The Optic Nerve in Glaucoma

To recognize and to assess glaucomatous changes at the optic nerve, it is important to know the characteristics of the normal optic disc. As in the other biological variables, the appearance of the optic disc varies widely among healthy individuals. This fact is complicate the recognition of the pathological changes. ‘Optic Disc’ is frequently used to describe the portion of the optic nerve clinically visible on examination. This, however, may be slightly inaccurate as ‘disc’ implies a flat, 2 dimensional structure without depth, when in fact the ‘optic nerve head’ is very much a 3 dimensional structure which should ideally be viewed stereoscopically.

[1]  M. F. Armaly.  Genetic determination of cup/disc ratio of the optic nerve. , 1967, Archives of ophthalmology.

[2]  J. Wilensky,et al.  Peripapillary changes in glaucoma. , 1976, American journal of ophthalmology.

[3]  T. Dawber,et al.  The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. , 1980, Survey of ophthalmology.

[4]  J Katz,et al.  Evaluation of nerve fiber layer assessment. , 1984, Archives of ophthalmology.

[5]  J. Jonas,et al.  Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. , 1988, Investigative ophthalmology & visual science.

[6]  G. Dunkelberger,et al.  Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. , 1989, American journal of ophthalmology.

[7]  J. Jonas,et al.  Parapapillary chorioretinal atrophy in normal and glaucoma eyes. II. Correlations. , 1989, Investigative ophthalmology & visual science.

[8]  A. Sommer,et al.  Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. , 1991, Archives of ophthalmology.

[9]  E. Chihara,et al.  Retinal nerve fiber layer defect as an early manifestation of diabetic retinopathy. , 1993, Ophthalmology.

[10]  J. Jonas,et al.  Direct clinico-histological correlation of parapapillary chorioretinal atrophy. , 1993, The British journal of ophthalmology.

[11]  J. Jonas,et al.  Pattern of glaucomatous neuroretinal rim loss. , 1993, Ophthalmology.

[12]  J. Jonas,et al.  Localised wedge shaped defects of the retinal nerve fibre layer in glaucoma. , 1994, The British journal of ophthalmology.

[13]  R. Weinreb.  Diagnosing and monitoring glaucoma with confocal scanning laser ophthalmoscopy. , 1995, Journal of glaucoma.

[14]  Advances in the assessment of optic disc changes in early glaucoma , 1995, Current opinion in ophthalmology.

[15]  Comparison of a Simple Ophthalmoscopic and Planimetric Measurement of Glaucomatous Neuroretinal Rim Areas , 1995, Journal of glaucoma.

[16]  E A Swanson,et al.  Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. , 1995, Archives of ophthalmology.

[17]  J. Jonas,et al.  Evaluation of the retinal nerve fiber layer. , 1996, Survey of ophthalmology.

[18]  R A Hitchings,et al.  Aging changes of the optic nerve head in relation to open angle glaucoma , 1997, The British journal of ophthalmology.

[19]  G. Tomita,et al.  Correlation of the Peripapillary Atrophy Area with Optic Disc Cupping and Disc Hemorrhage , 1998, Journal of glaucoma.

[20]  Peripapillary atrophy in normal and primary open-angle glaucoma. , 1998, Korean journal of ophthalmology : KJO.

[21]  H Uchida,et al.  Increasing peripapillary atrophy is associated with progressive glaucoma. , 1998, Ophthalmology.

[22]  G. Tomita,et al.  Disc hemorrhage and peripapillary atrophy in apparently healthy subjects. , 1999, Acta ophthalmologica Scandinavica.

[23]  J. Jonas,et al.  Ophthalmoscopic evaluation of the optic nerve head. , 1999, Survey of ophthalmology.

[24]  Chris A. Johnson,et al.  The Relationship Between Structural and Functional Alterations in Glaucoma: A Review , 2000, Seminars in ophthalmology.

[25]  J. Jonas,et al.  Ranking of optic disc variables for detection of glaucomatous optic nerve damage. , 2000, Investigative ophthalmology & visual science.

[26]  R. Harper,et al.  The sensitivity and specificity of direct ophthalmoscopic optic disc assessment in screening for glaucoma: a multivariate analysis , 2000, Graefe's Archive for Clinical and Experimental Ophthalmology.

[27]  J. Caprioli,et al.  Ability of Peripapillary Atrophy Parameters to Differentiate Normal-tension Glaucoma From Glaucomalike Disk , 2001, Journal of glaucoma.

[28]  What optic disc parameters are most accurately assessed using the direct ophthalmoscope? , 2001, Eye.

[29]  E. Chaum,et al.  Nerve fiber bundle visual field defect resulting from a giant peripapillary cotton-wool spot. , 2001, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

[30]  J. Caprioli,et al.  Optic disk characteristics before the occurrence of disk hemorrhage in glaucoma patients. , 2001, American journal of ophthalmology.

[31]  E. E. Hartmann,et al.  The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. , 2002, Archives of ophthalmology.

[32]  Chris A. Johnson,et al.  The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. , 2002, Archives of ophthalmology.

[33]  Paul Harasymowycz,et al.  Validity of a new disk grading scale for estimating glaucomatous damage: correlation with visual field damage. , 2002, American journal of ophthalmology.

[34]  Jost B Jonas,et al.  Small neuroretinal rim and large parapapillary atrophy as predictive factors for progression of glaucomatous optic neuropathy. , 2002, Ophthalmology.

[35]  J. Jonas,et al.  Inter-eye differences in chronic open-angle glaucoma patients with unilateral disc hemorrhages. , 2002, Ophthalmology.

[36]  S. Ozdek,et al.  Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry , 2002, Eye.

[37]  George L Spaeth,et al.  Reliability of the disk damage likelihood scale. , 2003, American journal of ophthalmology.

[38]  Young H. Kwon,et al.  Rate of Optic Disc Cup Progression in Treated Primary Open-Angle Glaucoma , 2003, Journal of glaucoma.

[39]  K. Park,et al.  Correlation between a Disc Hemorrhage and Peripapillary Atrophy in Glaucoma Patients with a Unilateral Disc Hemorrhage , 2004, Journal of glaucoma.

[40]  F. Medeiros,et al.  Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma. , 2004, Archives of ophthalmology.

[41]  E. Chihara,et al.  Topographic changes in the optic disc in eyes with cotton-wool spots and primary open-angle glaucoma , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[42]  J. Jonas,et al.  Predictive factors of the optic nerve head for development or progression of glaucomatous visual field loss. , 2004, Investigative ophthalmology & visual science.

[43]  Jost B Jonas,et al.  Ophthalmoscopic evaluation of the parapapillary region of the optic nerve head. , 2004, Klinika oczna.

[44]  Robert N Weinreb,et al.  Retinal nerve fiber layer thickness measurements with scanning laser polarimetry predict glaucomatous visual field loss. , 2004, American journal of ophthalmology.

[45]  Valter Torri,et al.  Results of the European Glaucoma Prevention Study. , 2005, Ophthalmology.

[46]  J. Beiser,et al.  Baseline topographic optic disc measurements are associated with the development of primary open-angle glaucoma: the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study. , 2005, Archives of ophthalmology.

[47]  J. Crowston,et al.  Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma. , 2005, Archives of ophthalmology.

[48]  Jost B Jonas,et al.  Clinical implications of peripapillary atrophy in glaucoma , 2005, Current opinion in ophthalmology.

[49]  Makoto Nakamura,et al.  Comparison of confocal scanning laser ophthalmoscopy, scanning laser polarimetry and optical coherence tomography to discriminate ocular hypertension and glaucoma at an early stage , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[50]  Earl L. Smith,et al.  Scaling the structure--function relationship for clinical perimetry. , 2005, Acta ophthalmologica Scandinavica.

[51]  Douglas R. Anderson,et al.  Acquired peripapillary changes and progression in glaucoma , 1988, Graefe's Archive for Clinical and Experimental Ophthalmology.

[52]  Chris A Johnson,et al.  Evaluation of the structure-function relationship in glaucoma. , 2005, Investigative ophthalmology & visual science.

[53]  Christopher Kai-shun Leung,et al.  Comparative study of retinal nerve fiber layer measurement by StratusOCT and GDx VCC, I: correlation analysis in glaucoma. , 2005, Investigative ophthalmology & visual science.

[54]  F. Medeiros,et al.  Five rules to evaluate the optic disc and retinal nerve fiber layer for glaucoma. , 2005, Optometry.

[55]  RESULTS OF THE EUROPEAN GLAUCOMA PREVENTION STUDY , 2005 .

[56]  Douglas R. Anderson,et al.  Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study. , 2006, Ophthalmology.

[57]  G. Gamble,et al.  Regional correlation of structure and function in glaucoma, using the Disc Damage Likelihood Scale, Heidelberg Retina Tomograph, and visual fields. , 2006, Ophthalmology.

[58]  Robert N Weinreb,et al.  The Impact of the Perimetric Measurement Scale, Sample Composition, and Statistical Method on the Structure-function Relationship in Glaucoma , 2007, Journal of glaucoma.

[59]  R. D'Agostino,et al.  Validated prediction model for the development of primary open-angle glaucoma in individuals with ocular hypertension. , 2007, Ophthalmology.

[60]  F. Medeiros,et al.  Agreement Between Stereophotographic and Confocal Scanning Laser Ophthalmoscopy Measurements of Cup/Disc Ratio: Effect on a Predictive Model for Glaucoma Development , 2007, Journal of glaucoma.

[61]  J. Jonas,et al.  Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study. , 2007, American journal of ophthalmology.

[62]  M. Morales i Ballús,et al.  Baseline Optical Coherence Tomography Predicts the Development of Glaucomatous Change in Glaucoma Suspects , 2007 .

[63]  Robert N Weinreb,et al.  Comparison of HRT-3 glaucoma probability score and subjective stereophotograph assessment for prediction of progression in glaucoma. , 2008, Investigative ophthalmology & visual science.

[64]  R. Ritch,et al.  Anatomic relationships between disc hemorrhage and parapapillary atrophy. , 2008, American journal of ophthalmology.

[65]  S. Miglior,et al.  A Validated Prediction Model for the Development of Primary Open Angle Glaucoma in Individuals with Ocular Hypertension The Ocular Hypertension Treatment Study Group and the European Glaucoma Prevention Study Group , 2008 .

[66]  F. Medeiros,et al.  The Relationship between intraocular pressure and progressive retinal nerve fiber layer loss in glaucoma. , 2009, Ophthalmology.

[67]  A. Ferreras,et al.  Structure–function relationship depends on glaucoma severity , 2009, British Journal of Ophthalmology.

[68]  M. Thiel,et al.  The Disc Damage Likelihood Scale (DDLS): Interobserver Agreement of a New Grading System to Assess Glaucomatous Optic Disc Damage , 2009, Klinische Monatsblatter fur Augenheilkunde.

[69]  Robert N Weinreb,et al.  The glaucoma research community and FDA look to the future: a report from the NEI/FDA CDER Glaucoma Clinical Trial Design and Endpoints Symposium. , 2009, Investigative ophthalmology & visual science.