Multicenter, Prospective, Randomized Safety and Efficacy Study of a New Atrial‐Based Managed Ventricular Pacing Mode (MVP) in Dual Chamber ICDs

Background: Ventricular desynchronization caused by right ventricular pacing may impair ventricular function and increase risk of heart failure (CHF), atrial fibrillation (AF), and death. Conventional DDD/R mode often results in high cumulative percentage ventricular pacing (Cum%VP). We hypothesized that a new managed ventricular pacing mode (MVP) would safely provide AAI/R pacing with ventricular monitoring and DDD/R during AV block (AVB) and reduce Cum%VP compared to DDD/R.

[1]  M. Kenward,et al.  An Introduction to the Bootstrap , 2007 .

[2]  W. Sauer,et al.  Absent ventricular tachycardia detection in a biventricular implantable cardioverter-defibrillator due to intradevice interaction with a rate smoothing pacing algorithm. , 2004, Heart rhythm.

[3]  Paul A. Belk,et al.  Randomized pilot study of a new atrial-based minimal ventricular pacing mode in dual-chamber implantable cardioverter-defibrillators. , 2004, Heart rhythm.

[4]  J. Nielsen,et al.  Single-lead ventricular pacing is no longer an option for sick sinus syndrome. , 2004, Journal of the American College of Cardiology.

[5]  J. Nielsen,et al.  A randomized comparison of atrial and dual-chamber pacing in 177 consecutive patients with sick sinus syndrome: echocardiographic and clinical outcome. , 2003, Journal of the American College of Cardiology.

[6]  Jürgen Meyer,et al.  Proarrhythmic Effect of Pacemaker Stimulation in Patients With Implanted Cardioverter-Defibrillators , 2003, Circulation.

[7]  G. Lamas,et al.  Adverse Effect of Ventricular Pacing on Heart Failure and Atrial Fibrillation Among Patients With Normal Baseline QRS Duration in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction , 2003, Circulation.

[8]  David O. Martin,et al.  Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. , 2002, JAMA.

[9]  J. Oss,et al.  PROPHYLACTIC IMPLANTATION OF A DEFIBRILLATOR IN PATIENTS WITH MYOCARDIAL INFARCTION AND REDUCED EJECTION FRACTION , 2002 .

[10]  J. Nielsen,et al.  AV Block and Changes in Pacing Mode During Long‐Term Follow‐Up of 399 Consecutive Patients with Sick Sinus Syndrome Treated with an AAI/AAIR Pacemaker , 2001, Pacing and clinical electrophysiology : PACE.

[11]  N. Boyle,et al.  Intradevice Interaction in a Dual Chamber Implantable Cardioverter Defibrillator Preventing Ventricular Tachyarrhythmia Detection , 2000, Journal of cardiovascular electrophysiology.

[12]  H. Calkins,et al.  Analysis of the Pattern of Initiation of Sustained Ventricular Arrhythmias in Patients with Implantable Defibrillators , 2000, Journal of cardiovascular electrophysiology.

[13]  J. Nielsen,et al.  Programming a fixed long atrioventricular delay is not effective in preventing ventricular pacing in patients with sick sinus syndrome. , 1999, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[14]  L. Thuesen,et al.  Atrioventricular conduction during long-term follow-up of patients with sick sinus syndrome. , 1998, Circulation.

[15]  H. Yasui,et al.  Use of Automatic Mode Change Between DDD and AAI to Facilitate Native Atrioventricular Conduction in Patients with Sick Sinus Syndrome or Transient Atrioventricular Block , 1996, Pacing and clinical electrophysiology : PACE.

[16]  C. Pouillot,et al.  Lack of Physiological Adaptation of the Atrioventricular Interval to Heart Rate in Patients Chronically Paced in the AAIR Mode , 1991, Pacing and clinical electrophysiology : PACE.

[17]  P. Brugada,et al.  Pacemaker Syndrome with AAI Rate Variable Pacing: Importance of Atrioventricular Conduction Properties, Medication, and Pacemaker Programmability , 1988, Pacing and clinical electrophysiology : PACE.