Small heterodimer partner attenuates profibrogenic features of hepatitis C virus‐infected cells

An atypical orphan nuclear receptor small heterodimer partner (SHP) is known to be regulated by AMP‐activated protein kinase (AMPK). Both of them inhibit TGF‐β and Smad signalling and exhibit antifibrotic activity in the liver. However, little is known about the protective effects of SHP and AMPK against hepatitis c virus (HCV)‐induced hepatic fibrosis.

[1]  T. Therneau,et al.  Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes , 2014, Hepatology.

[2]  D. Samuel,et al.  HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment. , 2013, Journal of hepatology.

[3]  Leiliang Zhang,et al.  The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling. , 2013, Journal of hepatology.

[4]  P. André,et al.  Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF‐β signaling , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  G. Waris,et al.  Activation of TGF-β1 Promoter by Hepatitis C Virus-Induced AP-1 and Sp1: Role of TGF-β1 in Hepatic Stellate Cell Activation and Invasion , 2013, PloS one.

[6]  K. Ghoshal,et al.  Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes , 2012, PloS one.

[7]  In-kyu Lee,et al.  Orphan Nuclear Receptor Small Heterodimer Partner Negatively Regulates Growth Hormone-mediated Induction of Hepatic Gluconeogenesis through Inhibition of Signal Transducer and Activator of Transcription 5 (STAT5) Transactivation* , 2012, The Journal of Biological Chemistry.

[8]  D. Brigstock,et al.  Regulation of hepatic stellate cells by connective tissue growth factor. , 2012, Frontiers in bioscience.

[9]  Y. H. Kim,et al.  Metformin ameliorates IL-6-induced hepatic insulin resistance via induction of orphan nuclear receptor small heterodimer partner (SHP) in mouse models , 2012, Diabetologia.

[10]  D. Moore,et al.  The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors , 2011, Nature Immunology.

[11]  E. Vicaut,et al.  Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients. , 2011, The Journal of clinical endocrinology and metabolism.

[12]  Leiliang Zhang,et al.  Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner. , 2010, Gastroenterology.

[13]  B. Viollet,et al.  Development of hepatic fibrosis occurs normally in AMPK-deficient mice. , 2010, Clinical science.

[14]  In-kyu Lee,et al.  The orphan nuclear receptor SHP attenuates renal fibrosis. , 2009, Journal of the American Society of Nephrology : JASN.

[15]  In-kyu Lee,et al.  Fenofibrate differentially regulates plasminogen activator inhibitor‐1 gene expression via adenosine monophosphate–activated protein kinase–dependent induction of orphan nuclear receptor small heterodimer partner , 2009, Hepatology.

[16]  A. Gressner,et al.  Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases , 2008, Liver international : official journal of the International Association for the Study of the Liver.

[17]  Hueng-Sik Choi,et al.  Molecular basis of endocrine regulation by orphan nuclear receptor Small Heterodimer Partner. , 2008, Endocrine journal.

[18]  In-kyu Lee,et al.  Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP , 2008, Diabetes.

[19]  S. Gelmini,et al.  Adenosine monophosphate–activated protein kinase modulates the activated phenotype of hepatic stellate cells , 2007, Hepatology.

[20]  Keesook Lee,et al.  Orphan Nuclear Receptor Small Heterodimer Partner Inhibits Transforming Growth Factor-β Signaling by Repressing SMAD3 Transactivation* , 2006, Journal of Biological Chemistry.

[21]  D. Schuppan,et al.  Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells. , 2005, Gastroenterology.

[22]  C. W. Kim,et al.  HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-β1 , 2005, Experimental & Molecular Medicine.

[23]  A. Morelli,et al.  The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. , 2004, Gastroenterology.

[24]  G. Davis,et al.  Projecting future complications of chronic hepatitis C in the United States , 2003, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[25]  D. Roulot,et al.  Transforming growth factor β and the liver , 2001 .

[26]  R. Schulte‐Hermann,et al.  Biology of transforming growth factor β in hepatocarcinogenesis , 2001, Microscopy research and technique.

[27]  L. Seeff,et al.  Natural history of hepatitis C , 1997, Hepatology.

[28]  P. Bedossa,et al.  Natural history of liver fibrosis progression in patients with chronic hepatitis C , 1997, The Lancet.

[29]  D. Moore,et al.  An Orphan Nuclear Hormone Receptor That Lacks a DNA Binding Domain and Heterodimerizes with Other Receptors , 1996, Science.

[30]  K. Batts,et al.  Chronic hepatitis. An update on terminology and reporting. , 1995, The American journal of surgical pathology.

[31]  D M Bissell,et al.  Transforming growth factor beta and the liver. , 2001, Hepatology.

[32]  R. W. Mccollum.  The natural history of hepatitis. , 1969, Bulletin of the New York Academy of Medicine.