Antimicrobial Susceptibility and Beta-lactamase detection of MRSA in Osogbo. SW Nigeria

A total of 156 Staphylococci aureus isolates from different human clinical specimens comprising urine, stool, skin, wound swabs, ear and nose / nasal swab and blood obtained from patients at two large referral hospitals in Osogbo, Nigeria were screened for their antibiograms and plasmid profiles. A total of six antibiotic resistance profiles were obtained with ten of the isolates showing multi-drug resistance. Plasmids of three size ranges were detected in the isolates. Isolates with high multi-drug resistance profiles were found to possess multiple plasmids with large sizes in the range of 6.5 - 23.2kb. Very high resistance levels (87.5%) were detected against penicillin and tetracycline while vancomycin and gentamicin recorded the least resistance levels of (62.5%) and (6.3%) respectively among the isolates. The starch paper analysis confirmed the presence of beta-lactamase production in all the isolates tested. (Nature and Science. 2007;5(3):44-48). (ISSN: 1545-0740).

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