Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution

[1]  K. Nadeau,et al.  Fructose and sugar: A major mediator of non-alcoholic fatty liver disease. , 2018, Journal of hepatology.

[2]  C. Stehouwer,et al.  Adipose tissue macrophages induce hepatic neutrophil recruitment and macrophage accumulation in mice , 2017, Gut.

[3]  Maria Ryaboshapkina,et al.  Human hepatic gene expression signature of non-alcoholic fatty liver disease progression, a meta-analysis , 2017, Scientific Reports.

[4]  J. Gugenheim,et al.  CD44 is a key player in non-alcoholic steatohepatitis. , 2017, Journal of hepatology.

[5]  J. Eeckhoute,et al.  Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin. , 2017, JCI insight.

[6]  L. Miles,et al.  Hepatic natural killer T‐cell and CD8+ T‐cell signatures in mice with nonalcoholic steatohepatitis , 2017, Hepatology communications.

[7]  W. Chapman,et al.  Type I interferon responses drive intrahepatic T cells to promote metabolic syndrome , 2017, Science Immunology.

[8]  R. Förster,et al.  Dendritic cell migration in health and disease , 2016, Nature Reviews Immunology.

[9]  Michael Roden,et al.  NAFLD and diabetes mellitus , 2017, Nature Reviews Gastroenterology &Hepatology.

[10]  H. Tilg,et al.  Adipose type I interferon signalling protects against metabolic dysfunction , 2016, Gut.

[11]  K. Murphy,et al.  Functions of Murine Dendritic Cells. , 2016, Immunity.

[12]  P. Bedossa,et al.  A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer , 2016, Journal of hepatology.

[13]  B. Staels,et al.  Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease. , 2016, Annual review of physiology.

[14]  G. Ioannou.  The Role of Cholesterol in the Pathogenesis of NASH , 2016, Trends in Endocrinology & Metabolism.

[15]  H. Hermanns,et al.  Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver , 2016, The Journal of Immunology.

[16]  P. Schauer,et al.  Effect of Roux-en-Y gastric bypass and sleeve gastrectomy on nonalcoholic fatty liver disease: a comparative study. , 2016, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

[17]  D. Kleiner,et al.  Liver histology and clinical trials for nonalcoholic steatohepatitis-perspectives from 2 pathologists. , 2015, Gastroenterology.

[18]  F. Nevens,et al.  Association of Adipose Tissue Inflammation With Histologic Severity of Nonalcoholic Fatty Liver Disease. , 2015, Gastroenterology.

[19]  S. Friedman,et al.  Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. , 2015, Gastroenterology.

[20]  F. Pattou,et al.  Bariatric Surgery Reduces Features of Nonalcoholic Steatohepatitis in Morbidly Obese Patients. , 2015, Gastroenterology.

[21]  E. van Marck,et al.  PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis. , 2015, Journal of hepatology.

[22]  D. Schrijvers,et al.  CD4+RORγt++ and Tregs in a Mouse Model of Diet-Induced Nonalcoholic Steatohepatitis , 2015, Mediators of inflammation.

[23]  N. Bertho,et al.  Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions , 2015, Front. Immunol..

[24]  G. Gores,et al.  Ballooned hepatocytes, undead cells, sonic hedgehog, and Vitamin E: Therapeutic implications for nonalcoholic steatohepatitis , 2015, Hepatology.

[25]  Jun Yu,et al.  CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis. , 2014, Journal of hepatology.

[26]  B. Staels,et al.  The transrepressive activity of peroxisome proliferator‐activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice , 2014, Hepatology.

[27]  H. Moch,et al.  Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. , 2014, Cancer cell.

[28]  E. Şenateş,et al.  HLA DQB1 alleles are related with nonalcoholic fatty liver disease , 2014, Molecular Biology Reports.

[29]  Nunzio Bottini,et al.  Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. , 2014, Annual review of immunology.

[30]  E. Albano,et al.  Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH , 2014, Hepatology.

[31]  S. Murphy,et al.  Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease , 2014, Hepatology.

[32]  J. Geoghegan,et al.  CD141⁺ myeloid dendritic cells are enriched in healthy human liver. , 2014, Journal of hepatology.

[33]  M. Taskinen,et al.  A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population , 2013, Obesity.

[34]  Soumitra S Ghosh,et al.  Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment. , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[35]  L. Vonghia,et al.  Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis , 2013, International journal of molecular sciences.

[36]  A. Rehman,et al.  Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice , 2013, Hepatology.

[37]  S. Curbishley,et al.  Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics , 2013, Hepatology.

[38]  Joan Tordjman,et al.  Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients , 2012, Hepatology.

[39]  N. Van Rooijen,et al.  Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[40]  B. Neuschwander‐Tetri,et al.  Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings , 2011, Hepatology.

[41]  G. Karaca,et al.  Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease , 2010, Hepatology.

[42]  Elizabeth M. Brunt,et al.  Pathology of nonalcoholic fatty liver disease , 2010, Nature Reviews Gastroenterology &Hepatology.

[43]  T. Kadowaki,et al.  CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity , 2009, Nature Medicine.

[44]  Steve Horvath,et al.  WGCNA: an R package for weighted correlation network analysis , 2008, BMC Bioinformatics.

[45]  E. Chi,et al.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. , 2008, Immunity.

[46]  M. Yeh,et al.  Pathology of nonalcoholic fatty liver disease. , 2007, American journal of clinical pathology.

[47]  John D. Storey,et al.  Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis , 2007, PLoS genetics.

[48]  Peter Bühlmann,et al.  Analyzing gene expression data in terms of gene sets: methodological issues , 2007, Bioinform..

[49]  Michael Karin,et al.  IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy , 2005 .

[50]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[51]  Gordon K. Smyth,et al.  Use of within-array replicate spots for assessing differential expression in microarray experiments , 2005, Bioinform..

[52]  Michael Karin,et al.  IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. , 2005, The Journal of clinical investigation.

[53]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[54]  Rafael A Irizarry,et al.  Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.

[55]  A. Scheen,et al.  Non-alcoholic steatohepatitis: association with obesity and insulin resistance, and influence of weight loss. , 2000, Diabetes & metabolism.