Optoacoustic determination of spatio- temporal responses of ultrasound sensors

The characterization of the spatial and frequency response of acoustic detectors is important for enabling accurate optoacoustic imaging. In this work, we developed a hybrid method for the characterization of the spatially dependent response of ultrasound detectors. The method is based on the experimental determination of the receive-mode electrical impulse response (EIR) of the sensor, which is subsequently convolved with the corresponding spatial impulse response (SIR), computed numerically. The hybrid method is shown to have superior performance over purely experimental techniques in terms of accurate determination of the spatial and temporal responses of ultrasonic detectors, in high as well as low sensitivity regions of the sensor.

[1]  Lester W. Schmerr,et al.  FUNDAMENTAL MODELS AND MEASUREMENTS FOR ULTRASONIC NONDESTRUCTIVE EVALUATION SYSTEMS , 2007 .

[2]  Michael Roumeliotis,et al.  Development and characterization of an omnidirectional photoacoustic point source for calibration of a staring 3D photoacoustic imaging system. , 2009, Optics express.

[3]  Minghua Xu,et al.  Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[4]  Vasilis Ntziachristos,et al.  Multispectral photoacoustic imaging of fluorochromes in small animals. , 2007, Optics letters.

[5]  Vasilis Ntziachristos,et al.  Model-based optoacoustic inversion with arbitrary-shape detectors. , 2011, Medical physics.

[6]  V. Ntziachristos,et al.  Molecular imaging by means of multispectral optoacoustic tomography (MSOT). , 2010, Chemical reviews.

[7]  Dominique Certon,et al.  1D ultrasound array: performance evaluation and characterization by laser interferometry , 2000, 2000 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.00CH37121).

[8]  Vasilis Ntziachristos,et al.  Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging. , 2009, Optics express.

[9]  J. Jensen,et al.  Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers , 1992, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[10]  V. Ntziachristos Going deeper than microscopy: the optical imaging frontier in biology , 2010, Nature Methods.

[11]  J. Jensen,et al.  Modeling transducer impulse responses for predicting calibrated pressure pulses with the ultrasound simulation program Field II. , 2010, The Journal of the Acoustical Society of America.

[12]  Vasilis Ntziachristos,et al.  Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography. , 2012, Radiology.

[13]  Lihong V. Wang,et al.  Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain , 2003, Nature Biotechnology.

[14]  K. Itsumi,et al.  Low acoustic attenuation silicone rubber lens for medical ultrasonic array probe , 2009, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[15]  Ivan Pelivanov,et al.  Focused array transducer for two-dimensional optoacoustic tomography. , 2004, The Journal of the Acoustical Society of America.

[16]  Sung-Jin Song,et al.  Ultrasonic Nondestructive Evaluation Systems: Models and Measurements , 2007 .

[17]  R. Kruger,et al.  Photoacoustic ultrasound (PAUS)--reconstruction tomography. , 1995, Medical physics.

[18]  Vasilis Ntziachristos,et al.  Real-time imaging of cardiovascular dynamics and circulating gold nanorods with multispectral optoacoustic tomography. , 2010, Optics express.

[19]  V. Ntziachristos,et al.  Video rate optoacoustic tomography of mouse kidney perfusion. , 2010, Optics letters.

[20]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[21]  Mathias Fink,et al.  Time deconvolution of diffraction effects ― application to calibration and prediction of transducer waveforms , 1988 .

[22]  Mark A. Anastasio,et al.  An Imaging Model Incorporating Ultrasonic Transducer Properties for Three-Dimensional Optoacoustic Tomography , 2011, IEEE Transactions on Medical Imaging.

[23]  William F Walker,et al.  A method for accurate in silico modeling of ultrasound transducer arrays. , 2009, Ultrasonics.

[24]  Vasilis Ntziachristos,et al.  Fast Semi-Analytical Model-Based Acoustic Inversion for Quantitative Optoacoustic Tomography , 2010, IEEE Transactions on Medical Imaging.

[25]  Lihong V. Wang,et al.  In vivo dark-field reflection-mode photoacoustic microscopy. , 2005, Optics letters.

[26]  V Ntziachristos,et al.  Optoacoustic methods for frequency calibration of ultrasonic sensors , 2011, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[27]  Sun,et al.  Photoacoustic monopole radiation in one, two, and three dimensions. , 1991, Physical review letters.

[28]  Vasilis Ntziachristos,et al.  Sensitivity of molecular target detection by multispectral optoacoustic tomography (MSOT). , 2009, Medical physics.