Antitumor activity of ropy sour milks in murine solid tumor.

The antitumor effects of lyophilized preparations of three kinds of ropy sour milks, viili, langfil and ropy yoghurt were evaluated in the murine solid tumor system of Sarcoma-180. Intraperitoneal daily injection of the preparations for 9 days after tumor inoculation significantly inhibited tumor growth. Maximum antitumor effect was induced by a dose of 10mg/kg in the viili preparation and 50mg/kg in the langfil preparation. The antitumor activities of the ropy sour milks were completely abrogated by a single pre-treatment of carrageenan. In delayed cutaneous hypersensitivity (DCH) response to oxazolone, the depressed DCH in tumor-bearing mice was significantly enhanced by the injection of three kinds of ropy sour milk. The effective dosage to enhance DCH was almost consistent with that which inhibited tumor growth. These results suggest that the antitumor effect of ropy sour milks may be mediated by the immune responses associated with macrophages and/or T cells. Jpn. J. Zootech. Sci., 61 (11): 1033-1039, 1990

[1]  T. Toba,et al.  Effects of Ropy Sour Milk on the Metastasis of Lewis Lung Carcinoma in Mice , 1988 .

[2]  M. Shenoy,et al.  Antitumor activity of lactic acid bacteria on a solid fibrosarcoma, sarcoma-180 and Ehrlich ascites carcinoma. , 1988, Cancer letters.

[3]  A. Y. Tamime,et al.  Fermented milks and their future trends. Part II. Technological aspects , 1988, Journal of Dairy Research.

[4]  T. Yokokura,et al.  Host-mediated antitumor activity of Lactobacillus casei in mice. , 1984, Gan.

[5]  M. Oda,et al.  Anti-tumor Polysaccharide from Lactobacillus sp. , 1983 .

[6]  K. Shahani,et al.  Antitumor Activity of Fermented Colostrum and Milk. , 1983, Journal of food protection.

[7]  L. Shackelford,et al.  Effect of feeding fermented milk on the incidence of chemically induced colon tumors in rats. , 1983, Nutrition and cancer.

[8]  K. Shahani,et al.  Antitumor component(s) of yogurt: fractionation. , 1981, Journal of dairy science.

[9]  S. Kobayashi,et al.  Antitumor activity of Lactobacillus casei in mice. , 1981, Gan.

[10]  B. Goldin,et al.  Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. , 1980, Journal of the National Cancer Institute.

[11]  G. R. Hemsworth,et al.  Delayed cutaneous hypersensitivity to oxazolone in mice with tumors. , 1978, Cancer research.

[12]  E. Lotzová,et al.  Promotion of incidence of adenovirus type 12 transplantable tumors by carrageenan, a specific antimacrophage agent. , 1977, Journal of the National Cancer Institute.

[13]  R. Keller.  Promotion of tumor growth in vivo by antimacrophage agents. , 1976, Journal of the National Cancer Institute.

[14]  P. Dalev,et al.  Antitumour glycopeptides from Lactobacillus bulgaricus cell wall , 1975, FEBS Letters.

[15]  J. Salvaggio,et al.  Suppression of primary immunization by carrageenan - a macrophage toxic agent. , 1972, Immunological communications.

[16]  J. Salvaggio,et al.  The effect of carrageenan on the establishment of delayed hypersensitivity. , 1971, International archives of allergy and applied immunology.

[17]  R. Carter,et al.  The morphology of immune reactions in normal, thymectomized and reconstituted mice. 3. Response to bacterial antigens: salmonellar flagellar antigen and pneumococcal plysaccharide. , 1970, Immunology.

[18]  H. Schwartz,et al.  The effect of carrageenan on delayed hypersensitivity reactions. , 1969, Journal of immunology.