Hydroxyalkylation-initiated radical cyclization of N-allylbenzamide for direct construction of isoquinolinone.

A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction of N-allylbenzamide is developed. This reaction proceeds through C(sp(3))-H bond cleavage, oxyalkylation of the double bond, and intramolecular cyclization, which provides a new route toward 4-substituted 3,4-dihydroisoquinolin-1(2H)-one derivatives.

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