Caution!! Reappearance of remimazolam effect after a flumazenil bolus: a larger bolus of flumazenil and a lower total remimazolam clearance are higher risks

[1]  K. Masui,et al.  Equilibration rate constant, ke0, to determine effect-site concentration for the Masui remimazolam population pharmacokinetic model in general anesthesia patients , 2022, Journal of Anesthesia.

[2]  K. Masui,et al.  A population pharmacokinetic model of remimazolam for general anesthesia and consideration of remimazolam dose in clinical practice , 2022, Journal of Anesthesia.

[3]  M. Struys,et al.  Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment. , 2021, British journal of anaesthesia.

[4]  Y. Kamiya,et al.  Re-sleeping after reversal of remimazolam by flumazenil , 2021, Journal of Anesthesia.

[5]  R. Soto,et al.  Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER) , 2020, Anesthesiology.

[6]  K. Masui.  Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia!! , 2020, Journal of Anesthesia.

[7]  G. Damm,et al.  Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system , 2019, Drug design, development and therapy.

[8]  J. Smeets,et al.  Assessment of the Potential for Displacement Interactions with Sugammadex , 2012 .

[9]  B. Plaud,et al.  Recurarization after sugammadex reversal in an obese patient , 2011, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[10]  Gavin Kilpatrick,et al.  CNS 7056: A Novel Ultra–short-acting Benzodiazepine , 2007, Anesthesiology.

[11]  J. Proost,et al.  Early Reversal of Profound Rocuronium-induced Neuromuscular Blockade by Sugammadex in a Randomized Multicenter Study: Efficacy, Safety, and Pharmacokinetics , 2007, Anesthesiology.

[12]  D. Stanski,et al.  Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam , 1995, Clinical pharmacology and therapeutics.

[13]  T. Short,et al.  Midazolam and flumazenil pharmacokinetics and pharmacodynamics following simultaneous administration to human volunteers , 1994, Acta anaesthesiologica Scandinavica.

[14]  Z Rattner,et al.  Measurement of Benzodiazepine Receptor Number and Affinity in Humans Using Tracer Kinetic Modeling, Positron Emission Tomography, and [11C]Flumazenil , 1993, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[15]  R. Amrein,et al.  Clinical pharmacology of flumazenil. , 1988, European journal of anaesthesiology. Supplement.