Erythropoietin receptor signaling processes

[1]  W. P. Hanratty,et al.  The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus , 1993, Molecular and General Genetics MGG.

[2]  Satoru Takahashi,et al.  Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality. , 2002, Blood.

[3]  S. Goldman,et al.  Erythropoietin strikes a new cord , 2002, Nature Medicine.

[4]  M. Arcasoy,et al.  A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. , 2002, Blood.

[5]  Chris P. Miller,et al.  Erythropoietin receptor-dependent erythroid colony-forming unit development: capacities of Y343 and phosphotyrosine-null receptor forms. , 2002, Blood.

[6]  K. Flanders,et al.  Erythropoietin receptor signalling is required for normal brain development. , 2002, Development.

[7]  K. Ozawa,et al.  Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation. , 2002 .

[8]  S. Colley,et al.  Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells. , 2001, Archives of biochemistry and biophysics.

[9]  H. Lodish,et al.  The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. , 2001, Molecular cell.

[10]  H. Lodish,et al.  Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. , 2001, Blood.

[11]  H. Lodish,et al.  Erythropoiesis in the absence of janus-kinase 2: BCR-ABL induces red cell formation in JAK2(-/-) hematopoietic progenitors. , 2001, Blood.

[12]  M. Birnbaum,et al.  Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice* , 2001, The Journal of Biological Chemistry.

[13]  T. Ishida,et al.  Src transduces erythropoietin‐induced differentiation signals through phosphatidylinositol 3‐kinase , 2001, The EMBO journal.

[14]  S. Barnache,et al.  Alterations of the phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways in the erythropoietin-independent Spi-1/PU.1 transgenic proerythroblasts. , 2001, Blood.

[15]  R. Kralovics,et al.  Genetic heterogeneity of primary familial and congenital polycythemia , 2001, American journal of hematology.

[16]  I. Roninson,et al.  Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. , 2001, Genes & development.

[17]  N. Miyasaka,et al.  CrkL Is Recruited through Its SH2 Domain to the Erythropoietin Receptor and Plays a Role in Lyn-mediated Receptor Signaling* , 2001, The Journal of Biological Chemistry.

[18]  Stuart A. Lipton,et al.  Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades , 2001, Nature.

[19]  F. Quelle,et al.  DNA damage-induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway. , 2001, Blood.

[20]  J. Ihle,et al.  The distal region and receptor tyrosines of the Epo receptor are non‐essential for in vivo erythropoiesis , 2001, The EMBO journal.

[21]  K. Kaestner,et al.  Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .

[22]  H. Lodish,et al.  Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[23]  P. Lewczuk,et al.  Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[24]  J. Williams,et al.  Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn. , 2001, Cancer research.

[25]  M. Malumbres,et al.  Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development , 2001, Molecular and Cellular Biology.

[26]  H. Lodish,et al.  The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif. , 2001, Molecular cell.

[27]  Ursula Klingmüller,et al.  Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor , 2001, Current Biology.

[28]  Josef M. Penninger,et al.  CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling , 2001, Nature.

[29]  C. Noguchi,et al.  Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts* , 2000, The Journal of Biological Chemistry.

[30]  H. Sakamoto,et al.  Mitogen-activated Protein Kinase Plays an Essential Role in the Erythropoietin-dependent Proliferation of CTLL-2 Cells* , 2000, The Journal of Biological Chemistry.

[31]  H. Beug,et al.  Protein Kinase C α Controls Erythropoietin Receptor Signaling* , 2000, The Journal of Biological Chemistry.

[32]  J. Ward,et al.  Ras-Guanine Nucleotide Exchange Factor Sos2 Is Dispensable for Mouse Growth and Development , 2000, Molecular and Cellular Biology.

[33]  J. Ryan,et al.  JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells. , 2000, Blood.

[34]  K. Ozawa,et al.  A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction. , 2000, Blood.

[35]  C. Lacombe,et al.  Proteasomes Regulate the Duration of Erythropoietin Receptor Activation by Controlling Down-regulation of Cell Surface Receptors* , 2000, The Journal of Biological Chemistry.

[36]  C. Hanson,et al.  Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins , 2000, Journal of Virology.

[37]  S. Klinken,et al.  HS1 Interacts with Lyn and Is Critical for Erythropoietin-induced Differentiation of Erythroid Cells* , 2000, The Journal of Biological Chemistry.

[38]  T. N. Palmer,et al.  Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo , 2000, Oncogene.

[39]  A. Yoshimura,et al.  The Jak-Stat pathway in normal and perturbed hematopoiesis. , 2000, Blood.

[40]  J. Price,et al.  Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin. , 1999, Blood.

[41]  R. Gregory,et al.  Signal transduction in the erythropoietin receptor system. , 1999, Experimental cell research.

[42]  J. Kere,et al.  Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state. , 1999, Blood.

[43]  H. Pendeville,et al.  SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis , 1999, Cell.

[44]  Paul J Hertzog,et al.  SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine , 1999, Cell.

[45]  T. Koike,et al.  Phosphatidylinositol 3-kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis. , 1999, Blood.

[46]  A. Mui,et al.  STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells , 1999, The EMBO journal.

[47]  F. Prósper,et al.  Erythropoietin Can Induce the Expression of Bcl-xLthrough Stat5 in Erythropoietin-dependent Progenitor Cell Lines* , 1999, The Journal of Biological Chemistry.

[48]  K. Todokoro,et al.  Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis. , 1999, Blood.

[49]  H. Lodish,et al.  Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice A Direct Role for Stat5 in Bcl-XL Induction , 1999, Cell.

[50]  F. Gouilleux,et al.  IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line , 1999, Oncogene.

[51]  S. O. Smith,et al.  Activation of the erythropoietin receptor by the gp55‐P viral envelope protein is determined by a single amino acid in its transmembrane domain , 1999, The EMBO journal.

[52]  J. Johnston,et al.  Cytokine‐inducible SH2 protein‐3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N‐terminal kinase inhibitory region as well as SH2 domain , 1999, Genes to cells : devoted to molecular & cellular mechanisms.

[53]  A. Wickrema,et al.  Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). , 1999, Blood.

[54]  D. Ribatti,et al.  Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo , 1999 .

[55]  A. Yoshimura,et al.  The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop , 1999, The EMBO journal.

[56]  I. Wilson,et al.  Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. , 1999, Science.

[57]  I. Wilson,et al.  Erythropoietin receptor activation by a ligand-induced conformation change. , 1999, Science.

[58]  Stefan N. Constantinescu,et al.  The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction , 1999, Trends in Endocrinology & Metabolism.

[59]  P. Mayeux,et al.  Physical and Functional Interaction between p72 syk and Erythropoietin Receptor* , 1998, The Journal of Biological Chemistry.

[60]  A. Yoshimura,et al.  Proteasomes Regulate Erythropoietin Receptor and Signal Transducer and Activator of Transcription 5 (STAT5) Activation , 1998, The Journal of Biological Chemistry.

[61]  H. Broxmeyer,et al.  Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells , 1998, Molecular and Cellular Biology.

[62]  F. Gouilleux,et al.  A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B , 1998, Molecular and Cellular Biology.

[63]  Robert M. Stroud,et al.  Efficiency of signalling through cytokine receptors depends critically on receptor orientation , 1998, Nature.

[64]  Y Nagata,et al.  Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. , 1998, Blood.

[65]  D. Chang,et al.  Inhibition of Stat1-mediated gene activation by PIAS1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Z. Zhao,et al.  Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis , 1998 .

[67]  T. Hirano,et al.  A novel function of Stat1 and Stat3 proteins in erythropoietin-induced erythroid differentiation of a human leukemia cell line. , 1998, Blood.

[68]  R. Kralovics,et al.  Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia. , 1998, The Journal of clinical investigation.

[69]  G. Krystal,et al.  Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. , 1998, Genes & development.

[70]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[71]  N. Miyasaka,et al.  Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. , 1998, Blood.

[72]  A. Cumano,et al.  Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis , 1998, Cell.

[73]  J. Marine,et al.  Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors , 1998, Cell.

[74]  H. Lodish,et al.  The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. , 1998, Blood.

[75]  C. Hanson,et al.  Both the Polycythemia- and Anemia-Inducing Strains of Friend Spleen Focus-Forming Virus Induce Constitutive Activation of the Raf-1/Mitogen-Activated Protein Kinase Signal Transduction Pathway , 1998, Journal of Virology.

[76]  M. Bernard,et al.  BCR-ABL and constitutively active erythropoietin receptor (cEpoR) activate distinct mechanisms for growth factor-independence and inhibition of apoptosis in Ba/F3 cell line , 1998, Oncogene.

[77]  P Jay,et al.  Specific inhibition of Stat3 signal transduction by PIAS3. , 1997, Science.

[78]  R Berger,et al.  A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. , 1997, Science.

[79]  R. Barrett,et al.  Increased potency of an erythropoietin peptide mimetic through covalent dimerization , 1997, Nature Biotechnology.

[80]  C. Lacombe,et al.  Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2 , 1997, The Journal of Biological Chemistry.

[81]  K. Kishi,et al.  Primary familial polycythaemia associated with a novel point mutation in the erythropoietin receptor , 1997, British journal of haematology.

[82]  R. Kucherlapati,et al.  K-ras is an essential gene in the mouse with partial functional overlap with N-ras. , 1997, Genes & development.

[83]  P. Marynen,et al.  Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. , 1997, Blood.

[84]  D. Wojchowski,et al.  Hematopoietic cell phosphatase negatively regulates erythropoietin-induced hemoglobinization in erythroleukemic SKT6 cells. , 1997, Blood.

[85]  S. Orkin,et al.  A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development , 1997, Molecular and cellular biology.

[86]  R. Kralovics,et al.  Two new EPO receptor mutations: truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias. , 1997, Blood.

[87]  E. Nishida,et al.  Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3. , 1997, Blood.

[88]  R. Snell,et al.  Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[89]  S. Akira,et al.  Structure and function of a new STAT-induced STAT inhibitor , 1997, Nature.

[90]  Takaho A. Endo,et al.  A new protein containing an SH2 domain that inhibits JAK kinases , 1997, Nature.

[91]  M. Arcasoy,et al.  Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. , 1997, Blood.

[92]  I. Kerr,et al.  Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop , 1997, Molecular and cellular biology.

[93]  A. Yoshimura,et al.  CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. , 1997, Blood.

[94]  E. Nishida,et al.  Activation of JNK signaling pathway by erythropoietin, thrombopoietin, and interleukin-3. , 1997, Blood.

[95]  A. Burnett,et al.  Mutant N-RAS Induces Erythroid Lineage Dysplasia in Human CD34+ Cells , 1997, The Journal of experimental medicine.

[96]  S. Klinken,et al.  Lyn tyrosine kinase is essential for erythropoietin‐induced differentiation of J2E erythroid cells , 1997, The EMBO journal.

[97]  H. Lodish,et al.  Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[98]  H. Lodish,et al.  Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[99]  L. Hennighausen,et al.  Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.

[100]  Peter Beighton,et al.  de la Chapelle, A. , 1997 .

[101]  D. Chang,et al.  Activation of the Erythropoietin (EPO) Receptor by Bivalent Anti-EPO Receptor Antibodies* , 1996, The Journal of Biological Chemistry.

[102]  B. Groner,et al.  Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype , 1996, Molecular and cellular biology.

[103]  L. Zon,et al.  Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[104]  U Klingmüller,et al.  Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[105]  Ronald W. Barrett,et al.  Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin , 1996, Science.

[106]  B. Groner,et al.  Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. , 1996, The EMBO journal.

[107]  W. Vainchenker,et al.  Spi-1/PU.1 transgenic mice develop multistep erythroleukemias , 1996, Molecular and cellular biology.

[108]  D. Alexander,et al.  CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation , 1996, The Journal of experimental medicine.

[109]  A. Levitzki,et al.  Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor , 1996, Nature.

[110]  V. D’Agati,et al.  Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. , 1996, Genes & development.

[111]  J. Krosl,et al.  Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. , 1995, The EMBO journal.

[112]  P. Mayeux,et al.  The signal transduction pathway of erythropoietin involves three forms of mitogen-activated protein (MAP) kinase in UT7 erythroleukemia cells. , 1995, European journal of biochemistry.

[113]  S. Stacker,et al.  Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease , 1995, Cell.

[114]  G. Krystal,et al.  Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3-Kinase and for EpR-associated PI 3-Kinase Activity (*) , 1995, The Journal of Biological Chemistry.

[115]  Rudolf Jaenisch,et al.  Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor , 1995, Cell.

[116]  H. Mano,et al.  Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. , 1995, Oncogene.

[117]  G. Semenza,et al.  Primary familial polycythemia: a frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin. , 1995, Blood.

[118]  A. Miyajima,et al.  Interleukin 2 and erythropoietin activate STAT5/MGF via distinct pathways. , 1995, The EMBO journal.

[119]  N. Copeland,et al.  A novel cytokine‐inducible gene CIS encodes an SH2‐containing protein that binds to tyrosine‐phosphorylated interleukin 3 and erythropoietin receptors. , 1995, The EMBO journal.

[120]  Ursula Klingmüller,et al.  Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals , 1995, Cell.

[121]  R. Kucherlapati,et al.  The murine N-ras gene is not essential for growth and development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[122]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[123]  D. Hilton,et al.  Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[124]  N. Aoki,et al.  Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. , 1994, The Journal of biological chemistry.

[125]  K. Siminovitch,et al.  Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. , 1994, Clinical immunology and immunopathology.

[126]  D. Barber,et al.  Erythropoietin and interleukin-2 activate distinct JAK kinase family members , 1994, Molecular and cellular biology.

[127]  P. Lansdorp,et al.  CD45 isoform expression on human haemopoietic cells at different stages of development , 1994, British journal of haematology.

[128]  H. Lodish,et al.  Activation and inhibition of erythropoietin receptor function: role of receptor dimerization , 1994, Molecular and cellular biology.

[129]  A. D’Andrea,et al.  Mutation in the negative regulatory element of the erythropoietin receptor gene in a case of sporadic primary polycythemia. , 1994, Experimental hematology.

[130]  K. Yamamura,et al.  Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[131]  A. Yoshimura,et al.  Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[132]  O. Silvennoinen,et al.  JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin , 1993, Cell.

[133]  T. Mak,et al.  Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice , 1993, Cell.

[134]  D. Beier,et al.  Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene , 1993, Cell.

[135]  T. Pawson,et al.  Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor. , 1993, Blood.

[136]  K. Siminovitch,et al.  Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene , 1993, Nature Genetics.

[137]  A. de la Chapelle,et al.  Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[138]  H. Lodish,et al.  Structure, function, and activation of the erythropoietin receptor. , 1993, Blood.

[139]  H. Lodish,et al.  Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor growth. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[140]  A. Chapelle,et al.  Familial erythrocytosis genetically linked to erythropoietin receptor gene , 1993, The Lancet.

[141]  L. Zon,et al.  The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein , 1992, Molecular and cellular biology.

[142]  H. Lodish,et al.  Homodimerization and constitutive activation of the erythropoietin receptor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[143]  H. Lodish,et al.  An activating mutation in the murine erythropoietin receptor induces erythroleukemia in mice: A cytokine receptor superfamily oncogene , 1991, Cell.

[144]  M. McMahon,et al.  Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. , 1991, The Journal of biological chemistry.

[145]  V. Broudy,et al.  Erythropoietin receptor characteristics on primary human erythroid cells. , 1991, Blood.

[146]  H. Lodish,et al.  Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity , 1990, Nature.

[147]  C. Eaves,et al.  Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow , 1990, The Journal of experimental medicine.

[148]  S. Chung,et al.  Transmembrane domain of the envelope gene of a polycythemia-inducing retrovirus determines erythropoietin-independent growth. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[149]  J. L. Bos,et al.  ras oncogenes in human cancer: a review. , 1989, Cancer research.

[150]  S. Krantz,et al.  Identification of the receptor for erythropoietin by cross-linking to Friend virus-infected erythroid cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[151]  D. Kabat,et al.  Loss of leukemogenicity caused by mutations in the membrane glycoprotein structural gene of Friend spleen focus-forming virus. , 1983, Proceedings of the National Academy of Sciences of the United States of America.