Dynamic contrast‐enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis

The aim of this study was to investigate the use of magnetic resonance imaging (MRI) for non‐invasive measurement of rectal cancer angiogenesis and hypoxia.

[1]  B. Rosen,et al.  Susceptibility contrast imaging of cerebral blood volume: Human experience , 1991, Magnetic resonance in medicine.

[2]  Evaluation of VEGF expression within breast cancer biopsies & tumour microvasculature assessment by multi-functional dynamic contrast-enhanced MRI , 2004 .

[3]  H. Weinmann,et al.  Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers. , 1984, Physiological chemistry and physics and medical NMR.

[4]  Michael Molls,et al.  Blood perfusion and microenvironment of human tumors : implications for clinical radiooncology , 1998 .

[5]  M V Knopp,et al.  Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging-based parameters and a histomorphological approach in correlation with disease outcome. , 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

[6]  M Kunnen,et al.  Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging--parametric "first-pass" images depict tissue vascularization and perfusion. , 1994, Radiology.

[7]  David L Buckley,et al.  Prediction of radiotherapy outcome using dynamic contrast enhanced MRI of carcinoma of the cervix. , 2002, International journal of radiation oncology, biology, physics.

[8]  A R Padhani,et al.  In vivo monitoring of tumor angiogenesis with MR imaging. , 2000, Academic radiology.

[9]  S. Fox,et al.  Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. , 1996, European journal of cancer.

[10]  D. Collins,et al.  Dynamic magnetic resonance imaging of tumor perfusion , 2004, IEEE Engineering in Medicine and Biology Magazine.

[11]  Borivoj Vojnovic,et al.  Applications of cost-effective spectral imaging microscopy in cancer research , 2003 .

[12]  G Brix,et al.  Assessment of Cerebral Blood Volume with Dynamic Susceptibility Contrast Enhanced Gradient‐Echo Imaging , 1994, Journal of computer assisted tomography.

[13]  B. Rosen,et al.  Perfusion imaging with NMR contrast agents , 1990, Magnetic resonance in medicine.

[14]  A R Padhani,et al.  Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics , 1997, Journal of magnetic resonance imaging : JMRI.

[15]  P. Tofts.  Modeling tracer kinetics in dynamic Gd‐DTPA MR imaging , 1997, Journal of magnetic resonance imaging : JMRI.

[16]  P. Tofts,et al.  Measurement of the blood‐brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts , 1991, Magnetic resonance in medicine.

[17]  G Brix,et al.  Tumor microcirculation evaluated by dynamic magnetic resonance imaging predicts therapy outcome for primary rectal carcinoma. , 2001, Cancer research.

[18]  A. Huvos,et al.  VEGF Expression in Osteosarcoma Correlates with Vascular Permeability by Dynamic MRI , 2004, Clinical orthopaedics and related research.

[19]  Gregory S Karczmar,et al.  MRI of the tumor microenvironment , 2002, Journal of magnetic resonance imaging : JMRI.

[20]  J R Griffiths,et al.  Issues in flow and oxygenation dependent contrast (FLOOD) imaging of tumours , 2001, NMR in biomedicine.

[21]  L D Buadu,et al.  Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathologic findings and tumor angiogenesis. , 1996, Radiology.

[22]  H. Augustin,et al.  Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. , 2000, Cancer research.

[23]  M. Toi,et al.  Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[24]  David J Collins,et al.  Dynamic magnetic resonance imaging of tumor perfusion. Approaches and biomedical challenges. , 2004, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[25]  T Kubota,et al.  Tumor vascularity in the brain: evaluation with dynamic susceptibility-contrast MR imaging. , 1993, Radiology.

[26]  J R Griffiths,et al.  Clinical studies. , 2005, Advances in pharmacology.

[27]  G. Viale,et al.  Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations. , 1995, Cancer research.

[28]  N. Minagawa,et al.  Correlation of plasma level and immunohistochemical expression of vascular endothelial growth factor in patients with advanced colorectal cancer. , 2002, Anticancer research.

[29]  J. Folkman.  What is the evidence that tumors are angiogenesis dependent? , 1990, Journal of the National Cancer Institute.

[30]  S. Hong,et al.  Tumor Angiogenesis as a Prognostic Predictor in Colorectal Carcinoma with Special Reference to Mode of Metastasis and Recurrence , 1998, Oncology.

[31]  A. Padhani,et al.  Non‐invasive methods of assessing angiogenesis and their value in predicting response to treatment in colorectal cancer , 2001, The British journal of surgery.

[32]  E F Halpern,et al.  Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. , 1994, Radiology.

[33]  Orhan Nalcioglu,et al.  Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer , 2003, Journal of magnetic resonance imaging : JMRI.

[34]  A. Harris,et al.  Prognostic significance of a novel hypoxia-regulated marker, carbonic anhydrase IX, in invasive breast carcinoma. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[35]  D. Lampe,et al.  The correlation between immunohistochemically-detected markers of angiogenesis and serum vascular endothelial growth factor in patients with breast cancer. , 2002, Anticancer research.

[36]  C Kremser,et al.  Monitoring of tumor microcirculation during fractionated radiation therapy in patients with rectal carcinoma: preliminary results and implications for therapy. , 2000, Radiology.

[37]  A. Padhani,et al.  Reproducibility of dynamic contrast‐enhanced MRI in human muscle and tumours: comparison of quantitative and semi‐quantitative analysis , 2002, NMR in biomedicine.