, Nature Medicine.

[20]  K. Ying,et al.  Diversification and Molecular Evolution of ATOH8, a Gene Encoding a bHLH Transcription Factor , 2011, PloS one.

[21]  Shuichi Tsutsumi,et al.  ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif , 2011, Nucleic acids research.

[22]  L. Hocking,et al.  Bone remodelling at a glance , 2011, Journal of Cell Science.

[23]  Y. Miyamoto,et al.  Bone morphogenetic protein 2 enhances mouse osteoclast differentiation via increased levels of receptor activator of NF-κB ligand expression in osteoblasts , 2010, Cell and Tissue Research.

[24]  W. Jia,et al.  Atoh8, a bHLH Transcription Factor, Is Required for the Development of Retina and Skeletal Muscle in Zebrafish , 2010, PloS one.

[25]  J. Crockett,et al.  New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis , 2010, Osteoporosis International.

[26]  S. Khosla,et al.  Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate , 2008, Proceedings of the National Academy of Sciences.

[27]  D. J. Lucas,et al.  Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[28]  Y. Mishina,et al.  BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway , 2008, Development.

[29]  N. Sims,et al.  Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption. , 2008, Seminars in cell & developmental biology.

[30]  R. Gomis,et al.  Identification of the bHLH Factor Math6 as a Novel Component of the Embryonic Pancreas Transcriptional Network , 2008, PloS one.

[31]  L. Xing,et al.  Functions of RANKL/RANK/OPG in bone modeling and remodeling. , 2008, Archives of biochemistry and biophysics.

[32]  Koichi Matsuo,et al.  Osteoclast-osteoblast communication. , 2008, Archives of biochemistry and biophysics.

[33]  Li-Wei Chang,et al.  Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers , 2007, The EMBO journal.

[34]  S. Akira,et al.  CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Regulates Osteoblast Differentiation , 2006, Molecular and Cellular Biology.

[35]  G. Stein,et al.  Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription , 2005, Journal of cellular physiology.

[36]  Bart O. Williams,et al.  Essential Role of β-Catenin in Postnatal Bone Acquisition* , 2005, Journal of Biological Chemistry.

[37]  K. Miyazono,et al.  BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk. , 2005, Cytokine & growth factor reviews.

[38]  R. Behringer,et al.  Bone Morphogenetic Protein Type IA Receptor Signaling Regulates Postnatal Osteoblast Function and Bone Remodeling* , 2004, Journal of Biological Chemistry.

[39]  M. Justice,et al.  A twist code determines the onset of osteoblast differentiation. , 2004, Developmental cell.

[40]  M. Goumans,et al.  Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells , 2004, The EMBO journal.

[41]  S. Teitelbaum,et al.  Enrichment of generated murine osteoclasts , 1994, Calcified Tissue International.

[42]  John A Latham,et al.  Osteocyte control of bone formation via sclerostin, a novel BMP antagonist , 2003, The EMBO journal.

[43]  T. Takizawa,et al.  Enhanced gene activation by Notch and BMP signaling cross-talk. , 2003, Nucleic acids research.

[44]  R. Fukuyama,et al.  Induction of Osteoclast Differentiation by Runx2 through Receptor Activator of Nuclear Factor-κB Ligand (RANKL) and Osteoprotegerin Regulation and Partial Rescue of Osteoclastogenesis in Runx2–/– Mice by RANKL Transgene* , 2003, Journal of Biological Chemistry.

[45]  G. Xiao,et al.  Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways , 2003, Journal of cellular biochemistry.

[46]  S. Bae,et al.  Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein , 2002, Oncogene.

[47]  A. Boyde,et al.  High Bone Resorption in Adult Aging Transgenic Mice Overexpressing Cbfa1/Runx2 in Cells of the Osteoblastic Lineage , 2002, Molecular and Cellular Biology.

[48]  P. ten Dijke,et al.  Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter* , 2002, The Journal of Biological Chemistry.

[49]  Y. Bessho,et al.  Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[50]  N. Kanatani,et al.  Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures , 2001, The Journal of cell biology.

[51]  G. Karsenty,et al.  The Mammalian Basic Helix Loop Helix Protein HES-1 Binds to and Modulates the Transactivating Function of the Runt-related Factor Cbfa1* , 2000, The Journal of Biological Chemistry.

[52]  A. Yamaguchi,et al.  Characterization of osteoblastic differentiation of stromal cell line ST2 that is induced by ascorbic acid. , 1999, The American journal of physiology.

[53]  G. Karsenty,et al.  A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. , 1999, Genes & development.

[54]  T. Komori,et al.  Cbfa1 Isoforms Exert Functional Differences in Osteoblast Differentiation* , 1999, The Journal of Biological Chemistry.

[55]  L. Xing,et al.  Recent advances in bone biology provide insight into the pathogenesis of bone diseases. , 1999, Laboratory investigation; a journal of technical methods and pathology.

[56]  Makoto Sato,et al.  Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.

[57]  V. Rosen,et al.  Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. , 1996, Biochemical and biophysical research communications.

[58]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.