Rapid prototyping of multilayer thermoplastic microfluidic chip

Thermoplastic is a common material in industrial products and it can be applied to microfluidic application since it is much more affordable and stable than PDMS in vary aspects. Based on former studies, a manufacturing process of thermoplastic microfluidic system is proposed, from the feature design to the final microfluidic device. The protocol being proposed is able to achieve rapid prototyping of multilayer thermoplastic microfluidic chips, improve the study efficiency of functional microfluidic product, shorten the period from laboratory to market as well as provide an alternative option for further developing microfluidic commercial products.

[1]  J. Zen,et al.  A new fabrication process for a microchip electrophoresis device integrated with a three‐electrode electrochemical detector , 2005, Electrophoresis.

[2]  Size Effects on Miscibility and Glass Transition Temperature of PS/TMPC Blend Films: a Simulation and Thermodynamic Approach , 2007 .

[3]  S. Franssila,et al.  Free-standing SU-8 microfluidic chips by adhesive bonding and release etching , 2005 .

[4]  G Medoro,et al.  Microfluidic channel fabrication in dry film resist for production and prototyping of hybrid chips. , 2005, Lab on a chip.

[5]  G M Whitesides,et al.  Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. , 2000, Analytical chemistry.

[6]  Qijun Xiao,et al.  Design and fabrication of an electrostatically suspended microgyroscope using UV-LIGA technology , 2009 .

[7]  Holger Becker,et al.  Hot embossing as a method for the fabrication of polymer high aspect ratio structures , 2000 .

[8]  Hui Liu,et al.  Preparation and characterization of polystyrene‐grafted attapulgite via surface‐initiated redox polymerization , 2015 .

[9]  N. Voelcker,et al.  Recent developments in PDMS surface modification for microfluidic devices , 2010, Electrophoresis.

[10]  Roberto Guerrieri,et al.  Dry film resist for fast fluidic prototyping , 2004 .

[11]  R. Masel,et al.  A 3D micromixer fabricated with dry film resist , 2007, IEEE/LEOS International Conference on Optical MEMS.

[12]  P. Renaud,et al.  Polyimide and SU-8 microfluidic devices manufactured by heat-depolymerizable sacrificial material technique. , 2004, Lab on a chip.

[13]  Patrick W. Leech,et al.  Application of dry film resist in the fabrication of microfluidic chips for droplet generation , 2009 .