Influenza A Virus Hemagglutinin–Neuraminidase–Receptor Balance: Preserving Virus Motility

[1]  N. Jacobs,et al.  Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread , 2019, Nature Communications.

[2]  F. V. van Kuppeveld,et al.  The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance , 2019, PLoS pathogens.

[3]  A. Walls,et al.  Structural basis for human coronavirus attachment to sialic acid receptors , 2019, Nature Structural & Molecular Biology.

[4]  J. Yewdell,et al.  Influenza Hemagglutinin and Neuraminidase: Yin–Yang Proteins Coevolving to Thwart Immunity , 2019, Viruses.

[5]  R. Haag,et al.  Force Spectroscopy Shows Dynamic Binding of Influenza Hemagglutinin and Neuraminidase to Sialic Acid. , 2019, Biophysical journal.

[6]  E. Vanstreels,et al.  Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway. , 2019, The Journal of general virology.

[7]  Matthias Müller,et al.  Mobility-Based Quantification of Multivalent Virus-Receptor Interactions: New Insights Into Influenza A Virus Binding Mode. , 2019, Nano letters.

[8]  L. Brown,et al.  Influenza Virus Neuraminidase Structure and Functions , 2019, Front. Microbiol..

[9]  D. Fletcher,et al.  Influenza A virus surface proteins are organized to help penetrate host mucus , 2019, bioRxiv.

[10]  F. V. van Kuppeveld,et al.  Substrate Binding by the Second Sialic Acid-Binding Site of Influenza A Virus N1 Neuraminidase Contributes to Enzymatic Activity , 2018, Journal of Virology.

[11]  J. Paulson,et al.  Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces , 2018, PLoS pathogens.

[12]  S. Lakdawala,et al.  Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity , 2018, The Journal of infectious diseases.

[13]  A. Nanbo,et al.  A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian Cells. , 2018, Cell host & microbe.

[14]  R. Lerner,et al.  A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site , 2018, Nature Communications.

[15]  R. Fouchier,et al.  Transmission routes of respiratory viruses among humans , 2018, Current Opinion in Virology.

[16]  H. Takagi,et al.  Unique Directional Motility of Influenza C Virus Controlled by Its Filamentous Morphology and Short-Range Motions , 2017, Journal of Virology.

[17]  R. Cummings,et al.  The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase , 2017, International journal of molecular sciences.

[18]  Ryan McBride,et al.  Three mutations switch H7N9 influenza to human-type receptor specificity , 2017, PLoS pathogens.

[19]  G. Rimmelzwaan,et al.  Neuraminidase-mediated haemagglutination of recent human influenza A(H3N2) viruses is determined by arginine 150 flanking the neuraminidase catalytic site. , 2017, The Journal of general virology.

[20]  Oliver C. Grant,et al.  New insights into influenza A specificity: an evolution of paradigms. , 2017, Current opinion in structural biology.

[21]  Stephen R. Martin,et al.  Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding , 2017, Journal of Virology.

[22]  T. Sakai,et al.  Influenza A virus hemagglutinin and neuraminidase act as novel motile machinery , 2017, Scientific Reports.

[23]  J. Paulson,et al.  Mutation of the Second Sialic Acid-Binding Site, Resulting in Reduced Neuraminidase Activity, Preceded the Emergence of H7N9 Influenza A Virus , 2017, Journal of Virology.

[24]  Katia Koelle,et al.  Transmission Bottleneck Size Estimation from Pathogen Deep-Sequencing Data, with an Application to Human Influenza A Virus , 2017, Journal of Virology.

[25]  P. Parren,et al.  A novel label-free cell-based assay technology using biolayer interferometry. , 2017, Biosensors & bioelectronics.

[26]  Ryan McBride,et al.  Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity. , 2017, Cell host & microbe.

[27]  Stephen R. Martin,et al.  Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion , 2017, Emerging Microbes &Infections.

[28]  Gregg A. Duncan,et al.  The Mucus Barrier to Inhaled Gene Therapy. , 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

[29]  B. Lina,et al.  Functional balance between neuraminidase and haemagglutinin in influenza viruses. , 2016, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[30]  R. Webby,et al.  An Amino Acid in the Stalk Domain of N1 Neuraminidase Is Critical for Enzymatic Activity , 2016, Journal of Virology.

[31]  D. Bhella,et al.  Filamentous influenza viruses. , 2016, The Journal of general virology.

[32]  J. Rossman,et al.  Filamentous Influenza Viruses , 2016, Current Clinical Microbiology Reports.

[33]  Rommie E. Amaro,et al.  Microsecond Molecular Dynamics Simulations of Influenza Neuraminidase Suggest a Mechanism for the Increased Virulence of Stalk-Deletion Mutants , 2016, The journal of physical chemistry. B.

[34]  R. Webster,et al.  The Interaction between Respiratory Pathogens and Mucus. , 2016, Cell host & microbe.

[35]  J. Paulson,et al.  Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X , 2016, Archives of Virology.

[36]  Timothy B. Stockwell,et al.  Quantifying influenza virus diversity and transmission in humans , 2016, Nature Genetics.

[37]  Richa Gupta,et al.  Physical characterization and profiling of airway epithelial derived exosomes using light scattering. , 2015, Methods.

[38]  Miriam Cohen Notable Aspects of Glycan-Protein Interactions , 2015, Biomolecules.

[39]  Parviez R. Hosseini,et al.  Evolutionary Dynamics and Global Diversity of Influenza A Virus , 2015, Journal of Virology.

[40]  Timothy B. Stockwell,et al.  The soft palate is an important site of adaptation for transmissible influenza viruses , 2015, Nature.

[41]  Xi Chen,et al.  Characterization of Receptor Binding Profiles of Influenza A Viruses Using An Ellipsometry-Based Label-Free Glycan Microarray Assay Platform , 2015, Biomolecules.

[42]  R. DeBiasi,et al.  Emergence of Multidrug-Resistant Influenza A(H1N1)pdm09 Virus Variants in an Immunocompromised Child Treated With Oseltamivir and Zanamivir. , 2015, The Journal of infectious diseases.

[43]  J. McKimm-Breschkin,et al.  The neuraminidases of MDCK grown human influenza A(H3N2) viruses isolated since 1994 can demonstrate receptor binding , 2015, Virology Journal.

[44]  R. Webby,et al.  Pandemic Swine H1N1 Influenza Viruses with Almost Undetectable Neuraminidase Activity Are Not Transmitted via Aerosols in Ferrets and Are Inhibited by Human Mucus but Not Swine Mucus , 2015, Journal of Virology.

[45]  W. Barclay,et al.  One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential , 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

[46]  D. Burke,et al.  Identification of Amino Acid Substitutions Supporting Antigenic Change of Influenza A(H1N1)pdm09 Viruses , 2015, Journal of Virology.

[47]  J. Shelhamer,et al.  Validation of Normal Human Bronchial Epithelial Cells as a Model for Influenza A Infections in Human Distal Trachea , 2015, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[48]  D. Benton,et al.  Biophysical Measurement of the Balance of Influenza A Hemagglutinin and Neuraminidase Activities* , 2015, The Journal of Biological Chemistry.

[49]  Marshall Crumiller,et al.  Influenza A virus transmission bottlenecks are defined by infection route and recipient host. , 2014, Cell host & microbe.

[50]  Yi Shi,et al.  Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses , 2014, Nature Reviews Microbiology.

[51]  K. Braeckmans,et al.  A Beneficiary Role for Neuraminidase in Influenza Virus Penetration through the Respiratory Mucus , 2014, PloS one.

[52]  N. Bastien,et al.  Multiple Influenza A (H3N2) Mutations Conferring Resistance to Neuraminidase Inhibitors in a Bone Marrow Transplant Recipient , 2014, Antimicrobial Agents and Chemotherapy.

[53]  Omer Dushek,et al.  Phenotypic models of T cell activation , 2014, Nature Reviews Immunology.

[54]  G. Air,et al.  Glycomic Characterization of Respiratory Tract Tissues of Ferrets , 2014, The Journal of Biological Chemistry.

[55]  P. Collins,et al.  Enhanced human receptor binding by H5 haemagglutinins , 2014, Virology.

[56]  R. Fouchier,et al.  Role of receptor binding specificity in influenza A virus transmission and pathogenesis , 2014, The EMBO journal.

[57]  G. Gao,et al.  Bat-derived influenza-like viruses H17N10 and H18N11 , 2014, Trends in Microbiology.

[58]  M. Pohl,et al.  Entry of influenza A virus: host factors and antiviral targets. , 2014, The Journal of general virology.

[59]  I. Wilson,et al.  Preferential Recognition of Avian-Like Receptors in Human Influenza A H7N9 Viruses , 2013, Science.

[60]  M. Chan,et al.  Use of ex vivo and in vitro cultures of the human respiratory tract to study the tropism and host responses of highly pathogenic avian influenza A (H5N1) and other influenza viruses. , 2013, Virus research.

[61]  R. Schooley,et al.  Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase , 2013, Virology Journal.

[62]  D. Burke,et al.  Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution , 2013, Science.

[63]  Anice C. Lowen,et al.  Spherical Influenza Viruses Have a Fitness Advantage in Embryonated Eggs, while Filament-Producing Strains Are Selected In Vivo , 2013, Journal of Virology.

[64]  Y. Guan,et al.  Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis , 2013, Influenza and other respiratory viruses.

[65]  W. Barclay,et al.  The Short Stalk Length of Highly Pathogenic Avian Influenza H5N1 Virus Neuraminidase Limits Transmission of Pandemic H1N1 Virus in Ferrets , 2013, Journal of Virology.

[66]  Noriko Kishida,et al.  Characterization of H7N9 influenza A viruses isolated from humans , 2013, Nature.

[67]  T. Tumpey,et al.  Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice , 2013, Nature.

[68]  David F. Smith,et al.  Human H3N2 Influenza Viruses Isolated from 1968 To 2012 Show Varying Preference for Receptor Substructures with No Apparent Consequences for Disease or Spread , 2013, PloS one.

[69]  Yoshihiro Kawaoka,et al.  Receptor binding by a ferret-transmissible H5 avian influenza virus , 2013, Nature.

[70]  J. Yewdell,et al.  Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selection. , 2013, Cell host & microbe.

[71]  G. Air,et al.  Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection , 2013, PLoS pathogens.

[72]  G. Gao,et al.  Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors , 2013, Nature Communications.

[73]  Alan J. Hay,et al.  Evolution of the receptor binding properties of the influenza A(H3N2) hemagglutinin , 2012, Proceedings of the National Academy of Sciences.

[74]  Peter B. Rosenthal,et al.  Distribution of surface glycoproteins on influenza A virus determined by electron cryotomography , 2012, Vaccine.

[75]  D. Hill,et al.  A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia , 2012, Science.

[76]  L. Poon,et al.  Entry of Influenza A Virus with a α2,6-Linked Sialic Acid Binding Preference Requires Host Fibronectin , 2012, Journal of Virology.

[77]  I. Wilson,et al.  Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic , 2012, Journal of Virology.

[78]  A. V. D. van den Heuvel,et al.  Influenza A virus entry into cells lacking sialylated N-glycans , 2012, Proceedings of the National Academy of Sciences.

[79]  D. Marc,et al.  Length Variations in the NA Stalk of an H7N1 Influenza Virus Have Opposite Effects on Viral Excretion in Chickens and Ducks , 2011, Journal of Virology.

[80]  R. Lamb,et al.  Influenza virus assembly and budding. , 2011, Virology.

[81]  Adolfo García-Sastre,et al.  Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway , 2011, PLoS pathogens.

[82]  T. Carpenter,et al.  Emergence and Genetic Variation of Neuraminidase Stalk Deletions in Avian Influenza Viruses , 2011, PloS one.

[83]  J. Yewdell,et al.  Influenza A Virus Hemagglutinin Antibody Escape Promotes Neuraminidase Antigenic Variation and Drug Resistance , 2011, PloS one.

[84]  C. Boucher,et al.  Emergence of a multidrug-resistant pandemic influenza A (H1N1) virus. , 2010, The New England journal of medicine.

[85]  Yan Liu,et al.  Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus , 2010, Journal of Virology.

[86]  R. Fouchier,et al.  The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells , 2010, PLoS pathogens.

[87]  P. Rosenthal,et al.  Structural organization of a filamentous influenza A virus , 2010, Proceedings of the National Academy of Sciences.

[88]  R. Lamb,et al.  Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation , 2010, Journal of Virology.

[89]  J. Andrew McCammon,et al.  Role of Secondary Sialic Acid Binding Sites in Influenza N1 Neuraminidase , 2010, Journal of the American Chemical Society.

[90]  Rahul Raman,et al.  Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift , 2009, Science.

[91]  Ten Feizi,et al.  Receptor-binding specificity of pandemic influenza A (H1N1) 2009 virus determined by carbohydrate microarray , 2009, Nature Biotechnology.

[92]  Gavin J. Wright Signal initiation in biological systems: the properties and detection of transient extracellular protein interactions† †This article is part of a Molecular BioSystems themed issue on Computational and Systems Biology. , 2009, Molecular bioSystems.

[93]  H. Klenk,et al.  Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses , 2009, Archives of Virology.

[94]  David E. Swayne,et al.  Neuraminidase Stalk Length and Additional Glycosylation of the Hemagglutinin Influence the Virulence of Influenza H5N1 Viruses for Mice , 2009, Journal of Virology.

[95]  David F. Smith,et al.  Deletions of neuraminidase and resistance to oseltamivir may be a consequence of restricted receptor specificity in recent H3N2 influenza viruses , 2009, Virology Journal.

[96]  I. Wilson,et al.  Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. , 2008, Journal of molecular biology.

[97]  Nicole M. Bouvier,et al.  The biology of influenza viruses. , 2008, Vaccine.

[98]  L. Kaiser,et al.  Survival of Influenza Virus on Banknotes , 2008, Applied and Environmental Microbiology.

[99]  Wenhui Li,et al.  Influenza A Virus Neuraminidase Limits Viral Superinfection , 2008, Journal of Virology.

[100]  Giovanni Cardone,et al.  Influenza virus pleiomorphy characterized by cryoelectron tomography , 2006, Proceedings of the National Academy of Sciences.

[101]  S. Brody,et al.  Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells , 2006, Journal of Virology.

[102]  Ian A. Wilson,et al.  Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus , 2006, Science.

[103]  Nicolai Bovin,et al.  Receptor specificity of influenza viruses from birds and mammals: new data on involvement of the inner fragments of the carbohydrate chain. , 2005, Virology.

[104]  G. Whittaker,et al.  Influenza virus entry and infection require host cell N-linked glycoprotein , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[105]  H. Klenk,et al.  Neuraminidase Is Important for the Initiation of Influenza Virus Infection in Human Airway Epithelium , 2004, Journal of Virology.

[106]  Feng Zhang,et al.  Assembly of endocytic machinery around individual influenza viruses during viral entry , 2004, Nature Structural &Molecular Biology.

[107]  H. Klenk,et al.  Functional balance between haemagglutinin and neuraminidase in influenza virus infections , 2002, Reviews in medical virology.

[108]  S. Baigent,et al.  Glycosylation of haemagglutinin and stalk-length of neuraminidase combine to regulate the growth of avian influenza viruses in tissue culture. , 2001, Virus research.

[109]  Y. Kawaoka,et al.  Adaptation of Influenza A Viruses to Cells Expressing Low Levels of Sialic Acid Leads to Loss of Neuraminidase Activity , 2001, Journal of Virology.

[110]  R. Webster,et al.  H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity. , 2001, Virology.

[111]  Yoshihiro Kawaoka,et al.  Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into Mammals , 2000, Journal of Virology.

[112]  L. Mitnaul,et al.  Balanced Hemagglutinin and Neuraminidase Activities Are Critical for Efficient Replication of Influenza A Virus , 2000, Journal of Virology.

[113]  Y. Kawaoka,et al.  Influenza A Viruses Lacking Sialidase Activity Can Undergo Multiple Cycles of Replication in Cell Culture, Eggs, or Mice , 2000, Journal of Virology.

[114]  M. Matrosovich,et al.  Intergenic HA-NA interactions in influenza A virus: postreassortment substitutions of charged amino acid in the hemagglutinin of different subtypes. , 2000, Virus research.

[115]  S. Davis,et al.  The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[116]  N. Bovin,et al.  Postreassortment changes in influenza A virus hemagglutinin restoring HA-NA functional match. , 1998, Virology.

[117]  A. van Donkelaar,et al.  Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[118]  R. Bals [Cell types of respiratory epithelium: morphology, molecular biology and clinical significance]. , 1997, Pneumologie.

[119]  J. Skehel,et al.  A surface plasmon resonance assay for the binding of influenza virus hemagglutinin to its sialic acid receptor. , 1996, Virology.

[120]  Y. Kawaoka,et al.  Biologic importance of neuraminidase stalk length in influenza A virus , 1993, Journal of virology.

[121]  G M Whitesides,et al.  Hemagglutinins from two influenza virus variants bind to sialic acid derivatives with millimolar dissociation constants: a 500-MHz proton nuclear magnetic resonance study. , 1989, Biochemistry.

[122]  W G Laver,et al.  An 18-amino acid deletion in an influenza neuraminidase. , 1985, Virology.

[123]  R. Compans,et al.  Sialic acid is incorporated into influenza hemagglutinin glycoproteins in the absence of viral neuraminidase. , 1985, Virus research.

[124]  J. Paulson,et al.  Differential sensitivity of human, avian, and equine influenza A viruses to a glycoprotein inhibitor of infection: selection of receptor specific variants. , 1983, Virology.

[125]  C. Naeve,et al.  Altered tissue tropism of human-avian reassortant influenza viruses. , 1983, Virology.

[126]  J. Paulson,et al.  Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin. , 1983, Virology.

[127]  R. Compans,et al.  Characterization of temperature sensitive influenza virus mutants defective in neuraminidase. , 1974, Virology.

[128]  David F. Smith,et al.  Glycan array analysis of influenza H1N1 binding and release. , 2014, Cancer biomarkers : section A of Disease markers.

[129]  J. Griffith,et al.  Unpacking a gel-forming mucin: a view of MUC5B organization after granular release. , 2010, American journal of physiology. Lung cellular and molecular physiology.

[130]  J. Paulson,et al.  The N2 neuraminidase of human influenza virus has acquired a substrate specificity complementary to the hemagglutinin receptor specificity. , 1991, Virology.