Determination of Concentration of Methotrexate Enantiomers in Intracellular and Extracellular Fluids of HepG2 Cells by Liquid Chromatography–Tandem Mass Spectrometry

[1]  I. Tucker,et al.  Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. , 2009, Journal of pharmaceutical and biomedical analysis.

[2]  Shou‐Mei Wu,et al.  Simultaneous determination of methotrexate and its eight metabolites in human whole blood by capillary zone electrophoresis. , 2003, Journal of chromatography. A.

[3]  K. Šlais,et al.  Progress in the separation of enantiomers of chiral drugs by TLC without their prior derivatization. , 2001, Die Pharmazie.

[4]  G. Peters,et al.  Basis for effective combination cancer chemotherapy with antimetabolites. , 2000, Pharmacology & therapeutics.

[5]  Choudhury,et al.  Cytogenetic toxicity of methotrexate in mouse bone marrow. , 2000, Environmental toxicology and pharmacology.

[6]  Y. Sugiyama,et al.  Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats. , 1997, Cancer research.

[7]  Y. Tsuda,et al.  Stereoselective renal tubular secretion of carbenicillin , 1993, Antimicrobial Agents and Chemotherapy.

[8]  M. Broggini,et al.  Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid. , 1988, Cancer research.

[9]  R. Schilsky,et al.  High-dose methotrexate: a critical reappraisal. , 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  S. Cramer,et al.  Occurrence and significance of D-methotrexate as a contaminant of commercial methotrexate. , 1984, Cancer research.

[11]  W. Rong Determination of Methotrexate Enantiomers in Human Blood Samples with Capillary Electrophoresis , 2005 .

[12]  H. Brodthagen,et al.  Entero-hepatic cycling of methotrexate estimated by use of the D-isomer as a reference marker , 2004, European Journal of Clinical Pharmacology.

[13]  T. Itoh,et al.  Stereoselectivity of the folate transporter in rabbit small intestine: studies with amethopterin enantiomers. , 2001, Chirality.

[14]  Y. Tsuda,et al.  Stereoselective renal secretion of carbenicillin in rabbits: role of the organic anion transporter at the renal brush border membrane. , 1998, Chirality.