Migration of potent drugs in wet granulations.

Sodium warfarin tablets prepared by a wet granulation method were shown to be unsatisfactory as to content uniformity due to the migration of the drug substance during the drying period. By using a TLC method, additives were selected which inhibited the migration of the drug substance. The use of these additives with sodium warfarin gave satisfactory tablets as to content uniformity when a wet granulation method was employed.

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