OBJECTIVES
To examine the cross-sectional associations between serum magnesium (Mg) and hyperuricemia (HU).
METHODS
2904 subjects were included in this study. HU was defined as uric acid ≥416 μmol/L for the male population and ≥360 μmol/L for the female population. A multivariable logistic analysis model was applied to test the associations after adjusting for a number of potential confounding factors.
RESULTS
The relative odds of the prevalence of HU were significantly decreased by 0.65 times in the third quintile of serum Mg (OR 0.65, 95% CI 0.47-0.89), and 0.61 times in the fifth quintile (OR 0.61, 95% CI 0.45-0.83), compared with the lowest quintile: P for trend was 0.002. For males, the relative odds for HU were significantly decreased by 0.61 times in the third quintile of serum Mg (OR 0.61, 95% CI 0.42-0.89), 0.68 times in the fourth quintile (OR 0.68, 95% CI 0.47-0.97), and 0.59 times in the fifth quintile (OR 0.59, 95% CI 0.41-0.84) compared with the lowest quintile: P for trend was 0.003. However, no significant association was observed between serum Mg and HU for females.
CONCLUSION
Serum Mg is inversely associated with HU. This association remains valid for the male subgroup, but not for the female subgroup.