Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity

[1]  V. Chapman,et al.  New mdx mutation disrupts expression of muscle and nonmuscle isoforms of dystrophin , 1993, Nature Genetics.

[2]  L. Kunkel,et al.  The structural and functional diversity of dystrophin , 1993, Nature Genetics.

[3]  P. Briand,et al.  Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice , 1993, Nature.

[4]  J. Towbin,et al.  Duchenne muscular dystrophy , 1993, Neurology.

[5]  J. Chamberlain,et al.  PCR analysis of muscular dystrophy in mdx mice. , 1993, Molecular and cell biology of human diseases series.

[6]  T. Partridge Molecular and Cell Biology of Muscular Dystrophy , 1993, Molecular and Cell Biology of Human Diseases Series.

[7]  J. Ervasti,et al.  Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle , 1992, Nature.

[8]  K. Campbell,et al.  Deficiency of the 50K dystrophin-associated glycoprotein in severe childhood autosomal recessive muscular dystrophy , 1992, Nature.

[9]  K. Davies,et al.  Human dystrophin expression corrects the myopathic phenotype in transgenic mdx mice. , 1992, Human molecular genetics.

[10]  O. Ibraghimov-Beskrovnaya,et al.  Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix , 1992, Nature.

[11]  K. Campbell,et al.  Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice , 1991, The Journal of cell biology.

[12]  T. Partridge Animal models of muscular dystrophy – what can they teach us? , 1991, Neuropathology and applied neurobiology.

[13]  J. Ervasti,et al.  Membrane organization of the dystrophin-glycoprotein complex , 1991, Cell.

[14]  J. Ervasti,et al.  Dystrophin-related protein is localized to neuromuscular junctions of adult skeletal muscle , 1991, Neuron.

[15]  J. Shrager,et al.  The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy , 1991, Nature.

[16]  J. Ervasti,et al.  Purification of dystrophin from skeletal muscle. , 1991, The Journal of biological chemistry.

[17]  J. Faulkner,et al.  Forces and powers of slow and fast skeletal muscles in mice during repeated contractions. , 1991, The Journal of physiology.

[18]  C. Caskey,et al.  Expression of recombinant dystrophin and its localization to the cell membrane , 1991, Nature.

[19]  J. Ervasti,et al.  Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle , 1990, Nature.

[20]  Simon C Watkins,et al.  Dystrophin distribution in heterozygote mdx mice , 1989, Muscle & nerve.

[21]  B. Wold,et al.  Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice , 1989, Molecular and cellular biology.

[22]  E A Barnard,et al.  The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. , 1989, Science.

[23]  V. Chapman,et al.  Recovery of induced mutations for X chromosome-linked muscular dystrophy in mice. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Eric P. Hoffman,et al.  Dystrophin: The protein product of the duchenne muscular dystrophy locus , 1987, Cell.

[25]  J. Johnson,et al.  Transcriptional regulation of the muscle creatine kinase gene and regulated expression in transfected mouse myoblasts , 1986, Molecular and cellular biology.

[26]  B. Hogan,et al.  Manipulating the mouse embryo: A laboratory manual , 1986 .