Relationships between Morphology and Viral Etiology in Mammary Tumors of BALB/cfC3H and BALB/cfRIII Mice 1

The morphologic patterns of mammary tumors induced by milk-transmitted C3H and RIII murine mammary tumor viruses (MuMTVs) in BALB/c hosts infected by foster nursing were investigated further and compared taking into account several tumor and host variables. Comparison of BALB/cfC3H and BALB/cfRIII mammary tumors under identical tumor and host conditions showed highly significant differences in subgross morphology and histologic structure. Differences in cytology were also observed. Data suggest that mammary tumor morphology in high cancer strain mice is controlled by the causative MuMTV.

[1]  F. Squartini,et al.  Development, morphology, and progression of mammary tumors during and after fertile life in BALB/cfRIII mice. , 1981, Journal of the National Cancer Institute.

[2]  R. Pingitore.  Stability of Characters of Mammary Tumors in Balb/cfRIII Mice 1 , 1980, Tumori.

[3]  F. Squartini,et al.  Presence and transmission of mammary tumor virus and leukemia virus in the BALB-cfRIII mouse. , 1974, Journal of the National Cancer Institute.

[4]  F. Squartini,et al.  BALB-cfR3: a new high mammary-tumor and high leukemia mouse strain. , 1974, Journal of the National Cancer Institute.

[5]  R. Hallowes,et al.  Tumours of the mammary gland. , 1973, IARC scientific publications.

[6]  W. E. Heston,et al.  Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus , 1971, International journal of cancer.

[7]  J. Wilhelmina,et al.  MORPHOLOGICAL CLASSIFICATION OF MAMMARY TUMOURS IN THE MOUSE. , 1970 .

[8]  W. J. Ebbenhorst Tengbergen.  Morphological classification of mammary tumours in the mouse. , 1970, Pathologia Europaea.

[9]  F. Squartini,et al.  Characters of Mammary Tumours in BALB/c Female Mice Foster-nursed by C3H and RIII Mothers , 1963, Nature.

[10]  M. Olivi,et al.  Sulla morfologia dei tumori mammari da metilcolantrene in topi balb/c privi dell'agente. , 1963 .

[11]  F. Squartini.  Responsiveness and progression of mammary tumors in high-cancer-strain mice. , 1962, Journal of the National Cancer Institute.

[12]  F. Squartini.  Strain differences in growth of mouse mammary tumors. , 1961 .