Cu 2 O hollow microspheres as electrode materials for non‐enzymatic electrochemical detection of glucose

An enzyme-free glucose electrochemical sensor with high sensitivity and selectivity is highly attractive. In this work, an enzyme-free glucose sensor with Cu2O hollow microspheres (Cu2O HMs) was prepared via hydrothermal method. The glucose sensor constructed by the prepared Cu2O HM structure exhibited a low detection limit of 0.13 μM, a high sensitivity of 277.1 μA/mM cm2, and the wide linear ranges of 0.05–1.5 and 1.5–6.0 mM. Furthermore, anti-interference tests indicated that the prepared sensor exhibited good selectivity for glucose and practical application in human serum. The Cu2O sensor has great application potential in the development of enzyme-free glucose sensor.

[1]  Yanguang Li,et al.  Salt-templated growth of monodisperse hollow nanostructures , 2019, Journal of Materials Chemistry A.

[2]  Xiaobin Fan,et al.  Preparation of Cuprous Oxide Mesoporous Spheres with Different Pore Sizes for Non-Enzymatic Glucose Detection , 2018, Nanomaterials.

[3]  Yi Zhang,et al.  Fabrication of Z-Scheme Fe2O3–MoS2–Cu2O Ternary Nanofilm with Significantly Enhanced Photoelectrocatalytic Performance , 2018 .

[4]  Yujing Sun,et al.  Direct growth of pod-like Cu2O nanowire arrays on copper foam: Highly sensitive and efficient nonenzymatic glucose and H2O2 biosensor , 2016 .

[5]  Xiaojing Wang,et al.  Synthesis, Properties, and Applications of Hollow Micro-/Nanostructures. , 2016, Chemical reviews.

[6]  Ailing Yang,et al.  A non-enzymatic glucose sensing based on hollow cuprous oxide nanospheres in a Nafion matrix , 2015 .

[7]  Xiaoyan Yan,et al.  Size-controlled synthesis of Cu2O nanoparticles on reduced graphene oxide sheets and their application as non-enzymatic glucose sensor materials , 2015, Journal of Solid State Electrochemistry.

[8]  Hejun Li,et al.  Electrochemical sensing of ethylenediamine based on cuprous oxide/graphene hybrid structures , 2015, Journal of Materials Science.

[9]  Yunbin He,et al.  Synthesis of highly dispersed Pt nanoclusters anchored graphene composites and their application for non-enzymatic glucose sensing , 2015 .

[10]  Rafiq Ahmad,et al.  Glucose-assisted synthesis of Cu2O shuriken-like nanostructures and their application as nonenzymatic glucose biosensors , 2014 .

[11]  B. Raghupathy,et al.  Electrocatalytic activity of Cu2O nanocubes based electrode for glucose oxidation , 2014, Journal of Chemical Sciences.

[12]  Weihua Tang,et al.  Bimetallic PdCu nanoparticle decorated three-dimensional graphene hydrogel for non-enzymatic amperometric glucose sensor , 2014 .

[13]  Viviana Scognamiglio,et al.  Nanotechnology in glucose monitoring: advances and challenges in the last 10 years. , 2013, Biosensors & bioelectronics.

[14]  Wei Chen,et al.  Graphene wrapped Cu2O nanocubes: non-enzymatic electrochemical sensors for the detection of glucose and hydrogen peroxide with enhanced stability. , 2013, Biosensors & bioelectronics.

[15]  Cailing Xu,et al.  Non-enzymatic glucose sensor based on three dimensional nickel oxide for enhanced sensitivity , 2013 .

[16]  R. Amal,et al.  Embedment of anodized p-type Cu₂O thin films with CuO nanowires for improvement in photoelectrochemical stability. , 2013, Nanoscale.

[17]  Peng Si,et al.  Nanomaterials for electrochemical non-enzymatic glucose biosensors , 2013 .

[18]  Kai Jiang,et al.  Mesocrystalline Cu2O hollow nanocubes: synthesis and application in non-enzymatic amperometric detection of hydrogen peroxide and glucose , 2012 .

[19]  Xiangyang Wu,et al.  A ultrasensitive nonenzymatic glucose sensor based on Cu2O polyhedrons modified Cu electrode , 2012 .

[20]  Guo Gao,et al.  Facile synthesis of hollow Cu2O octahedral and spherical nanocrystals and their morphology-dependent photocatalytic properties , 2012, Nanoscale Research Letters.

[21]  M. Chan-Park,et al.  3D graphene-cobalt oxide electrode for high-performance supercapacitor and enzymeless glucose detection. , 2012, ACS nano.

[22]  Song Li,et al.  Enzyme-free amperometric sensing of hydrogen peroxide and glucose at a hierarchical Cu2O modified electrode. , 2011, Talanta.

[23]  Wei‐De Zhang,et al.  Fabrication of CuO nanoplatelets for highly sensitive enzyme-free determination of glucose , 2011 .

[24]  Kaiming Liao,et al.  Porous cuprous oxide microcubes for non-enzymatic amperometric hydrogen peroxide and glucose sensing , 2009 .

[25]  N. Mitro,et al.  The nuclear receptor LXR is a glucose sensor , 2007, Nature.

[26]  Sejin Park,et al.  Electrochemical non-enzymatic glucose sensors. , 2006, Analytica chimica acta.

[27]  Enbo Wang,et al.  A controllable synthetic route to Cu, Cu2O, and CuO nanotubes and nanorods. , 2003, Chemical communications.

[28]  Wenzhong Wang,et al.  Synthesis and Characterization of Cu2O Nanowires by a Novel Reduction Route , 2002 .