Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
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Christina Cherian | Jianmei Wu | L. Matherly | Z. Hou | L. Polin | A. Gangjee | Yijun Deng | S. Desmoulin | K. White | J. Kushner | Lei Wang