Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
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Laura Sepp-Lorenzino | S. Stirdivant | M. Ikuta | L. Sepp-Lorenzino | R. Lobell | C. Buser | K. Rickert | V. Dudkin | M. Fraley | K. Arrington | G. Hartman | George D Hartman | Keith Rickert | Constantine Kreatsoulas | Carolyn A Buser | Robert B Lobell | Eileen S Walsh | E. Walsh | Cheng Wang | Mark E Fraley | Constantine Kreatsoulas | Kelly Hamilton | Mari Ikuta | Kenneth L Arrington | Steven M Stirdivant | Vadim Y Dudkin | Cheng Wang | Yowei Yan | Robert A Drakas | K. Hamilton | R. Drakas | Yongyan Yan
[1] Ian Collins,et al. Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases. , 2010, Bioorganic & medicinal chemistry letters.
[2] Andrew Potter,et al. Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening. , 2006, Bioorganic & medicinal chemistry.
[3] Nicolas Foloppe,et al. Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification. , 2005, Bioorganic & medicinal chemistry.
[4] J. Bartek,et al. p53‐dependent G1 arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors , 2010, Cell proliferation.
[5] A. Sancar,et al. Reconstitution of a human ATR-mediated checkpoint response to damaged DNA , 2007, Proceedings of the National Academy of Sciences.
[6] F. Bunz,et al. Checkpoint bypass and cell viability , 2010, Cell cycle.
[7] W. L. Jorgensen,et al. Comparison of simple potential functions for simulating liquid water , 1983 .
[8] D. Conrad,et al. Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways , 2003, Cancer biology & therapy.
[9] Cynthia Winter,et al. RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma , 2011, Proceedings of the National Academy of Sciences.
[10] W. F. Hoffman,et al. Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. , 2002, Bioorganic & medicinal chemistry letters.
[11] Yun Dai,et al. New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network , 2010, Clinical Cancer Research.
[12] M. Prudhomme. Novel checkpoint 1 inhibitors. , 2006, Recent patents on anti-cancer drug discovery.
[13] Jiri Bartek,et al. Chk1 and Chk2 kinases in checkpoint control and cancer. , 2003, Cancer cell.
[14] Michael Reilly,et al. Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. , 2006, Bioorganic & medicinal chemistry letters.
[15] Synthesis and evaluation of 5-substituted 9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as check point 1 kinase inhibitors. , 2010, Bioorganic & medicinal chemistry.
[16] Michael B Yaffe,et al. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. , 2007, Cancer cell.
[17] T. Helleday,et al. Chk1 promotes replication fork progression by controlling replication initiation , 2010, Proceedings of the National Academy of Sciences.
[18] Stephen Green,et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies , 2008, Molecular Cancer Therapeutics.
[19] Lawrence C Kuo,et al. 3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6. , 2006, Bioorganic & medicinal chemistry letters.
[20] S. Fesik,et al. Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint. , 2003, Molecular cancer therapeutics.
[21] D. Heimbrook,et al. Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel. , 2004, Journal of medicinal chemistry.
[22] M. Broggini,et al. Chk1, but not Chk2 , is Involved in the Cellular Response to DNA Damaging Agents: Differential Activity in Cells Expressing, or not, p53 , 2004, Cell cycle.
[23] Georgia B McGaughey,et al. The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase. , 2004, Bioorganic & medicinal chemistry letters.
[24] Laura Sepp-Lorenzino,et al. Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. , 2007, Bioorganic & medicinal chemistry letters.