Prospective Association Between Nut Consumption and Physical Function in Older Men and Women.

BACKGROUND The beneficial effect of nut consumption preventing cardio-metabolic diseases and cancer suggests that nuts might also protect from physical function impairment in older people since aging-related functional decline shares biological pathways with these chronic diseases. The objective was to examine the association between nut consumption and impairment of physical function in older adults. METHODS Prospective study with 3,289 individuals aged ≥60 years from the Seniors-ENRICA cohort. In 2008-2010 and 2012 nut consumption was measured with a validated diet history. Participants were followed-up until 2015 to ascertain incident impaired physical function, specifically impaired agility, mobility, grip strength, gait speed, and overall physical function. Statistical analyses were performed with Cox regression and adjusted for the main confounders, including a wide set of socioeconomic, lifestyle, dietary, and morbidity variables. RESULTS Overall, 65.7% of participants consumed any type of nuts. The mean intake among nut consumers was 15.1 g/d in men and 14.6 g/d in women. Median consumption of nuts was 11.5 g/d in both sexes. Men consuming ≥11.5 g/d of nuts had a lower risk of impaired agility and mobility than those who did not consume nuts; the hazard ratios (95% confidence interval (CI); p for linear trend) were 0.59 (0.39-0.90; p = .01) and 0.50 (0.29-0.90; p = .02), respectively. In women, compared with nonconsumers, the hazard ratio (95% CI; p for linear trend) of impaired overall physical function for nut intake ≥11.5 g/d was 0.65 (0.48-0.87; p = .004). No association was observed between nut consumption and low grip strength and slow gait speed. CONCLUSIONS Nut consumption was associated with half the risk of impaired agility and mobility in men and with a lower risk of overall physical function impairment in women. The suggested protective effect of nut consumption on physical functioning merits further examination.

[1]  C. Franceschi,et al.  The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates , 2018, Front. Med..

[2]  P. Galan,et al.  Association Between Adherence to the Mediterranean Diet at Midlife and Healthy Aging in a Cohort of French Adults , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[3]  A. Newman,et al.  Can a Mediterranean Diet Pattern Slow Aging? , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[4]  L. Fontana,et al.  Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[5]  F. Rodríguez‐Artalejo,et al.  Mediterranean Dietary Patterns and Impaired Physical Function in Older Adults , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[6]  M. Glei,et al.  B-vitamins, carotenoids and α-/γ-tocopherol in raw and roasted nuts. , 2017, Food chemistry.

[7]  M. Drey,et al.  Nutrition, frailty, and sarcopenia , 2017, Aging Clinical and Experimental Research.

[8]  R. Aspden,et al.  Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: a randomized controlled trial12 , 2016, The American journal of clinical nutrition.

[9]  R. Malekzadeh,et al.  Nut consumption and total and cause-specific mortality: results from the Golestan Cohort Study. , 2016, International journal of epidemiology.

[10]  E. Riboli,et al.  Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies , 2016, BMC Medicine.

[11]  J. Martin-Moreno,et al.  Leptin concentration and risk of impaired physical function in older adults: the Seniors-ENRICA cohort. , 2016, Age and ageing.

[12]  M. Cesari,et al.  Frailty and sarcopenia: From theory to clinical implementation and public health relevance. , 2016, European journal of internal medicine.

[13]  W. Willett,et al.  Associations between nut consumption and inflammatory biomarkers. , 2016, The American journal of clinical nutrition.

[14]  Stacey A. Kenfield,et al.  Nut consumption and prostate cancer risk and mortality , 2016, British Journal of Cancer.

[15]  F. Rodríguez‐Artalejo,et al.  Ideal Cardiovascular Health and Risk of Frailty in Older Adults , 2016, Circulation. Cardiovascular quality and outcomes.

[16]  W. Jacob-Filho,et al.  Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial , 2016, European Journal of Nutrition.

[17]  P. Mitchell,et al.  Consumption of nuts and risk of total and cause-specific mortality over 15 years. , 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[18]  D. Mozaffarian,et al.  Effects of tree nuts on blood lipids, apolipoproteins, and blood pressure: systematic review, meta-analysis, and dose-response of 61 controlled intervention trials. , 2015, The American journal of clinical nutrition.

[19]  V. Fulgoni,et al.  Tree Nut consumption is associated with better adiposity measures and cardiovascular and metabolic syndrome health risk factors in U.S. Adults: NHANES 2005–2010 , 2015, Nutrition Journal.

[20]  P. Selby,et al.  The prevalence and outcomes of frailty in older cancer patients: a systematic review. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[21]  G. Grosso,et al.  Nut consumption on all-cause, cardiovascular, and cancer mortality risk: a systematic review and meta-analysis of epidemiologic studies. , 2015, The American journal of clinical nutrition.

[22]  A. C. Cruz Jentoft,et al.  Cognitive aspects of frailty: Mechanisms behind the link between frailty and cognitive impairment , 2015, The journal of nutrition, health & aging.

[23]  M. Falasca,et al.  Cancer chemoprevention with nuts. , 2014, Journal of the National Cancer Institute.

[24]  R. Mattes,et al.  A review of the effects of nuts on appetite, food intake, metabolism, and body weight. , 2014, The American journal of clinical nutrition.

[25]  F. Grodstein,et al.  Long-term intake of nuts in relation to cognitive function in older women , 2014, The Journal of Nutrition, Health & Aging.

[26]  J. Banegas,et al.  Validity and Reproducibility of a Spanish Dietary History , 2014, PloS one.

[27]  E. Regidor,et al.  Justificación y métodos del estudio sobre nutrición y riesgo cardiovascular en España (ENRICA) , 2011 .

[28]  F. Rodríguez‐Artalejo,et al.  [Rationale and methods of the study on nutrition and cardiovascular risk in Spain (ENRICA)]. , 2011, Revista espanola de cardiologia.

[29]  E. Ros.  Health Benefits of Nut Consumption , 2010, Nutrients.

[30]  F. Shahidi,et al.  Natural antioxidants in tree nuts , 2009 .

[31]  P. Casas-Agustench,et al.  Nuts and oxidation: a systematic review. , 2009, Nutrition reviews.

[32]  L. Andersen,et al.  Health benefits of nuts: potential role of antioxidants , 2006, British Journal of Nutrition.

[33]  N. Seeram,et al.  Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacities. , 2006, Journal of agricultural and food chemistry.

[34]  G. Ma,et al.  A Pilot Study on the Effects of Almond Consumption on DNA Damage and Oxidative Stress in Smokers , 2006, Nutrition and cancer.

[35]  J. Blumberg,et al.  Determination of flavonoids and phenolics and their distribution in almonds. , 2006, Journal of agricultural and food chemistry.

[36]  F. Rodríguez‐Artalejo,et al.  Cognitive Assessment of the Non-Demented Elderly Community Dwellers in Spain , 2006, Dementia and Geriatric Cognitive Disorders.

[37]  H. Hubert,et al.  Gender differences in physical disability among an elderly cohort. , 2004, American journal of public health.

[38]  Huiqing Yuan,et al.  Polyphenols from peanut skins and their free radical-scavenging effects. , 2004, Phytochemistry.

[39]  L. Ferrucci,et al.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[40]  S. Boncompagni,et al.  The contribution of reactive oxygen species to sarcopenia and muscle ageing , 2004, Experimental Gerontology.

[41]  Tina Costacou,et al.  Adherence to a Mediterranean diet and survival in a Greek population. , 2003, The New England journal of medicine.

[42]  K Bandeen-Roche,et al.  Self-reported preclinical disability identifies older women with early declines in performance and early disease. , 2001, Journal of clinical epidemiology.

[43]  N Slimani,et al.  Estimation of reproducibility and relative validity of the questions included in the EPIC Physical Activity Questionnaire. , 1997, International journal of epidemiology.

[44]  P. Reaven,et al.  Oxidized low density lipoproteins in atherogenesis: role of dietary modification. , 1996, Annual review of nutrition.

[45]  I. Rosow,et al.  A Guttman health scale for the aged. , 1966, Journal of gerontology.