The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

[1]  G. Musso,et al.  Sterol Regulatory Element-Binding Factor 2 (SREBF-2) Predicts 7-Year NAFLD Incidence and Severity of Liver Disease and Lipoprotein and Glucose Dysmetabolism , 2013, Diabetes.

[2]  G. Musso,et al.  Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. , 2013, Progress in lipid research.

[3]  G. Musso,et al.  Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism , 2012, Hepatology.

[4]  B. Neuschwander‐Tetri,et al.  Ezetimibe: Its Novel Effects on the Prevention and the Treatment of Cholesterol Gallstones and Nonalcoholic Fatty Liver Disease , 2011, Journal of lipids.

[5]  T. Hibi,et al.  A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells. , 2012, Gastroenterology.

[6]  G. Musso,et al.  Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials , 2012, Diabetologia.

[7]  K. Moore,et al.  MicroRNA modulation of cholesterol homeostasis. , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[8]  H. Aburatani,et al.  Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet. , 2011, Metabolism: clinical and experimental.

[9]  L. Jia,et al.  Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis[S] , 2010, Journal of Lipid Research.

[10]  Takeshi Kimura,et al.  MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo , 2010, Proceedings of the National Academy of Sciences.

[11]  G. Musso,et al.  Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis. , 2010, The Journal of nutritional biochemistry.

[12]  I. Gérin,et al.  Expression of miR-33 from an SREBP2 Intron Inhibits Cholesterol Export and Fatty Acid Oxidation* , 2010, The Journal of Biological Chemistry.

[13]  Hirokazu Takahashi,et al.  Efficacy of ezetimibe for the treatment of non‐alcoholic steatohepatitis: An open‐label, pilot study , 2010, Hepatology research : the official journal of the Japan Society of Hepatology.

[14]  H. Goto,et al.  Effects of 1‐O‐hexyl‐2,3,5‐trimethylhydroquinone on carbon tetrachloride‐induced hepatic cirrhosis in rats , 2010, Hepatology research : the official journal of the Japan Society of Hepatology.

[15]  T. Okanoue,et al.  Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease , 2010, Journal of Gastroenterology.

[16]  S. Kaneko,et al.  Histological Course of Nonalcoholic Fatty Liver Disease in Japanese Patients , 2009, Diabetes Care.

[17]  Shuichi Kaneko,et al.  Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria , 2009, Journal of Biological Chemistry.

[18]  F. Sladek,et al.  Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia via SREBPs. , 2009, Molecular endocrinology.

[19]  T. Osborne,et al.  Selective Binding of Sterol Regulatory Element-binding Protein Isoforms and Co-regulatory Proteins to Promoters for Lipid Metabolic Genes in Liver* , 2008, Journal of Biological Chemistry.

[20]  M. Haraguchi,et al.  Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome , 2007, FEBS letters.

[21]  M. Honda,et al.  Lipid‐induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet , 2007, Hepatology.

[22]  C. McClain,et al.  Palmitic acid induces production of proinflammatory cytokine interleukin‐8 from hepatocytes , 2007, Hepatology.

[23]  Amalia Gastaldelli,et al.  Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects. , 2007, Gastroenterology.

[24]  M. Willingham,et al.  Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. , 2007, The Journal of clinical investigation.

[25]  M. Pagliassotti,et al.  Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. , 2007, Endocrinology.

[26]  M. Matsuda,et al.  Muscle and Liver Insulin Resistance Indexes Derived From the Oral Glucose Tolerance Test , 2007, Diabetes Care.

[27]  S. Kaneko,et al.  Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease , 2007, Journal of Gastroenterology.

[28]  A. Colell,et al.  Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. , 2006, Cell metabolism.

[29]  G. Gores,et al.  Free Fatty Acids Induce JNK-dependent Hepatocyte Lipoapoptosis* , 2006, Journal of Biological Chemistry.

[30]  B. Hawes,et al.  The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[31]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[32]  Luquan Wang,et al.  Materials and Methods Figs. S1 to S4 Tables S1 and S2 References Niemann-pick C1 like 1 Protein Is Critical for Intestinal Cholesterol Absorption , 2022 .

[33]  J. Hoofnagle,et al.  A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis , 2004, Hepatology.

[34]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[35]  F. Gonzalez,et al.  The Coactivator PGC-1 Is Involved in the Regulation of the Liver Carnitine Palmitoyltransferase I Gene Expression by cAMP in Combination with HNF4α and cAMP-response Element-binding Protein (CREB)* , 2002, The Journal of Biological Chemistry.

[36]  M. Brown,et al.  Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D A Follmann,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans , 2022 .

[38]  B. Neuschwander‐Tetri,et al.  Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions , 1999, American Journal of Gastroenterology.

[39]  T. Takamura,et al.  Acute hyperinsulinemia reduces plasma concentrations of homocysteine in healthy men. , 1999, Diabetes care.

[40]  M. Matsuda,et al.  Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.

[41]  R. DeFronzo,et al.  Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.