The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11

Some components of the fission yeast septation initiation network (SIN) localize asymmetrically to spindle pole bodies during anaphase. Symmetric localization of these proteins correlates with cytokinesis defects. It is shown that the SIN-kinase Sid2 mediates SIN asymmetry, in part via the scaffold Cdc11, revealing a previously unknown feedback loop operating to generate SIN asymmetry.

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