The Effects of Jp-8 Jet Fuel on Male Sprague-Dawley Rats after a 90-Day Exposure By Oral Gavage

The U.S. Air Force is converting from JP-4 jet fuel to the less volatile JP-8 jet fuel, which is similar to commercial Jet Fuel A. Our previous 90-day inhalation study with JP-8 vapor, using F-344 rats and C57BL/6 mice, resulted in no treatment-related adverse effects other than α 2-microglobin nephropathy in male rats (Mattie et al., 1991). In the present study, male rats were dosed with neat JP-8 (0, 750, 1500, 3000 mg/kg) daily by gavage for 90 days in an effort to characterize the kidney lesion and assess further any additional adverse effects associated with prolonged oral exposure to this fuel. Results of this study revealed a significant dose-dependent decrease in body weights of rats exposed to JP-8. Male rat-specific α 2-microglobin nephropathy was observed by histopathologic examination. A number of significant changes were also seen in blood and urine that were not dose-dependent. Additional treatment-related effects were a gastritis and a perianal dermatitis. Although there were no histopathological or weight changes in the livers of exposed rats, there was an increase in the liver enzymes AST and ALT. The elevated enzymes did not increase with increasing dose of JP-8.

[1]  D. Mattie,et al.  The metabolism of 3-methylheptane in male 344 Fischer rats , 1993 .

[2]  David Brusick,et al.  Mutagen and Oncogen Study on JP-8 , 1978 .

[3]  D. Mattie,et al.  The toxicologic and oncogenic potential of JP-4 jet fuel vapors in rats and mice: 12-month intermittent inhalation exposures. , 1993, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[4]  W. Flamm,et al.  The human relevance of the renal tumor-inducing potential of d-limonene in male rats: implications for risk assessment. , 1991, Regulatory toxicology and pharmacology : RTP.

[5]  C L Alden,et al.  A 90-Day Continuous Vapor Inhalation Toxicity Study of JP-8 Jet Fuel Followed by 20 or 21 Months of Recovery in Fischer 344 Rats and C57BL/6 Mice , 1991, Toxicologic pathology.

[6]  S. G. Kulkarni,et al.  Strain differences in tissue repair response to 1,2-dichlorobenzene , 1996, Archives of Toxicology.

[7]  C L Alden,et al.  A Review of Unique Male Rat Hydrocarbon Nephropathy , 1986, Toxicologic pathology.

[8]  TOXICOLOGIC AND ONCOGENIC POTENTIAL OF JP-4 VAPOR : 90-DAY CONTINUOUS INHALATION EXPOSURE , 1995 .

[9]  C. Alden,et al.  Comparison of short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. , 1987, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[10]  J. Swenberg,et al.  The comparative pathobiology of α2u-globulin nephropathy , 1989 .

[11]  D. Mattie,et al.  Developmental Toxicity of JP‐8 Jet Fuel in the Rat , 1996, Journal of applied toxicology : JAT.

[12]  E. Kinkead,et al.  Acute Irritation and Sensitization Potential of JP-8 Jet Fuel , 1992 .

[13]  E. H. Vernot,et al.  A 90-day vapor inhalation toxicity study of decalin. , 1985, Fundamental and applied toxicology : official journal of the Society of Toxicology.