Effects of timing and dose of vitamin A on tissue retinol concentrations and antibody production in the previously vitamin A-depleted rats.

The effect of retinol repletion in previously vitamin A-depleted Lewis rats on antibody production to pneumococcal polysaccharide (SSS-III) was studied. When vitamin A-depleted rats were given either 0.35 mumol (0.1 mg) or 5.2 mumol (1.5 mg) retinol, plasma retinol became normal within 8 h. Liver and lymphoid-organ retinol concentrations were normalized by 1 d after repletion with 5.2 mumol but not 0.35 mumol retinol. Antibody production to SSS-III was compared after administering 5.2 mumol retinol either as a divided dose (half given 4 d before and half given on the day of immunization) or as a single dose concurrent with immunization. Vitamin A-depleted rats produced very little SSS-III-specific antibody. The divided dose of retinol consistently restored anti-SSS-III production whereas the single concurrent dose was less effective despite equal effects on tissue retinol concentrations. Interestingly, normalization of plasma retinol was not always a good predictor of the immune response to pneumococcal polysaccharide.

[1]  C. Taylor,et al.  Immunological memory to tetanus toxoid is established and maintained in the vitamin A‐depleted rat , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  C. Taylor,et al.  Vitamin A status and the immune response to pneumococcal polysaccharide: effects of age and early stages of retinol deficiency in rats. , 1991, The Journal of nutrition.

[3]  B. Prakasam,et al.  Effect of massive dose vitamin A on morbidity and mortality in Indian children , 1990, The Lancet.

[4]  A. Sommer,et al.  Tolerance of preschoolers to two dosage strengths of vitamin A preparation. , 1990, The American journal of clinical nutrition.

[5]  G. Hussey,et al.  A randomized, controlled trial of vitamin A in children with severe measles. , 1990, The New England journal of medicine.

[6]  C. Taylor,et al.  Antibody production in vitamin A‐depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  Martin W. Bloem,et al.  Mild vitamin A deficiency and risk of respiratory tract diseases and diarrhea in preschool and school children in northeastern Thailand. , 1990, American journal of epidemiology.

[8]  D. Thurnham.  Vitamin A deficiency and its role in infection. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[9]  R. Mahley,et al.  Chylomicron-chylomicron remnant clearance by liver and bone marrow in rabbits. Factors that modify tissue-specific uptake. , 1989, The Journal of biological chemistry.

[10]  D. Sklan,et al.  Antigen-specific immune response impairment in the chick as influenced by dietary vitamin A. , 1989, The Journal of nutrition.

[11]  C. Taylor,et al.  Vitamin A depletion and repletion: effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III). , 1989, The American journal of clinical nutrition.

[12]  M. Forman,et al.  Conjunctival impression cytology: feasibility of a field trial to detect subclinical vitamin A deficiency. , 1989, The American journal of clinical nutrition.

[13]  A. Sommer,et al.  Vitamin A and infection: public health implications. , 1989, Annual review of nutrition.

[14]  D. Karyadi,et al.  Vitamin A-fortified monosodium glutamate and vitamin A status: a controlled field trial. , 1988, The American journal of clinical nutrition.

[15]  D. Karyadi,et al.  Vitamin A-fortified monosodium glutamate and health, growth, and survival of children: a controlled field trial. , 1988, The American journal of clinical nutrition.

[16]  A. Sommer,et al.  IMPACT OF VITAMIN A SUPPLEMENTATION ON CHILDHOOD MORTALITY A Randomised Controlled Community Trial , 1986, The Lancet.

[17]  M. M. Patterson,et al.  Statistical programs for the Apple II microcomputer , 1981 .

[18]  K. Aziz,et al.  Failure of a large dose of vitamin A to enhance the antibody response to tetanus toxoid in children. , 1980, The American journal of clinical nutrition.

[19]  Claudia Henry,et al.  Plaque Forming Cells: Methodology and Theory , 1974, Transplantation reviews.

[20]  I. K. Cohen,et al.  Vitamin A: adjuvant and steroid antagonist in the immune response. , 1973, Journal of immunology.

[21]  I. Tannock,et al.  Influence of vitamin A on immunological response. , 1972, Immunology.

[22]  D. Dresser,et al.  Adjuvanticity of Vitamin A , 1968, Nature.

[23]  V. Ramalingaswami.  Nutritional diarrhoea due to vitamin A deficiency. , 1948 .

[24]  L. Sweet,et al.  CLINICAL AND ANATOMIC STUDY OF AVITAMINOSIS A AMONG THE CHINESE , 1935 .