Normal and abnormal development of the aortic wall and valve: correlation with clinical entities

[1]  M. Goumans,et al.  Bicuspid aortic valve: phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy. , 2014, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[2]  M. Goumans,et al.  Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. , 2014, The Journal of thoracic and cardiovascular surgery.

[3]  A. Nakano,et al.  Nkx2‐5 lineage tracing visualizes the distribution of second heart field‐derived aortic smooth muscle , 2013, Genesis.

[4]  Robert H. Anderson,et al.  Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets , 2013, Cardiovascular research.

[5]  Paul Coucke,et al.  Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD. , 2013, International journal of cardiology.

[6]  A. Franco‐Cereceda,et al.  Impaired Collagen Biosynthesis and Cross‐linking in Aorta of Patients With Bicuspid Aortic Valve , 2013, Journal of the American Heart Association.

[7]  R. Jeremy,et al.  The genetic and molecular basis of bicuspid aortic valve associated thoracic aortopathy: a link to phenotype heterogeneity. , 2013, Annals of cardiothoracic surgery.

[8]  T. Kuntze,et al.  Relation of Bicuspid Aortic Valve Morphology to the Dilatation Pattern of the Proximal Aorta: Focus on the Transvalvular Flow , 2012, Cardiology research and practice.

[9]  M. Goumans,et al.  The arterial and cardiac epicardium in development, disease and repair. , 2012, Differentiation; research in biological diversity.

[10]  V. Kaartinen,et al.  Deficient Signaling via Alk2 (Acvr1) Leads to Bicuspid Aortic Valve Development , 2012, PloS one.

[11]  G. Andelfinger,et al.  Loss of Gata5 in mice leads to bicuspid aortic valve. , 2011, The Journal of clinical investigation.

[12]  R. Hinton,et al.  Heart valve structure and function in development and disease. , 2011, Annual review of physiology.

[13]  G. Vriend,et al.  Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis , 2011, Nature Genetics.

[14]  J. Epstein,et al.  Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves. , 2011, The Journal of clinical investigation.

[15]  S. Kurtovic,et al.  Diverging Alternative Splicing Fingerprints in the Transforming Growth Factor-β Signaling Pathway Identified in Thoracic Aortic Aneurysms , 2011, Molecular medicine.

[16]  A. Goette,et al.  Atrial expression of endothelial nitric oxide synthase in patients with and without atrial fibrillation. , 2010, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[17]  K. Teo,et al.  Association of Bicuspid Aortic Valve Morphology and Aortic Root Dimensions: A Substudy of the Aortic Stenosis Progression Observation Measuring Effects of Rosuvastatin (ASTRONOMER) Study , 2010, Echocardiography.

[18]  Santanu Chakraborty,et al.  Transcriptional Regulation of Heart Valve Progenitor Cells , 2010, Pediatric Cardiology.

[19]  A. C. Durán,et al.  Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities. , 2009, Journal of the American College of Cardiology.

[20]  K. Yutzey,et al.  Heart Valve Development: Regulatory Networks in Development and Disease , 2009, Circulation research.

[21]  A. Al Haj Zen,et al.  Syndromic and non‐syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway , 2009, The Journal of pathology.

[22]  D. Benson Thar's tendons in them thar valves! , 2008, Circulation Research.

[23]  S. Siu,et al.  Outcomes in adults with bicuspid aortic valves. , 2008, JAMA.

[24]  D. Milewicz,et al.  Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction. , 2008, Annual review of genomics and human genetics.

[25]  A. Karsan,et al.  Notch Signaling in Cardiac Development , 2008, Circulation research.

[26]  B. Conley,et al.  Endoglin is required for myogenic differentiation potential of neural crest stem cells. , 2007, Developmental biology.

[27]  Paul Khairy,et al.  Bicuspid aortic valve morphology and interventions in the young. , 2007, Journal of the American College of Cardiology.

[28]  H. Sievers,et al.  A classification system for the bicuspid aortic valve from 304 surgical specimens. , 2007, The Journal of thoracic and cardiovascular surgery.

[29]  Jeffery A. Jones,et al.  xpression of matrix metalloproteinases and endogenous nhibitors within ascending aortic aneurysms of patients ith bicuspid or tricuspid aortic valves , 2007 .

[30]  H. Schäfers,et al.  Endothelial nitric oxide synthase in bicuspid aortic valve disease. , 2007, The Annals of thoracic surgery.

[31]  J. Epstein,et al.  An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. , 2007, The Journal of clinical investigation.

[32]  Robert K. Yu,et al.  Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections (vol 39, pg 1488, 2007) , 2008 .

[33]  V. Garg,et al.  Molecular genetics of aortic valve disease , 2006, Current opinion in cardiology.

[34]  D. Milewicz,et al.  Genetic basis of thoracic aortic aneurysms and aortic dissections , 2005, American journal of medical genetics. Part C, Seminars in medical genetics.

[35]  M. Moon,et al.  The bicuspid aortic valve. , 2005, Current problems in cardiology.

[36]  M. DeRuiter,et al.  Basics of Cardiac Development for the Understanding of Congenital Heart Malformations , 2005, Pediatric Research.

[37]  Joyce Bischoff,et al.  Heart valve development: endothelial cell signaling and differentiation. , 2004, Circulation research.

[38]  Yusuke Nakamura,et al.  Heterozygous TGFBR2 mutations in Marfan syndrome , 2004, Nature Genetics.

[39]  Benjamin R. Arenkiel,et al.  Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development , 2003, Development.

[40]  S. Nakatani,et al.  Failure to Prevent Progressive Dilation of Ascending Aorta by Aortic Valve Replacement in Patients With Bicuspid Aortic Valve: Comparison With Tricuspid Aortic Valve , 2003, Circulation.

[41]  A. Tajik,et al.  Is aortic dilatation an atherosclerosis-related process? Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation. , 2003, Journal of the American College of Cardiology.

[42]  Frank Noack,et al.  Histopathological grading of ascending aortic aneurysm: comparison of patients with bicuspid versus tricuspid aortic valve. , 2003, The Journal of heart valve disease.

[43]  T. Doetschman,et al.  Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-β2–Knockout Mice , 2001 .

[44]  Takayuki Asahara,et al.  The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors , 2001, Nature Medicine.

[45]  E. Boerwinkle,et al.  Familial Thoracic Aortic Aneurysms and Dissections: Genetic Heterogeneity With a Major Locus Mapping to 5q13-14 , 2001, Circulation.

[46]  T. Doetschman,et al.  Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice. , 2001, Circulation.

[47]  D. Schuppan,et al.  Collagens Serve as an Extracellular Store of Bioactive Interleukin 2* , 2000, The Journal of Biological Chemistry.

[48]  T. Mikawa,et al.  Neural crest cells in outflow tract septation of the embryonic chicken heart: Differentiation and apoptosis , 1998, Developmental dynamics : an official publication of the American Association of Anatomists.

[49]  A. Hunter,et al.  A prospective study to assess the frequency of familial clustering of congenital bicuspid aortic valve. , 1997, Journal of the American College of Cardiology.

[50]  D. Bergqvist Ehlers-Danlos type IV syndrome. A review from a vascular surgical point of view. , 1996, The European journal of surgery = Acta chirurgica.

[51]  Ada Hamosh,et al.  Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene , 1991, Nature.

[52]  R. Emanuel,et al.  Congenitally bicuspid aortic valves. Clinicogenetic study of 41 families. , 1978, British heart journal.