Effect of Heart Rate on T Wave Alternans

Heart Rate and T Wave Alternans. Introduction: T wave alternans (TWA) is a promising technique for detecting arrhythmia vulnerability. Previous studies in animals demonstrated that the magnitude of TWA is dependent on heart rate. However, the effects of heart rate on TWA in humans and the clinical relevance of this effect remain controversial.

[1]  R J Cohen,et al.  T Wave Alternans During Exercise and Atrial Pacing in Humans , 1997, Journal of cardiovascular electrophysiology.

[2]  D. Rosenbaum,et al.  Modulation of ventricular repolarization by a premature stimulus. Role of epicardial dispersion of repolarization kinetics demonstrated by optical mapping of the intact guinea pig heart. , 1996, Circulation research.

[3]  M R Franz,et al.  Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contraction. , 1988, Circulation.

[4]  R. Verrier,et al.  Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. , 1991, Science.

[5]  Bigger Jt,et al.  Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery , 1997 .

[6]  D. T. Kaplan,et al.  Repolarization Inhomogeneities in Ventricular Myocardium Change Dynamically With Abrupt Cycle Length Shortening , 1991, Circulation.

[7]  J. Ruskin,et al.  Electrical alternans and vulnerability to ventricular arrhythmias. , 1994, The New England journal of medicine.

[8]  A. Camm,et al.  Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT , 1997, The Lancet.

[9]  R J Cohen,et al.  Electrical alternans and cardiac electrical instability. , 1988, Circulation.

[10]  R. Peters,et al.  Comparison of class Ia/Ib versus class III antiarrhythmic drugs for the suppression of inducible sustained ventricular tachycardia associated with coronary artery disease. , 1997, The American journal of cardiology.

[11]  S Yasui,et al.  Significance of discordant ST alternans in ventricular fibrillation. , 1990, Circulation.

[12]  R J Cohen,et al.  Predicting Sudden Cardiac Death From T Wave Alternans of the Surface Electrocardiogram: , 1996, Journal of cardiovascular electrophysiology.

[13]  A. Moss,et al.  Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators. , 1996, The New England journal of medicine.

[14]  A. Waldo,et al.  Insights into the Electrophysiology Study Versus Electrocardiographic Monitoring Trial: its programmed stimulation protocol may introduce bias when assessing long-term antiarrhythmic drug therapy. , 1995, Journal of the American College of Cardiology.

[15]  N Engl,et al.  Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. , 1997, Circulation.

[16]  S. Gottlieb Dead is dead—artificial definitions are no substitute , 1997, The Lancet.

[17]  F. Suliman,et al.  Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. , 1998, The New England journal of medicine.

[18]  K. Byth,et al.  What Is the Best Predictor of Spontaneous Ventricular Tachycardia and Sudden Death After Myocardial Infarction? , 1991, Circulation.

[19]  D. Adam,et al.  Fluctuations in T-wave morphology and susceptibility to ventricular fibrillation. , 1984, Journal of electrocardiology.

[20]  A Malliani,et al.  Electrical alternation of the T-wave: clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndrome. , 1975, American heart journal.