Systematic review and meta‐analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery

Frailty is associated with poor prognosis, but the multitude of definitions and scales of assessment makes the impact on outcomes difficult to assess. The aim of this study was to quantify the effect of frailty on postoperative morbidity and mortality, and long‐term mortality after major abdominal surgery, and to evaluate the performance of different frailty metrics.

[1]  E. Finlayson,et al.  Frailty-Going From Measurement to Action. , 2017, JAMA surgery.

[2]  Christopher P. Filson,et al.  Patient Frailty and Discharge Disposition Following Radical Cystectomy , 2017, Clinical genitourinary cancer.

[3]  Tyler S. Wahl,et al.  Association of the Modified Frailty Index With 30-Day Surgical Readmission , 2017, JAMA surgery.

[4]  Khawaja H. Bilal,et al.  Modified frailty index associated with Clavien-Dindo IV complications in robot-assisted radical prostatectomies: A retrospective study. , 2017, Urologic oncology.

[5]  J. Dhesi,et al.  Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery , 2017, The British journal of surgery.

[6]  D. Manatakis,et al.  Fast-Track Pancreaticoduodenectomy in the Elderly , 2017, The American surgeon.

[7]  M. Braga,et al.  Enhanced Recovery Program in High-Risk Patients Undergoing Colorectal Surgery: Results from the PeriOperative Italian Society Registry , 2017, World Journal of Surgery.

[8]  N. Demartines,et al.  Enhanced recovery ERAS for elderly: a safe and beneficial pathway in colorectal surgery , 2017, International Journal of Colorectal Disease.

[9]  Rebecca M. Dodson,et al.  Modified Frailty Index Predicts Morbidity and Mortality After Pancreaticoduodenectomy , 2017, Annals of Surgical Oncology.

[10]  H. Wildiers,et al.  The impact of frailty on postoperative outcomes in individuals aged 65 and over undergoing elective surgery for colorectal cancer: A systematic review. , 2016, Journal of geriatric oncology.

[11]  F. Cianchi,et al.  Postoperative acute kidney injury in high-risk patients undergoing major abdominal surgery. , 2016, Journal of critical care.

[12]  M. Cooperberg,et al.  Impact of frailty on complications in patients undergoing common urological procedures: a study from the American College of Surgeons National Surgical Quality Improvement database , 2016, BJU international.

[13]  M. Makary,et al.  Inclusion of Sarcopenia Outperforms the Modified Frailty Index in Predicting 1-Year Mortality among 1,326 Patients Undergoing Gastrointestinal Surgery for a Malignant Indication. , 2016, Journal of the American College of Surgeons.

[14]  Matteo Cesari,et al.  Frailty: An Emerging Public Health Priority. , 2016, Journal of the American Medical Directors Association.

[15]  A. Neugut,et al.  Measurement and validation of frailty as a predictor of outcomes in women undergoing major gynaecological surgery , 2016, BJOG : an international journal of obstetrics and gynaecology.

[16]  H. Pitt,et al.  Relative Contributions of Complications and Failure to Rescue on Mortality in Older Patients Undergoing Pancreatectomy , 2016, Annals of surgery.

[17]  T. Pawlik,et al.  Clinical and morphometric parameters of frailty for prediction of mortality following hepatopancreaticobiliary surgery in the elderly , 2016, The British journal of surgery.

[18]  A. Roychoudhury,et al.  Validation of a frailty index in patients undergoing curative surgery for urologic malignancy and comparison with other risk stratification tools. , 2015, Urologic oncology.

[19]  E. Finlayson,et al.  Outcomes after ileoanal pouch surgery in frail and older adults. , 2015, The Journal of surgical research.

[20]  M. Barczyński,et al.  Cumulative deficit model of geriatric assessment to predict the postoperative outcomes of older patients with solid abdominal cancer. , 2015, Journal of geriatric oncology.

[21]  Sung-Won Kim,et al.  Prediction of Postoperative Complications Using Multidimensional Frailty Score in Older Female Cancer Patients with American Society of Anesthesiologists Physical Status Class 1 or 2. , 2015, Journal of the American College of Surgeons.

[22]  K. Roggin,et al.  Radiographic Sarcopenia and Self-reported Exhaustion Independently Predict NSQIP Serious Complications After Pancreaticoduodenectomy in Older Adults , 2015, Annals of Surgical Oncology.

[23]  P. Selby,et al.  The prevalence and outcomes of frailty in older cancer patients: a systematic review. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[24]  K. Ogan,et al.  Preoperative quantification of perceptions of surgical frailty. , 2015, The Journal of surgical research.

[25]  G. Kemp,et al.  Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. , 2015, British journal of anaesthesia.

[26]  N. Tangri,et al.  Frailty and perioperative outcomes: a narrative review , 2015, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

[27]  J. Lund,et al.  Simple psoas cross‐sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications , 2015, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[28]  E. Skovlund,et al.  Frailty is an independent predictor of survival in older patients with colorectal cancer. , 2014, The oncologist.

[29]  J. Nygren,et al.  Evidence or eminence in abdominal surgery: recent improvements in perioperative care. , 2014, World journal of gastroenterology.

[30]  M. Neuman,et al.  Can routine preoperative data predict adverse outcomes in the elderly? Development and validation of a simple risk model incorporating a chart-derived frailty score. , 2014, Journal of the American College of Surgeons.

[31]  Ho-Seong Han,et al.  Multidimensional frailty score for the prediction of postoperative mortality risk. , 2014, JAMA surgery.

[32]  S. Rose,et al.  Frailty index predicts severe complications in gynecologic oncology patients. , 2014, Gynecologic oncology.

[33]  Alaine M Kamm,et al.  Geriatric Assessment Improves Prediction of Surgical Outcomes in Older Adults Undergoing Pancreaticoduodenectomy: A Prospective Cohort Study , 2014, Annals of surgery.

[34]  M. RevenigLouis,et al.  A Prospective Study Examining the Association Between Preoperative Frailty and Postoperative Complications in Patients Undergoing Minimally Invasive Surgery , 2014 .

[35]  J. Stoot,et al.  Value of Geriatric Frailty and Nutritional Status Assessment in Predicting Postoperative Mortality in Gastric Cancer Surgery , 2014, Journal of Gastrointestinal Surgery.

[36]  I. Rubinfeld,et al.  Assessment of morbidity and mortality after esophagectomy using a modified frailty index. , 2013, The Annals of thoracic surgery.

[37]  K. Ogan,et al.  Too frail for surgery? Initial results of a large multidisciplinary prospective study examining preoperative variables predictive of poor surgical outcomes. , 2013, Journal of the American College of Surgeons.

[38]  Marc Moss,et al.  Simple frailty score predicts postoperative complications across surgical specialties. , 2013, American journal of surgery.

[39]  I. Rubinfeld,et al.  Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database. , 2013, The Journal of surgical research.

[40]  L. Feldman,et al.  Impact of a trimodal prehabilitation program on functional recovery after colorectal cancer surgery: a pilot study , 2013, Surgical Endoscopy.

[41]  Maureen A. Smith,et al.  Predictors of Short-Term Postoperative Survival After Elective Colectomy in Colon Cancer Patients ≥80 Years of Age , 2013, Annals of Surgical Oncology.

[42]  M. Ruiz,et al.  Frailty Syndrome in Geriatric Medicine , 2012, The American journal of the medical sciences.

[43]  V. Caso,et al.  Perioperative Stroke Risk in Nonvascular Surgery , 2012, Cerebrovascular Diseases.

[44]  Terence Tang,et al.  Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. , 2012, American journal of surgery.

[45]  A. Jazaeri,et al.  Frailty: an outcome predictor for elderly gynecologic oncology patients. , 2012, Gynecologic oncology.

[46]  I. Rubinfeld,et al.  Predictors of critical care-related complications in colectomy patients using the National Surgical Quality Improvement Program: Exploring frailty and aggressive laparoscopic approaches , 2012, The journal of trauma and acute care surgery.

[47]  M. Ciarleglio,et al.  Postoperative Complications After Gynecologic Surgery , 2011, Obstetrics and gynecology.

[48]  K. Tepetes,et al.  Colorectal cancer surgery in the elderly: limitations and drawbacks , 2011, Techniques in Coloproctology.

[49]  R. Audisio,et al.  Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. , 2010, Critical reviews in oncology/hematology.

[50]  M. Makary,et al.  Frailty as a predictor of surgical outcomes in older patients. , 2010, Journal of the American College of Surgeons.

[51]  Justin B Dimick,et al.  Variation in hospital mortality associated with inpatient surgery. , 2009, The New England journal of medicine.

[52]  V. Velanovich,et al.  Preoperative Frailty and Quality of Life as Predictors of Postoperative Complications , 2009, Annals of surgery.

[53]  V. Ranieri,et al.  Respiratory complications after major surgery , 2009, Current opinion in critical care.

[54]  Sam-Kwon Jung,et al.  Internet marketing strategy of a wholesale tour agency in Korea: Case of Hana Tour , 2009, J. Serv. Sci. Res..

[55]  Thomas L. Saaty,et al.  DECISION MAKING WITH THE ANALYTIC HIERARCHY PROCESS , 2008 .

[56]  Patrick S. Romano,et al.  Failure-to-Rescue: Comparing Definitions to Measure Quality of Care , 2007, Medical care.

[57]  T. Strandberg,et al.  Frailty in elderly people , 2007, The Lancet.

[58]  S. Studenski,et al.  Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults , 2006, Journal of the American Geriatrics Society.

[59]  N. Demartines,et al.  Classification of Surgical Complications: A New Proposal With Evaluation in a Cohort of 6336 Patients and Results of a Survey , 2004, Annals of Surgery.

[60]  W. Henderson,et al.  The National Surgical Quality Improvement Program in Non-Veterans Administration Hospitals: Initial Demonstration of Feasibility , 2002, Annals of surgery.

[61]  J. Sterne,et al.  Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. , 2001, Journal of clinical epidemiology.

[62]  F. Grover,et al.  The Department of Veterans Affairs' NSQIP: the first national, validated, outcome-based, risk-adjusted, and peer-controlled program for the measurement and enhancement of the quality of surgical care. National VA Surgical Quality Improvement Program. , 1998, Annals of surgery.

[63]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[64]  V. Dicarlo.  Health care resources consumed to treat postoperative infections : cost saving by perioperative immunonutrition , 2017 .

[65]  Geerard L Beets,et al.  Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery. , 2015, Annals of surgery.

[66]  P. Thaker,et al.  Pre-operative Assessment of Muscle Mass to Predict Surgical Complications and Prognosis in Patients With Endometrial Cancer , 2014, Annals of Surgical Oncology.

[67]  K. Ogan,et al.  A prospective study examining the association between preoperative frailty and postoperative complications in patients undergoing minimally invasive surgery. , 2014, Journal of endourology.