论文信息 - A Highly Diastereoselective Tertiary Amine‐Catalyzed Cascade Michael—Michael—Henry Reaction Between Nitromethane, Activated Alkenes and α,β‐Unsaturated Carbonyl Compounds.

A Highly Diastereoselective Tertiary Amine‐Catalyzed Cascade Michael—Michael—Henry Reaction Between Nitromethane, Activated Alkenes and α,β‐Unsaturated Carbonyl Compounds.

A new tertiary amine-catalyzed cascade Michael-Michael-Henry reaction between nitromethane, a doubly activated alkene and an α,β-unsaturated carbonyl compound is described, which provides a convenient and efficient synthesis for densely functionalized cyclohexanes and some bicyclic compounds in moderate to excellent yields with high diastereoselectivity.

B. Zhang | Zhengjie He | Zhihong Wang | Lingchao Cai | Hai-bin Song

[1] Bo Zhang,et al. A Highly Diastereoselective Tertiary Amine-Catalyzed Cascade Michael-Michael-Henry Reaction between Nitromethane, Activated Alkenes and α,β-Unsaturated Carbonyl Compounds , 2010 .