Regulation of lactic acid concentration in its bioproduction from wheat flour

Lactic acid is an important molecule for biopolymer production that can be obtained by biological processes. This work deals with the control of the lactic acid concentration in its production bioprocess using wheat flour as substrate. An adaptive control strategy for the simultaneous saccharification, proteins hydrolysis and fermentation (SSPHF) continuous process of lactic acid production is proposed in order to regulate the lactic acid concentration to the target value. The latter is determined so that the lactic acid productivity is maximized. The control strategy effectiveness and robustness are illustrated by means of experimental results.

[1]  C. Ben Youssef,et al.  Modelling and adaptive control strategy in a lactic fermentation process , 2000 .

[2]  Sang Yup Lee,et al.  Kinetic model-based feed-forward controlled fed-batch fermentation of Lactobacillus rhamnosus for the production of lactic acid from Arabic date juice , 2014, Bioprocess and Biosystems Engineering.

[3]  Didier Dumur,et al.  Adaptive Control of Lactic Acid Production Process from Wheat Flour , 2015 .

[4]  Hofvendahl,et al.  Factors affecting the fermentative lactic acid production from renewable resources(1). , 2000, Enzyme and microbial technology.

[5]  G. Roux,et al.  Adaptive predictive control of a continuous fermentation process , 1991 .

[6]  G. Roux,et al.  Modelling and adaptive predictive control of a continuous fermentation process , 1992 .

[7]  F. Lewis,et al.  Optimal and Robust Estimation: With an Introduction to Stochastic Control Theory, Second Edition , 2007 .

[8]  Didier Dumur,et al.  Feedback linearizing controller coupled to an Unscented Kalman filter for lactic acid regulation , 2015, 2015 19th International Conference on System Theory, Control and Computing (ICSTCC).

[9]  Emil Petre,et al.  Sliding mode and adaptive sliding‐mode control of a class of nonlinear bioprocesses , 2007 .

[10]  Emil Petre,et al.  Neural Networks Based Adaptive Control of a Fermentation Bioprocess for Lactic Acid Production , 2011 .

[11]  Juergen Hahn,et al.  Modeling and dynamic optimization of fuel-grade ethanol fermentation using fed-batch process , 2014 .

[12]  Olivier Bernard,et al.  Nonlinear adaptive control for bioreactors with unknown kinetics , 2004, Autom..

[13]  O. Levenspiel The monod equation: A revisit and a generalization to product inhibition situations , 1980 .

[14]  Konrad Reif,et al.  Stochastic stability of the discrete-time extended Kalman filter , 1999, IEEE Trans. Autom. Control..

[15]  Boutaieb Dahhou,et al.  Modelling and estimation aspects of adaptive predictive control in a fermentation process , 1996 .

[16]  Takeshi Kobayashi,et al.  Adaptive on-line optimizing control for lactic acid fermentation , 1990 .

[17]  Daniel Coutinho,et al.  A simple output-feedback strategy for the control of perfused mammalian cell cultures , 2014 .

[18]  S. Niemelä UNCERTAINTY OF QUANTITATIVE DETERMINATIONS DERIVED BY CULTIVATION OF MICROORGANISMS , 2002 .

[19]  Günter Wozny,et al.  Adaptive control of the Simultaneous Saccharification—Fermentation Process from Starch to Ethanol , 2008 .

[20]  Denis Dochain,et al.  Output feedback adaptive extremum seeking control of a continuous stirred tank bioreactor with Monod's kinetics , 2004 .

[21]  Jérôme Harmand,et al.  Nonparametric identification and adaptive control of an anaerobic fluidized bed digester , 2000 .

[22]  Teresa J. Cutright,et al.  Control of a continuous bioreactor using model predictive control , 2005 .

[23]  Rimvydas Simutis,et al.  Bioprocess optimization and control: Application of hybrid modelling , 1994 .

[24]  Y. Tashiro,et al.  Recent advances in lactic acid production by microbial fermentation processes. , 2013, Biotechnology advances.

[25]  G. Goma,et al.  Kinetic Modelling of Lactobacillus casei ssp. rhamnosus Growth and Lactic Acid Production in Batch Cultures Under Various Medium Conditions , 2005, Biotechnology Letters.

[26]  D. Dumur,et al.  Modeling the continuous lactic acid production process from wheat flour , 2015, Applied Microbiology and Biotechnology.

[27]  Rimvydas Simutis,et al.  Generic model control of the specific growth rate in recombinant Escherichia coli cultivations. , 2006, Journal of biotechnology.

[28]  Sihem Tebbani,et al.  Nonlinear control of continuous cultures of Porphyridium purpureum in a photobioreactor , 2015 .