A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models12

[1]  T. Wilt,et al.  Follow‐up of Prostatectomy versus Observation for Early Prostate Cancer , 2017, The New England journal of medicine.

[2]  D. Spandidos,et al.  Anticancer and apoptosis-inducing effects of quercetin in vitro and in vivo , 2017, Oncology reports.

[3]  Xiaoxv Dong,et al.  Simultaneous Determination and Pharmacokinetic Study of Quercetin, Luteolin, and Apigenin in Rat Plasma after Oral Administration of Matricaria chamomilla L. Extract by HPLC-UV , 2017, Evidence-based complementary and alternative medicine : eCAM.

[4]  David Gillatt,et al.  10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer. , 2017, The New England journal of medicine.

[5]  B. Lokeshwar,et al.  Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer. , 2016, Seminars in cancer biology.

[6]  J. Li,et al.  Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer , 2016, Molecular Cancer Therapeutics.

[7]  F. Li,et al.  Flavonoids intake and risk of prostate cancer: a meta‐analysis of observational studies , 2016, Andrologia.

[8]  S. Gadamsetty,et al.  Optimal Dosing for Targeted Therapies in Oncology: Drug Development Cases Leading by Example , 2015, Clinical Cancer Research.

[9]  Xin-yang Wang,et al.  Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis , 2015, Molecular carcinogenesis.

[10]  L. Howells,et al.  Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice , 2015, Science Translational Medicine.

[11]  J. Dwyer,et al.  Recommendations on reporting requirements for flavonoids in research. , 2015, The American journal of clinical nutrition.

[12]  D. Bates,et al.  Regulation of vascular endothelial growth factor in prostate cancer. , 2015, Endocrine-related cancer.

[13]  S. Mudan,et al.  The Concept of Hormesis in Cancer Therapy – Is Less More? , 2015, Cureus.

[14]  Ziyan Wang,et al.  Emerging roles of ATF3 in the suppression of prostate cancer , 2015, Molecular & cellular oncology.

[15]  A. Murakami.  Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents. , 2014, Archives of biochemistry and biophysics.

[16]  B. Bao,et al.  Recent progress on nutraceutical research in prostate cancer , 2014, Cancer and Metastasis Reviews.

[17]  K. Sak.  Cytotoxicity of dietary flavonoids on different human cancer types , 2014, Pharmacognosy reviews.

[18]  R. Thomas,et al.  A double-blind, placebo-controlled randomised trial evaluating the effect of a polyphenol-rich whole food supplement on PSA progression in men with prostate cancer—the UK NCRN Pomi-T study , 2014, Prostate Cancer and Prostatic Disease.

[19]  Wei Zhang,et al.  The von hippel-lindau protein suppresses androgen receptor activity. , 2014, Molecular endocrinology.

[20]  Monique J. Roobol,et al.  Defining the threshold for significant versus insignificant prostate cancer , 2013, Nature Reviews Urology.

[21]  Jorge Sainz,et al.  Consumption of the Dietary Flavonoids Quercetin, Luteolin and Kaempferol and Overall Risk of Cancer - A Review and Meta-Analysis of the Epidemiological Data , 2013 .

[22]  A. Rodriguez-Mateos,et al.  Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. , 2013, Antioxidants & redox signaling.

[23]  L. Luo,et al.  Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3 , 2012, PloS one.

[24]  M. Gleave,et al.  Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer. , 2012, Molecular endocrinology.

[25]  R. Walther,et al.  Effect of the heat shock protein HSP27 on androgen receptor expression and function in prostate cancer cells , 2012, World Journal of Urology.

[26]  G. Yen,et al.  Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities , 2012, Cancer and Metastasis Reviews.

[27]  Ming Yan,et al.  Oral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia. , 2011, European journal of pharmacology.

[28]  Y. Ogata,et al.  Kaempferol stimulates bone sialoprotein gene transcription and new bone formation , 2010, Journal of cellular biochemistry.

[29]  Zhiguo Yu,et al.  Pharmacokinetics of luteolin and tetra-acetyl-luteolin assayed by HPLC in rats after oral administration. , 2010, Biomedical chromatography : BMC.

[30]  A. Scorilas,et al.  KLK5 gene expression is severely upregulated in androgen-independent prostate cancer cells after treatment with the chemotherapeutic agents docetaxel and mitoxantrone , 2010, Biological chemistry.

[31]  A. Kong,et al.  Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. , 2009, Biopharmaceutics & drug disposition.

[32]  Haitao Luo,et al.  Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells , 2009, Nutrition and cancer.

[33]  A. Scorilas,et al.  Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker. , 2009, Clinical chemistry.

[34]  J. Crowley,et al.  Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). , 2009, JAMA.

[35]  Haitao Luo,et al.  Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids , 2008, Nutrition and cancer.

[36]  J. Stewart,et al.  BKM1740, an Acyl-Tyrosine Bisphosphonate Amide Derivative, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells by Inducing Apoptosis , 2008, Clinical Cancer Research.

[37]  D. Lee,et al.  Quercetin suppresses hypoxia‐induced accumulation of hypoxia‐inducible factor‐1α (HIF‐1α) through inhibiting protein synthesis , 2008, Journal of cellular biochemistry.

[38]  S. Eschrich,et al.  Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells , 2006, Clinical Cancer Research.

[39]  M. Neuhouser.  Review: Dietary Flavonoids and Cancer Risk: Evidence From Human Population Studies , 2004, Nutrition and cancer.

[40]  H. Fuse,et al.  Molecular interactions between STAT3 and protein inhibitor of activated STAT3, and androgen receptor. , 2003, Biochemical and biophysical research communications.

[41]  J. Downward,et al.  The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner. , 2000, Journal of cell science.

[42]  J W Moul,et al.  A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate. , 2000, Genomics.

[43]  P. Hollman,et al.  Health effects and bioavailability of dietary flavonols. , 1999, Free radical research.

[44]  L. Hood,et al.  Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2. , 1999, Cancer research.

[45]  R. Hansen,et al.  Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells. , 1997, Biochemical and biophysical research communications.

[46]  C. Bieberich,et al.  Prostate-specific and Androgen-dependent Expression of a Novel Homeobox Gene* , 1996, The Journal of Biological Chemistry.

[47]  D. Tindall,et al.  Hormonal regulation of prostate-specific antigen messenger RNA in human prostatic adenocarcinoma cell line LNCaP. , 1991, Cancer research.

[48]  A. Jemal,et al.  Cancer statistics, 2018 , 2018, CA: a cancer journal for clinicians.

[49]  D. Szostak-Węgierek,et al.  Flavonoids--food sources and health benefits. , 2014, Roczniki Panstwowego Zakladu Higieny.

[50]  J. Hong,et al.  The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. , 2011, The Journal of nutritional biochemistry.

[51]  Jen-kun Lin,et al.  Downregulation of androgen receptor expression by luteolin causes inhibition of cell proliferation and induction of apoptosis in human prostate cancer cells and xenografts , 2008, The Prostate.

[52]  Gary Williamson,et al.  Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. , 2005, The American journal of clinical nutrition.