A note on the influence of diet in West Africa on urinary pH and excretion of amphetamine in man

The urinary excretion of amphetamine was examined after the oral administration of (+)‐amphetamine sulphate to two groups of subjects whose urinary pH fluctuated about mean acidic or alkaline values due to their different diets. The group with a balanced protein diet giving acidic urine, excreted much more drug unchanged than the group with a low protein diet giving alkaline urine. A small increase in protein intake in the group with alkaline urine made their urine pH acidic in a few days and increased their excretion of amphetamine to the same level as the group with acid urine.