Electrical Sources of P300 Event-Related Brain Potentials Revealed by Low Resolution Electromagnetic Tomography

The P300 event-related potential (ERP) is considered to be closely related to cognitive processes. Previous reports regarding major generators contributing to the scalp-recorded P300 suggested widely distributed multiple sources. Based on ERPs recorded in 172 normal healthy subjects aged between 20 and 88 years in an auditory oddball paradigm, electrical activity in the brain corresponding to N1 and P300 components was localized by means of low resolution electromagnetic tomography (LORETA). The N1 LORETA generators, located in both auditory cortices, did not change over age. On the other hand, the P300 LORETA generators, located predominantly in the frontal neocortex and less pronounced in the posterior parietal cortex, decreased over age both in frontal and parietal source strength.

[1]  H. Semlitsch,et al.  Multichannel auditory event-related brain potentials: effects of normal aging on the scalp distribution of N1, P2, N2 and P300 latencies and amplitudes. , 1996, Electroencephalography and clinical neurophysiology.

[2]  M S Albert,et al.  Differences in abstraction ability with age. , 1990, Psychology and aging.

[3]  H. Semlitsch,et al.  Topographic mapping of long latency “cognitive” event-related potentials (P 300): a double-blind, placebo-controlled study with amantadine in mild dementia , 1992, Journal of neural transmission. Parkinson's disease and dementia section.

[4]  C C Wood,et al.  Intracranial recordings of endogenous ERPs in humans. , 1985, Electroencephalography and clinical neurophysiology. Supplement.

[5]  R. Johnson.  A triarchic model of P300 amplitude. , 1986, Psychophysiology.

[6]  J. Polich,et al.  Cognitive and biological determinants of P300: an integrative review , 1995, Biological Psychology.

[7]  D. Ruchkin,et al.  Multiple sources of P3b associated with different types of information. , 1990, Psychophysiology.

[8]  H. Semlitsch,et al.  EEG brain mapping and psychometry in age-associated memory impairment after acute and 2-week infusions with the hemoderivative Actovegin: double-blind, placebo-controlled trials. , 1990, Neuropsychobiology.

[9]  H. Semlitsch,et al.  Psychophysiological research in psychiatry and neuropsychopharmacology. II. The investigation of antihypoxidotic/nootropic drugs (tenilsetam and co-dergocrine-mesylate) in elderlies with the Viennese Psychophysiological Test-System (VPTS). , 1989, Methods and findings in experimental and clinical pharmacology.

[10]  H. Semlitsch,et al.  Cognitive Psychophysiology in Nootropic Drug Research: Effects of Ginkgo biloba on Event-related Potentials (P300) in Age-associated Memory Impairment , 1995, Pharmacopsychiatry.

[11]  K Abt,et al.  Statistical Aspects of Neurophysiologic Topography , 1990, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[12]  R. Verleger,et al.  Event-related EEG potentials in mild dementia of the Alzheimer type. , 1992, Electroencephalography and clinical neurophysiology.

[13]  D. Lehmann,et al.  Principles of spatial analysis , 1987 .

[14]  F. Perrin,et al.  Tonotopic organization of the human auditory cortex: N100 topography and multiple dipole model analysis. , 1995, Electroencephalography and clinical neurophysiology.

[15]  Bernd Saletu,et al.  Artifact processing in topographic mapping of electroencephalographie activity in neuropsychopharmacology , 1992, Psychiatry Research: Neuroimaging.

[16]  H. Semlitsch,et al.  Topographical and source analysis of the P300 event-related brain potential in normal aging and in age-associated memory impairment before and after Ginkgo biloba therapy , 1996, NeuroImage.

[17]  H. Semlitsch,et al.  Testing Drugs for Impaired Brain Function in Old Age: On the Effects of a Single Dose of Bifemelane using Topographic Mapping of EEG and Event‐Related Potentials (P300) and Psychometric Measurements in Healthy Elderly Subjects , 1996 .

[18]  C. Frith,et al.  A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory , 1996, Neuropsychologia.

[19]  A Pfefferbaum,et al.  Event-related potentials and eyeblink responses in automatic and controlled processing: effects of age. , 1991, Electroencephalography and clinical neurophysiology.

[20]  S. Baumann,et al.  Localization of the P3 sources using magnetoencephalography and magnetic resonance imaging. , 1991, Electroencephalography and clinical neurophysiology.

[21]  J. Growdon,et al.  Iofetamine I 123 single photon emission computed tomography is accurate in the diagnosis of Alzheimer's disease. , 1990, Archives of internal medicine.

[22]  K. Lehnertz,et al.  Tonotopic organization of the human auditory cortex revealed by transient auditory evoked magnetic fields. , 1988, Electroencephalography and clinical neurophysiology.

[23]  M. Shenton,et al.  Electrical source analysis of auditory ERPs in medial temporal lobe amnestic syndrome. , 1993, Electroencephalography and clinical neurophysiology.

[24]  Antoine Rémond,et al.  Methods of Analysis of Brain Electrical and Magnetic Signals , 1987 .

[25]  D Friedman,et al.  Age-related changes in scalp topography to novel and target stimuli. , 1993, Psychophysiology.

[26]  H. Semlitsch,et al.  Topographic mapping of cognitive event-related potentials in a double-blind, placebo-controlled study with the hemoderivative Actovegin in age-associated memory impairment. , 1990, Neuropsychobiology.

[27]  G. Wright.  Objective assessment in dementia: automated psychometric tests and the P3. , 1990, Neuroepidemiology.

[28]  M. Haider.  Handbook of electroencephalography and clinical neurophysiology , 1978 .

[29]  G. Simpson,et al.  Brain electrical activity in aging: Different age-related intracranial configurations revealed by source localization , 1996, NeuroImage.

[30]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. I. Superior temporal plane and parietal lobe. , 1995, Electroencephalography and clinical neurophysiology.

[31]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. II. Medial, lateral and posterior temporal lobe. , 1995, Electroencephalography and clinical neurophysiology.

[32]  F. Rösler,et al.  Endogenous ERP components and cognitive constructs. A review. , 1986, Electroencephalography and clinical neurophysiology. Supplement.

[33]  I. Kiss,et al.  A parieto-occipital generator for P300: evidence from human intracranial recordings. , 1989, The International journal of neuroscience.

[34]  D. Lehmann,et al.  Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[35]  T W Picton,et al.  The P300 Wave of the Human Event‐Related Potential , 1992, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[36]  B. Saletu.  EEG Brain Mapping in Diagnostic and Therapeutic Assessment of Dementia , 1991, Alzheimer disease and associated disorders.

[37]  D. Lehmann,et al.  Reference-free identification of components of checkerboard-evoked multichannel potential fields. , 1980, Electroencephalography and clinical neurophysiology.

[38]  J. Polich,et al.  Meta-analysis of P300 normative aging studies. , 1996, Psychophysiology.

[39]  J. Ford,et al.  Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. , 1984, Electroencephalography and clinical neurophysiology.

[40]  K Patterson,et al.  Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[41]  J. Polich,et al.  P300 in young and elderly subjects: auditory frequency and intensity effects. , 1993, Electroencephalography and clinical neurophysiology.

[42]  William E. Semple,et al.  Functional localization of sustained attention: Comparison to sensory stimulation in the absence of instruction , 1988 .

[43]  J. Polich.  On the clinical application of P300 , 1992, Biological Psychiatry.

[44]  M. Scherg,et al.  A Source Analysis of the Late Human Auditory Evoked Potentials , 1989, Journal of Cognitive Neuroscience.

[45]  S A Hillyard,et al.  Effects of aging on event-related brain potentials and reaction times in an auditory oddball task. , 2007, Psychophysiology.

[46]  R. Hari,et al.  Recording and interpretation of cerebral magnetic fields. , 1989, Science.

[47]  J. C. Gore,et al.  Functional magnetic resonance imaging in a visual oddball task , 1996, NeuroImage.

[48]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex. , 1995, Electroencephalography and clinical neurophysiology.

[49]  J. Polich,et al.  P300 in the evaluation of aging and dementia. , 1991, Electroencephalography and clinical neurophysiology. Supplement.

[50]  R. Johnson,et al.  On the neural generators of the P300 component of the event-related potential. , 2007, Psychophysiology.

[51]  R. L. Rogers,et al.  Cerebral blood flow changes in benign aging and cerebrovascular disease , 1984, Neurology.

[52]  A. Papanicolaou,et al.  Electric source localization of the auditory P300 agrees with magnetic source localization. , 1995, Electroencephalography and clinical neurophysiology.

[53]  A Pfefferbaum,et al.  Clinical application of the P3 component of event-related potentials. I. Normal aging. , 1984, Electroencephalography and clinical neurophysiology.

[54]  E. Halgren,et al.  The intracranial topography of the P3 event-related potential elicited during auditory oddball. , 1990, Electroencephalography and clinical neurophysiology.

[55]  S. Ferris,et al.  Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group , 1986 .