Integrin ligands at a glance

Integrins are one of the major families of cell adhesion receptors ([Humphries, 2000][1]; [Hynes, 2002][2]). All integrins are non-covalently linked, heterodimeric molecules containing an α and a β subunit. Both subunits are type I transmembrane proteins, containing large extracellular domains and

[1]  Richard W. Farndale,et al.  Structural Basis of Collagen Recognition by Integrin α2β1 , 2000, Cell.

[2]  J. Huxley-Jones,et al.  The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family , 2005, BMC Evolutionary Biology.

[3]  A. Aszódi,et al.  Functional consequences of integrin gene mutations in mice. , 2001, Circulation research.

[4]  Thilo Stehle,et al.  Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand , 2002, Science.

[5]  M. Humphries,et al.  Integrin structure. , 2000, Biochemical Society transactions.

[6]  R. Liddington,et al.  Structural basis of collagen recognition by integrin alpha2beta1. , 2000, Cell.

[7]  Junichi Takagi,et al.  Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation , 2003, Cell.

[8]  M. Humphries,et al.  The molecular basis and specificity of integrin-ligand interactions. , 1990, Journal of cell science.

[9]  M. Arnaout,et al.  Integrin structure, allostery, and bidirectional signaling. , 2005, Annual review of cell and developmental biology.

[10]  Barry S. Coller,et al.  Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics , 2004, Nature.

[11]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[12]  T. Springer,et al.  The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. , 2004, Advances in protein chemistry.

[13]  Richard O. Hynes,et al.  The Evolution of Cell Adhesion , 2000, The Journal of cell biology.

[14]  Li Zhang,et al.  Ligand Binding to Integrins* , 2000, The Journal of Biological Chemistry.

[15]  Arnoud Sonnenberg,et al.  Function and interactions of integrins , 2001, Cell and Tissue Research.

[16]  M. Humphries,et al.  The Year 2000 Integrin Model , 2000 .

[17]  N. Brown,et al.  Integrins in development: moving on, responding to, and sticking to the extracellular matrix. , 2002, Developmental cell.