Quantitative methods for developing Fc mutants with extended half-lives.
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Bruce Tidor | Daniel T Kamei | Douglas A Lauffenburger | Bert J Lao | D. Lauffenburger | B. Tidor | R. Deshpande | D. Kamei | Margaret Speed Ricci | M. Ricci | Rohini Deshpande | Han Xu | Han Xu
[1] S L Morrison,et al. Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants. , 1995, Biochemistry.
[2] J. Tso,et al. Engineered Human IgG Antibodies with Longer Serum Half-lives in Primates* , 2004, Journal of Biological Chemistry.
[3] S. Langermann,et al. Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences1 , 2002, The Journal of Immunology.
[4] K. Sharp,et al. Calculating the electrostatic potential of molecules in solution: Method and error assessment , 1988 .
[5] D. Lauffenburger,et al. Receptors: Models for Binding, Trafficking, and Signaling , 1993 .
[6] H. Wiley,et al. Epidermal growth factor stimulates fluid phase endocytosis in human fibroblasts through a signal generated at the cell surface , 1982, Journal of cellular biochemistry.
[7] D. Lauffenburger,et al. Rational cytokine design for increased lifetime and enhanced potency using pH-activated “histidine switching” , 2002, Nature Biotechnology.
[8] E. Ward,et al. Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1. , 1999, Molecular immunology.
[9] P. Nickerson,et al. IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice. , 1999, Journal of immunology.
[10] Jin‐Kyoo Kim,et al. Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptor , 1994, European journal of immunology.
[11] P. Bjorkman,et al. High-affinity binding of the neonatal Fc receptor to its IgG ligand requires receptor immobilization. , 1997, Biochemistry.
[12] J. Deisenhofer. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. , 1981, Biochemistry.
[13] D. Lauffenburger,et al. Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics. , 1998, Chemistry & biology.
[14] M. Simionescu,et al. Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells. , 2001, Human immunology.
[15] J. Baynes,et al. Identification of the sites of IgG catabolism in the rat. , 1982, Archives of biochemistry and biophysics.
[16] Rafael Najmanovich,et al. Protein side‐chain rearrangement in regions of point mutations , 2002, Proteins.
[17] A. West,et al. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,). , 2000, Biochemistry.
[18] W. Lencer,et al. Distribution of the IgG Fc Receptor, FcRn, in the Human Fetal Intestine , 2003, Pediatric Research.
[19] Jin‐Kyoo Kim,et al. Identifying amino acid residues that influence plasma clearance of murine IgG1 fragments by site‐directed mutagenesis , 1994, European journal of immunology.
[20] D. M. Penny,et al. Identification of critical IgG binding epitopes on the neonatal Fc receptor. , 1997, Journal of molecular biology.
[21] Barry Honig,et al. Extending the accuracy limits of prediction for side-chain conformations. , 2001 .
[22] D A Lauffenburger,et al. Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. , 1994, The Journal of biological chemistry.
[23] Jin‐Kyoo Kim,et al. Abnormally short serum half‐lives of IgG in β2‐microglobulin‐deficient mice , 1996, European journal of immunology.
[24] M. Simionescu,et al. Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. , 1998, International immunology.
[25] O. Bakke,et al. Physiological functions of endosomal proteolysis. , 1995, The Biochemical journal.
[26] E. Ward,et al. Multiple roles for the major histocompatibility complex class I- related receptor FcRn. , 2000, Annual review of immunology.
[27] S. L. Mayo,et al. Probing the role of packing specificity in protein design. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[28] Pamela J. Bjorkman,et al. Crystal structure of the complex of rat neonatal Fc receptor with Fc , 1994, Nature.
[29] E. Ward,et al. Transcytosis and catabolism of antibody , 2002, Immunologic research.
[30] S. Fuller,et al. Apical and basolateral endocytosis in Madin‐Darby canine kidney (MDCK) cells grown on nitrocellulose filters. , 1985, The EMBO journal.
[31] P. Bjorkman,et al. Structural basis of pH-dependent antibody binding by the neonatal Fc receptor. , 1998, Structure.
[32] J. Richardson,et al. Asparagine and glutamine: using hydrogen atom contacts in the choice of side-chain amide orientation. , 1999, Journal of molecular biology.
[33] A. West,et al. Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. , 2001, Molecular cell.
[34] T. Blundell,et al. Comparative protein modelling by satisfaction of spatial restraints. , 1993, Journal of molecular biology.
[35] K. Sharp,et al. Accurate Calculation of Hydration Free Energies Using Macroscopic Solvent Models , 1994 .
[36] D A Lauffenburger,et al. Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction (*) , 1995, The Journal of Biological Chemistry.
[37] E. Ward,et al. Catabolism of the Murine IgGl Molecule: Evidence that Both CH2‐CH3 Domain Interfaces are Required for Persistence of IgGl in the Circulation of Mice , 1994 .
[38] Raimund J. Ober,et al. Increasing the serum persistence of an IgG fragment by random mutagenesis , 1997, Nature Biotechnology.
[39] D. Schoenfeld,et al. Increased clearance of IgG in mice that lack β2‐microglobulin: possible protective role of FcRn , 1996, Immunology.
[40] R. Hansen,et al. Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopenia. , 2003, Journal of pharmaceutical sciences.
[41] Alexander D. MacKerell,et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.
[42] Huan-Xiang Zhou,et al. Comparison of calculation and experiment implicates significant electrostatic contributions to the binding stability of barnase and barstar. , 2003, Biophysical journal.
[43] Douglas Lauffenburger,et al. Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects. , 2003, Cancer research.
[44] M. Tanokura,et al. 1H-NMR study on the tautomerism of the imidazole ring of histidine residues. I. Microscopic pK values and molar ratios of tautomers in histidine-containing peptides. , 1983, Biochimica et biophysica acta.
[45] K. Badizadegan,et al. Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. , 1999, The Journal of clinical investigation.
[46] B. Ober,et al. The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn. , 1996, Molecular immunology.
[47] A. Sali,et al. Modeller: generation and refinement of homology-based protein structure models. , 2003, Methods in enzymology.
[48] Raimund J Ober,et al. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans. , 2003, International immunology.