The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study

[1]  P. Schofield,et al.  Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity , 2018, Mechanisms of Ageing and Development.

[2]  Piero Fariselli,et al.  PhD-SNPg: a webserver and lightweight tool for scoring single nucleotide variants , 2017, Nucleic Acids Res..

[3]  Edmund Jones,et al.  A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design , 2017, European Journal of Human Genetics.

[4]  Lijun Wang,et al.  Association of Klotho single nucleotide polymorphisms with cardiovascular diseases : a systematic review and meta-analysis , 2017 .

[5]  Jaroslav Bendl,et al.  PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions , 2016, PLoS Comput. Biol..

[6]  M. Gerstein,et al.  Role of non-coding sequence variants in cancer , 2016, Nature Reviews Genetics.

[7]  Hee-Kwon Kim,et al.  Lack of functional KL-VS polymorphism of the KLOTHO gene in the Korean population. , 2016, Genetics and molecular biology.

[8]  Yongwook Choi,et al.  PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels , 2015, Bioinform..

[9]  Tugba G. Kucukkal,et al.  Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins. , 2015, Current opinion in structural biology.

[10]  Tugba G. Kucukkal,et al.  On Human Disease‐Causing Amino Acid Variants: Statistical Study of Sequence and Structural Patterns , 2015, Human mutation.

[11]  Xiaohui Xie,et al.  DANN: a deep learning approach for annotating the pathogenicity of genetic variants , 2015, Bioinform..

[12]  Colin Campbell,et al.  An integrative approach to predicting the functional effects of non-coding and coding sequence variation , 2015, Bioinform..

[13]  Kevin Y. Yip,et al.  FunSeq2: a framework for prioritizing noncoding regulatory variants in cancer , 2014, Genome Biology.

[14]  L. Mucke,et al.  Life Extension Factor Klotho Enhances Cognition , 2016 .

[15]  E. Zeggini,et al.  Functional annotation of non-coding sequence variants , 2014, Nature Methods.

[16]  J. Shendure,et al.  A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.

[17]  C. Abraham,et al.  Biochemical and Functional Characterization of the Klotho-VS Polymorphism Implicated in Aging and Disease Risk* , 2013, The Journal of Biological Chemistry.

[18]  I. Adzhubei,et al.  Predicting Functional Effect of Human Missense Mutations Using PolyPhen‐2 , 2013, Current protocols in human genetics.

[19]  Eurie L. Hong,et al.  Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.

[20]  M. Izadi,et al.  Absence of kl-vs Variant of Klotho Gene in Iranian Cardiac Patients (Comparison to the World Populations) , 2011, Disease markers.

[21]  Russ B. Altman,et al.  Improving the prediction of disease-related variants using protein three-dimensional structure , 2011, BMC Bioinformatics.

[22]  D. Mellström,et al.  Prevalence of Primary Hyperparathyroidism and Impact on Bone Mineral Density in Elderly Men: MrOs Sweden , 2011, World Journal of Surgery.

[23]  D. Nagaraja,et al.  Association of the functional KL-VS variant of Klotho gene with early-onset ischemic stroke. , 2010, Biochemical and biophysical research communications.

[24]  C. Franceschi,et al.  The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect , 2010, Biogerontology.

[25]  M. Wolf,et al.  Klotho Variants and Chronic Hemodialysis Mortality , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[26]  Predrag Radivojac,et al.  Automated inference of molecular mechanisms of disease from amino acid substitutions , 2009, Bioinform..

[27]  N. Hamajima,et al.  KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects. , 2009, Clinica chimica acta; international journal of clinical chemistry.

[28]  F. Collins,et al.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits , 2009, Proceedings of the National Academy of Sciences.

[29]  S. Henikoff,et al.  Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm , 2009, Nature Protocols.

[30]  V. Novelli,et al.  Lack of replication of genetic associations with human longevity , 2008, Biogerontology.

[31]  C. Kuo,et al.  Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging , 2007, Science.

[32]  G. Kantarci,et al.  Klotho: an antiaging protein involved in mineral and vitamin D metabolism. , 2007, Kidney international.

[33]  L. Hansson,et al.  Evaluation of Gentian cystatin C reagent on Abbott Ci8200 and calculation of glomerular filtration rate expressed in mL/min/1.73 m2 from the cystatin C values in mg/L , 2007, Scandinavian journal of clinical and laboratory investigation.

[34]  K. Okawa,et al.  Klotho converts canonical FGF receptor into a specific receptor for FGF23 , 2006, Nature.

[35]  K. Sung,et al.  The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. , 2006, Metabolism: clinical and experimental.

[36]  Won-Young Lee,et al.  Relationship between polymorphisms G395A in promoter and C1818T in exon 4 of the KLOTHO gene with glucose metabolism and cardiovascular risk factors in Korean women , 2006, Journal of endocrinological investigation.

[37]  Peng Yue,et al.  SNPs3D: Candidate gene and SNP selection for association studies , 2006, BMC Bioinformatics.

[38]  David Haussler,et al.  LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources , 2005, Bioinform..

[39]  D. Arking,et al.  Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity , 2005, Circulation research.

[40]  Mark Daly,et al.  Haploview: analysis and visualization of LD and haplotype maps , 2005, Bioinform..

[41]  D. Arking,et al.  KLOTHO allele status and the risk of early-onset occult coronary artery disease. , 2003, American journal of human genetics.

[42]  Y. Takeuchi,et al.  Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. , 2002, The Journal of clinical endocrinology and metabolism.

[43]  I. Mian,et al.  Association of human aging with a functional variant of klotho , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[44]  D. Chasman,et al.  Predicting the functional consequences of non-synonymous single nucleotide polymorphisms: structure-based assessment of amino acid variation. , 2001, Journal of molecular biology.

[45]  R. Nagai,et al.  In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. , 2000, Biochemical and biophysical research communications.

[46]  R. Nagai,et al.  Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. , 1998, Biochemical and biophysical research communications.

[47]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.