The dynamic structure of the germinal center.

Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur. However, here Stephanie Camacho and colleagues discuss immunohistological analysis of splenic GCs arising de novo that reveal a more plastic structure.

[1]  G. Nossal,et al.  Antigen-driven B cell differentiation in vivo , 1993, The Journal of experimental medicine.

[2]  A S Perelson,et al.  Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation. , 1993, Immunology today.

[3]  J. Forrester,et al.  Peanut lectin binding properties of germinal centers of mouse lymphoid tissue , 1980, Nature.

[4]  C. Milstein,et al.  Mutation Drift and Repertoire Shift in the Maturation of the Immune Response , 1987, Immunological reviews.

[5]  C. Berek,et al.  Maturation of the immune response in germinal centers , 1991, Cell.

[6]  D. Gray,et al.  Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. , 1992, Journal of immunology.

[7]  Klaus Rajewsky,et al.  Intraclonal generation of antibody mutants in germinal centres , 1991, Nature.

[8]  M. Inaoki,et al.  The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. , 1997, Immunity.

[9]  Kenneth G. C. Smith,et al.  The extent of affinity maturation differs between the memory and antibody‐forming cell compartments in the primary immune response , 1997, The EMBO journal.

[10]  B. Ryffel,et al.  Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling , 1996, The Journal of experimental medicine.

[11]  R. Geha,et al.  Affinity maturation without germinal centres in lymphotoxin-α-deficient mice , 1996, Nature.

[12]  S. Gordon,et al.  Fc chimeric protein containing the cysteine-rich domain of the murine mannose receptor binds to macrophages from splenic marginal zone and lymph node subcapsular sinus and to germinal centers , 1996, The Journal of experimental medicine.

[13]  I. Maclennan,et al.  Germinal centres in T-cell-dependent antibody responses. , 1992, Immunology today.

[14]  H. Zentgraf,et al.  To 'B' or not to 'B' a germinal center? , 1997, Immunology today.

[15]  K. Rajewsky,et al.  Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell‐dependent antigen , 1992, European journal of immunology.

[16]  J. D. Capra,et al.  Analysis of somatic mutation in five B cell subsets of human tonsil , 1994, The Journal of experimental medicine.

[17]  G. Kelsoe,et al.  In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells , 1993, The Journal of experimental medicine.

[18]  C. Berek,et al.  Development of antibody diversity in single germinal centers: selective expansion of high‐affinity variants , 1994, European journal of immunology.