DIOLMYCINS, NEW ANTICOCCIDIAL AGENTS

The structures of diolmycins Al, A2, Bl and B2, novel anticoccidial agents, were determined by spectroscopic analyses. Diolmycins Al and A2 are stereoisomers with the structure of l -(3-indolyl)-4-(/?-hydroxyphenyl)-2,3-butanediol. From the chemical synthesis of the erythro-isomer, the relative configurations of diolmycins Al and A2 were determined to be the erythroand threo-isomevs, respectively. The stereoisomers, diolmycins B l and B2, were also deduced to be erythroand threo1 ,4-di-(/?-hydroxyphenyl)-2, 3-butanediol, respectively.