Depressive Mood Symptoms and Fatigue After Exercise Withdrawal: The Potential Role of Decreased Fitness

Objective: Depressive symptomatology is more prevalent among sedentary than physically active individuals. The present prospective study examines whether withdrawal of regular aerobic activity provokes depressive mood symptoms and fatigue, and to what extent reductions in fitness levels contribute to the development of these symptoms. Methods: Forty participants (mean age of 31.3 ± 7.5 years, 55% women) who exercised regularly (≥30 minutes aerobic exercise ≥3 times/week) were randomized to aerobic exercise withdrawal (n = 20) or to continue regular exercise (n = 20) for 2 weeks. Protocol adherence was documented using ambulatory actigraphy. Negative mood was measured with the Profile of Mood States (POMS), depressive symptoms with the Beck Depression Inventory–II (somatic and cognitive–affective components), and fatigue with the Multidimensional Fatigue Inventory (MFI). Fitness levels were documented by cycle ergometry testing. Results: Fatigue and somatic depressive symptoms emerged after 1 week of exercise withdrawal (p = .05) and subsequently predicted the development of cognitive–affective depressive symptoms at 2 weeks (&bgr; = 0.62; p = .046). Exercise withdrawal also resulted in increased negative mood (POMS; p ≤ .01), and this increase was correlated with decreases in fitness level (r = −0.36, p = .03). Decreased fitness was related to increased POMS fatigue (p = .003) when statistically adjusting for baseline fitness levels and group condition. Conclusion: Depressed mood and fatigue are commonly observed in individuals deprived of usual exercise activities, and the increase in fatigue may be partially mediated by reduced fitness levels. These findings may explain mood changes in response to short-term exercise withdrawal such as injuries and recovery from medical procedures that do not require full bedrest. BDI-II = Beck Depression Inventory–II; BMI = body mass index; HR = heart rate; MET = metabolic equivalent of task; MFI = Multidimensional Fatigue Inventory; POMS = Profile of Mood States; TMD = total mood disturbance; VO2max = maximum volume of oxygen that can be used per minute; index of maximal aerobic power.

[1]  J. Després,et al.  American College of Sports Medicine Position Stand. The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults. , 1998, Medicine and science in sports and exercise.

[2]  Pullen Library Physiological and Psychological Effects of Short-term Exercise Addiction on Habitual Runners , 1982 .

[3]  J. Robbins,et al.  Experiencing Exercise Withdrawal: Possible Consequences of Therapeutic and Mastery Running , 1985 .

[4]  J. Conboy The Effects of Exercise Withdrawal on Mood States in Runners , 1994 .

[5]  R. Yeung,et al.  The acute effects of exercise on mood state. , 1996, Journal of psychosomatic research.

[6]  S A Jebb,et al.  Contribution of a sedentary lifestyle and inactivity to the etiology of overweight and obesity: current evidence and research issues. , 1999, Medicine and science in sports and exercise.

[7]  C S Chan,et al.  Psychological Effects of Running Loss on Consistent Runners , 1988, Perceptual and motor skills.

[8]  E. Smets,et al.  The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. , 1995, Journal of psychosomatic research.

[9]  D. Swain,et al.  Prediction of VO2peak from submaximal cycle ergometry using 50 versus 80 rpm. , 1997, Medicine and science in sports and exercise.

[10]  A. Szabó The impact of exercise deprivation on well-being of habitual exercises. , 1995, Australian journal of science and medicine in sport.

[11]  L. Gauvin,et al.  Application of the Experience Sampling Method to the Study of the Effects of Exercise Withdrawal on Weil-Being , 1992 .

[12]  Bryan Jennett,et al.  AIR TRAVEL AND THROMBOTIC EPISODES: THE ECONOMY CLASS SYNDROME , 1988, The Lancet.

[13]  W. Morgan,et al.  Psychological consequences of exercise deprivation in habitual exercisers. , 1996, Medicine and science in sports and exercise.

[14]  J. Mitchell,et al.  The physiological meaning of the maximal oxygen intake test. , 1958, The Journal of clinical investigation.

[15]  J. Albers,et al.  Response of HDL cholesterol, apoprotein A-I, and LCAT to exercise withdrawal. , 1985, Atherosclerosis.

[16]  J. Mitchell,et al.  Response to exercise after bed rest and after training. , 1968, Circulation.

[17]  S. Weyerer Physical Inactivity and Depression in the Community , 1992, International journal of sports medicine.

[18]  P. Salmon,et al.  Effects of temporary withdrawal from regular running. , 1990, Journal of psychosomatic research.

[19]  M. Trivedi,et al.  Physical activity dose-response effects on outcomes of depression and anxiety. , 2001, Medicine and science in sports and exercise.

[20]  J. Greenleaf,et al.  Effects of 3-day bed rest on physiological responses to graded exercise in athletes and sedentary men. , 2001, Journal of applied physiology.

[21]  Daniel J Clauw,et al.  The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals. , 2004, Journal of psychosomatic research.

[22]  H. Kohl,et al.  A mail survey of physical activity habits as related to measured physical fitness. , 1988, American journal of epidemiology.

[23]  M. Puyau,et al.  Validation and calibration of physical activity monitors in children. , 2002, Obesity research.

[24]  H. Helm,et al.  Factor Structure of The Beck Depression Inventory in a University Sample , 2003, Psychological reports.

[25]  B E Ainsworth,et al.  Compendium of physical activities: an update of activity codes and MET intensities. , 2000, Medicine and science in sports and exercise.

[26]  R. Emmerson,et al.  Cardio-respiratory fitness of young and older active and sedentary men. , 1988, British journal of sports medicine.

[27]  M. Lorr,et al.  Profile of mood states , 1971 .

[28]  A L Dannenberg,et al.  Physical activity and depressive symptoms: the NHANES I Epidemiologic Follow-up Study. , 1988, American journal of epidemiology.

[29]  L. Wallentin,et al.  Prevention of serious cardiac events by low-dose aspirin in patients with silent myocardial ischaemia , 1992, The Lancet.

[30]  Robert B. Wallace,et al.  Walking and Depression in a Cohort of Older Adults: The Iowa 65+ Rural Health Study , 1996 .

[31]  B. Saltin,et al.  Physiological Analysis of Middle‐Aged and Old Former Athletes: Comparison with Still Active Athletes of the Same Ages , 1968, Circulation.

[32]  Carol Ewing Garber,et al.  ACSM Position Stand: The Recommended Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory and Muscular Fitness, and Flexibility in Healthy Adults , 1998 .

[33]  E. Shvartz,et al.  Aerobic fitness norms for males and females aged 6 to 75 years: a review. , 1990, Aviation, space, and environmental medicine.

[34]  David A. Williams,et al.  Ambulatory monitoring of physical activity and symptoms in fibromyalgia and chronic fatigue syndrome. , 2005, Arthritis and rheumatism.

[35]  David S. Krantz,et al.  Automated physical activity monitoring: validation and comparison with physiological and self-report measures. , 1993, Psychophysiology.

[36]  V. Convertino Cardiovascular consequences of bed rest: effect on maximal oxygen uptake. , 1997, Medicine and science in sports and exercise.

[37]  John E. Perez,et al.  Factor structure of the Beck Depression Inventory-Second Edition (BDI-II) in a student sample. , 2000, Journal of clinical psychology.