The Genetics of Gilles de la Tourette Syndrome: a Common Aetiological Basis with Comorbid Disorders?

[1]  P. Paschou,et al.  The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery , 2016, Front. Neurosci..

[2]  D. Smit,et al.  Cross-Disorder Genetic Analysis of Tic Disorders, Obsessive–Compulsive, and Hoarding Symptoms , 2016, Front. Psychiatry.

[3]  P. Holmans,et al.  Analysis of Shared Heritability in Common Disorders of the Brain , 2016, bioRxiv.

[4]  C. Mathews,et al.  The relationship between tics, OC, ADHD and autism symptoms: A cross- disorder symptom analysis in Gilles de la Tourette syndrome patients and family-members , 2016, Psychiatry Research.

[5]  A. Fett-Conte,et al.  Single nucleotide polymorphisms in the CNTNAP2 gene in Brazilian patients with autistic spectrum disorder. , 2016, Genetics and molecular research : GMR.

[6]  C. Baker,et al.  Genome Sequencing of Autism-Affected Families Reveals Disruption of Putative Noncoding Regulatory DNA. , 2016, American journal of human genetics.

[7]  H. Lähdesmäki,et al.  The landscape of copy number variations in Finnish families with autism spectrum disorders , 2016, Autism research : official journal of the International Society for Autism Research.

[8]  P. Paschou,et al.  Epigenome-Wide Association Study of Tic Disorders , 2015, Twin Research and Human Genetics.

[9]  Jakob Grove,et al.  Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population , 2015, Nature Genetics.

[10]  Christopher S. Poultney,et al.  Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci , 2015, Neuron.

[11]  K. Safranow,et al.  Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population , 2015, PloS one.

[12]  Z. Tümer,et al.  A mosaic small supernumerary marker chromosome 17 in a patient with Tourette syndrome, ADHD and intellectual disability: A case story and review of the literature , 2015, Psychiatry Research.

[13]  M. Robertson,et al.  Are there distinct subtypes in Tourette syndrome? Pure-Tourette syndrome versus Tourette syndrome-plus, and simple versus complex tics , 2015, Neuropsychiatric disease and treatment.

[14]  J. Sutcliffe,et al.  Analysis of CHRNA7 rare variants in autism spectrum disorder susceptibility , 2015, American journal of medical genetics. Part A.

[15]  W. McMahon,et al.  Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. , 2015, JAMA psychiatry.

[16]  Shiguo Liu,et al.  Do obsessive–compulsive disorder and Tourette syndrome share a common susceptibility gene? An association study of the BDNF Val66Met polymorphism in the Chinese Han population , 2015, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[17]  Z. Tümer,et al.  A t(3;9)(q25.1;q34.3) translocation leading to OLFM1 fusion transcripts in Gilles de la Tourette syndrome, OCD and ADHD , 2015, Psychiatry Research.

[18]  A. Cavanna,et al.  Gilles de la Tourette syndrome and disruptive behavior disorders: prevalence, associations, and explanation of the relationships. , 2015, The Journal of neuropsychiatry and clinical neurosciences.

[19]  Yoav Ben-Shlomo,et al.  Population prevalence of Tourette syndrome: A systematic review and meta‐analysis , 2015, Movement disorders : official journal of the Movement Disorder Society.

[20]  P. Sullivan,et al.  CNV Concordance in 1,097 MZ Twin Pairs , 2015, Twin Research and Human Genetics.

[21]  D. Stephan,et al.  Whole Exome Sequencing in Females with Autism Implicates Novel and Candidate Genes , 2015, International journal of molecular sciences.

[22]  G. Keszler,et al.  Association of the tumor necrosis factor ‐308 A/G promoter polymorphism with Tourette syndrome , 2014, International journal of immunogenetics.

[23]  C. Pittenger,et al.  Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome , 2014, European Neuropsychopharmacology.

[24]  Christopher S. Poultney,et al.  Synaptic, transcriptional, and chromatin genes disrupted in autism , 2014, Nature.

[25]  D. Hoffman,et al.  DPP6 Domains Responsible for Its Localization and Function* , 2014, The Journal of Biological Chemistry.

[26]  J. Scharf,et al.  Genetics of obsessive-compulsive disorder and related disorders. , 2014, The Psychiatric clinics of North America.

[27]  A. Cavanna,et al.  DPP6 gene disruption in a family with Gilles de la Tourette syndrome , 2014, neurogenetics.

[28]  Dan J Stein,et al.  Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. , 2014, Journal of the American Academy of Child and Adolescent Psychiatry.

[29]  P. Paschou,et al.  Genetic association signal near NTN4 in Tourette syndrome , 2014, Annals of neurology.

[30]  D. Pinto,et al.  A CTNNA3 compound heterozygous deletion implicates a role for αT-catenin in susceptibility to autism spectrum disorder , 2014, Journal of Neurodevelopmental Disorders.

[31]  P. Sandor,et al.  Association of the KCNJ5 gene with Tourette Syndrome and Attention‐Deficit/Hyperactivity Disorder , 2014, Genes, brain, and behavior.

[32]  K. Safranow,et al.  The BTBD9 gene polymorphisms in Polish patients with Gilles de la Tourette syndrome. , 2014, Acta neurobiologiae experimentalis.

[33]  L. Corazzini,et al.  Economic Behavior under Alcohol Influence: An Experiment on Time, Risk, and Social Preferences , 2014, SSRN Electronic Journal.

[34]  A. C. Lionel,et al.  Identification of risk genes for autism spectrum disorder through copy number variation analysis in Austrian families , 2014, neurogenetics.

[35]  Zeynep Tümer,et al.  Intragenic deletions affecting two alternative transcripts of the IMMP2L gene in patients with Tourette syndrome , 2014, European Journal of Human Genetics.

[36]  Eden R Martin,et al.  Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders , 2014, Molecular Autism.

[37]  B. Leventhal,et al.  Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice , 2014, Neuron.

[38]  A. Balbi,et al.  Extended Daily Dialysis in Acute Kidney Injury Patients: Metabolic and Fluid Control and Risk Factors for Death , 2013, PloS one.

[39]  Z. Tümer,et al.  Microduplication of 15q13.3 and Xq21.31 in a family with tourette syndrome and comorbidities , 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[40]  Benjamin D. Greenberg,et al.  Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture , 2013, PLoS genetics.

[41]  Seungtai Yoon,et al.  Characterization of SLITRK1 Variation in Obsessive-Compulsive Disorder , 2013, PloS one.

[42]  F. McMahon,et al.  Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder , 2013, Movement disorders : official journal of the Movement Disorder Society.

[43]  M. Nöthen,et al.  Support of the histaminergic hypothesis in Tourette Syndrome: association of the histamine decarboxylase gene in a large sample of families , 2013, Journal of Medical Genetics.

[44]  D. Cath,et al.  Other Psychiatric Comorbidities in Tourette Syndrome , 2013 .

[45]  Y. Worbe,et al.  Pharmacological treatment of Gilles de la Tourette syndrome , 2013, Neuroscience & Biobehavioral Reviews.

[46]  R. Mechelli,et al.  A “Candidate-Interactome” Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis , 2013, PloS one.

[47]  Stephanie E. Vallee,et al.  Investigation of NRXN1 deletions: Clinical and molecular characterization , 2013, American journal of medical genetics. Part A.

[48]  N. Freimer,et al.  CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1 , 2013, PloS one.

[49]  Yiping Shen,et al.  Molecular analysis of a deletion hotspot in the NRXN1 region reveals the involvement of short inverted repeats in deletion CNVs. , 2013, American journal of human genetics.

[50]  Hongyan Wang,et al.  Lack of Association between NLGN3, NLGN4, SHANK2 and SHANK3 Gene Variants and Autism Spectrum Disorder in a Chinese Population , 2013, PloS one.

[51]  H. Hegyi.  GABBR1 has a HERV-W LTR in its regulatory region – a possible implication for schizophrenia , 2013, Biology Direct.

[52]  E. Ginns,et al.  Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes , 2013, European Journal of Human Genetics.

[53]  L. Feuk,et al.  Genome-wide sequencing for the identification of rearrangements associated with Tourette syndrome and obsessive-compulsive disorder , 2012, BMC Medical Genetics.

[54]  L. Su,et al.  Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome , 2012, Psychiatric genetics.

[55]  B. Abrahams,et al.  Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation. , 2012, Human molecular genetics.

[56]  O. Mors,et al.  The Schizophrenia and Bipolar Disorder associated BRD1 gene is regulated upon chronic restraint stress , 2012, European Neuropsychopharmacology.

[57]  A. Rothner,et al.  Headache in children with Tourette syndrome. , 2012, The Journal of pediatrics.

[58]  Margaret A. Pericak-Vance,et al.  Individual common variants exert weak effects on the risk for autism spectrum disorders , 2012, Human molecular genetics.

[59]  P. Paschou,et al.  Replication of association between a SLITRK1 haplotype and Tourette Syndrome in a large sample of families , 2012, Molecular Psychiatry.

[60]  S. E. Stewart,et al.  Genome-wide association study of Tourette Syndrome , 2012, Molecular Psychiatry.

[61]  P. Fitzgerald,et al.  Evidence for Cortical Inhibitory and Excitatory Dysfunction in Obsessive Compulsive Disorder , 2012, Neuropsychopharmacology.

[62]  J. Jankovic,et al.  The genetics of Tourette syndrome , 2012, Nature Reviews Neurology.

[63]  Stephan J Sanders,et al.  Rare Copy Number Variants in Tourette Syndrome Disrupt Genes in Histaminergic Pathways and Overlap with Autism , 2012, Biological Psychiatry.

[64]  G. Kitas,et al.  Imaging modalities for the diagnosis of pulmonary hypertension in systemic sclerosis , 2012, Nature Reviews Rheumatology.

[65]  L. Su,et al.  Mutation screening of the HDC gene in Chinese Han patients with Tourette syndrome , 2012, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[66]  D. Schroeder,et al.  15q11.2-13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain. , 2011, Human molecular genetics.

[67]  Carlos S. Moreno,et al.  Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenotypes , 2011, PLoS genetics.

[68]  Stephen J. Guter,et al.  A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder , 2011, Human Genetics.

[69]  Dai Zhang,et al.  Evidence for association between Disrupted-in-schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study , 2011, Behavioral and Brain Functions.

[70]  M. Behen,et al.  Exome sequencing of a pedigree with tourette syndrome or chronic tic disorder , 2011, Annals of neurology.

[71]  H. Singer,et al.  Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome , 2011, Psychiatric genetics.

[72]  J. Morton,et al.  Translocation breakpoint at 7q31 associated with tics: further evidence for IMMP2L as a candidate gene for Tourette syndrome , 2011, European Journal of Human Genetics.

[73]  Matthew W State,et al.  The Genetics of Child Psychiatric Disorders: Focus on Autism and Tourette Syndrome , 2010, Neuron.

[74]  Jiannis Ragoussis,et al.  Characterization of a Family with Rare Deletions in CNTNAP5 and DOCK4 Suggests Novel Risk Loci for Autism and Dyslexia , 2010, Biological Psychiatry.

[75]  M. Grados.  The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery. , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.

[76]  Daniel J. White,et al.  Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate. , 2010, Psychiatric genetics.

[77]  W. Krenz,et al.  Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade. , 2010, Journal of neurophysiology.

[78]  Judy H. Cho,et al.  L-histidine decarboxylase and Tourette's syndrome. , 2010, The New England journal of medicine.

[79]  M. Tohyama,et al.  DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth , 2010, Molecular Psychiatry.

[80]  H. Chugani,et al.  Tourette syndrome is associated with recurrent exonic copy number variants , 2010, Neurology.

[81]  H. Peeters,et al.  DISC1 duplication in two brothers with autism and mild mental retardation , 2010, Clinical genetics.

[82]  H. Möller,et al.  A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome , 2010, Psychiatric genetics.

[83]  Thomas Haaf,et al.  Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder , 2010, neurogenetics.

[84]  D. Gilbert,et al.  Tourette Syndrome and Klippel-Feil Anomaly in a Child with Chromosome 22q11 Duplication , 2009, Case reports in medicine.

[85]  F. Richer,et al.  Association of intronic variants of the BTBD9 gene with Tourette syndrome. , 2009, Archives of neurology.

[86]  Kate D. Meyer,et al.  Disc1 regulates granule cell migration in the developing hippocampus. , 2009, Human molecular genetics.

[87]  S. Cheung,et al.  A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder , 2009, American journal of medical genetics. Part A.

[88]  Joseph T. Glessner,et al.  Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes , 2009, Molecular Psychiatry.

[89]  Paul Sandor,et al.  Association of SLITRK1 to Gilles de la Tourette Syndrome , 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[90]  K Allen-Brady,et al.  Genome-wide linkage in Utah autism pedigrees , 2009, Molecular Psychiatry.

[91]  Tomi D. Berney,et al.  High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L–DOCK4 gene region in autism susceptibility , 2009, Molecular Psychiatry.

[92]  P. Thuras,et al.  Expression of GABAB Receptors Is Altered in Brains of Subjects with Autism , 2009, The Cerebellum.

[93]  F. Riederer,et al.  Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder , 2008, Psychiatric genetics.

[94]  Ju Young Kim,et al.  Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain , 2008, Proceedings of the National Academy of Sciences.

[95]  B. Rudy,et al.  DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein , 2008, Frontiers in molecular neuroscience.

[96]  S. Sommer,et al.  Familial deletion within NLGN4 associated with autism and Tourette syndrome , 2008, European Journal of Human Genetics.

[97]  N. Hattori,et al.  PARK9-LINKED PARKINSONISM IN EASTERN ASIA: MUTATION DETECTION IN ATP13A2 AND CLINICAL PHENOTYPE , 2008, Neurology.

[98]  C. Bishop,et al.  A Mutation in the Inner Mitochondrial Membrane Peptidase 2-Like Gene (Immp2l) Affects Mitochondrial Function and Impairs Fertility in Mice1 , 2008, Biology of reproduction.

[99]  D. Pinto,et al.  Structural variation of chromosomes in autism spectrum disorder. , 2008, American journal of human genetics.

[100]  T Varilo,et al.  Association of DISC1 with autism and Asperger syndrome , 2008, Molecular Psychiatry.

[101]  F. Tsai,et al.  Association of the Slit and Trk-like 1 gene in Taiwanese patients with Tourette syndrome. , 2007, Pediatric neurology.

[102]  D. Murphy,et al.  A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. , 2007, Human molecular genetics.

[103]  Xin Duan,et al.  Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain , 2007, Cell.

[104]  K. Müller-Vahl,et al.  Role of the novel tryptophan hydroxylase-2 gene in Tourette syndrome , 2007, Molecular Psychiatry.

[105]  J. Leckman,et al.  Frontal dopaminergic abnormality in Tourette syndrome: A postmortem analysis , 2007, Journal of the Neurological Sciences.

[106]  P. Asherson,et al.  Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples , 2007, BMC psychiatry.

[107]  J. Jankovic,et al.  Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome , 2006, Acta neurologica Scandinavica.

[108]  D. Blackwood,et al.  Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder , 2006, Molecular Psychiatry.

[109]  S. E. Stewart,et al.  A controlled family study of attention-deficit/hyperactivity disorder and Tourette's disorder. , 2006, Journal of the American Academy of Child and Adolescent Psychiatry.

[110]  M. Cuccaro,et al.  SLITRK1 mutations in trichotillomania , 2006, Molecular Psychiatry.

[111]  David Goldman,et al.  Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. , 2006, American journal of human genetics.

[112]  Christopher A. Ross,et al.  A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development , 2005, Nature Cell Biology.

[113]  Murat Gunel,et al.  Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome , 2005, Science.

[114]  M. DiFiglia,et al.  Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[115]  D. Vaux,et al.  Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. , 2005, Molecular biology of the cell.

[116]  F. Richer,et al.  Association between 7q31 markers and tourette syndrome , 2004, American journal of medical genetics. Part A.

[117]  F. Richer,et al.  Tourette syndrome and dopaminergic genes: a family-based association study in the French Canadian founder population , 2004, Molecular Psychiatry.

[118]  J. Jankovic,et al.  Migraine headache in patients with Tourette syndrome. , 2003, Archives of neurology.

[119]  P. Heutink,et al.  CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. , 2003, Genomics.

[120]  Heping Zhang,et al.  Basal Ganglia volumes in patients with Gilles de la Tourette syndrome. , 2003, Archives of general psychiatry.

[121]  C. Windpassinger,et al.  Candidate region for Gilles de la Tourette syndrome at 7q31. , 2001, American journal of medical genetics.

[122]  S. Scherer,et al.  Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. , 2001, American journal of human genetics.

[123]  Paul Sandor,et al.  An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries , 2000, Developmental medicine and child neurology.

[124]  H. Nicolini,et al.  Increased prevalence of the seven-repeat variant of the dopamine D4 receptor gene in patients with obsessive-compulsive disorder with tics , 1997, Neuroscience Letters.

[125]  D. Palumbo,et al.  Hypothesis III. Tourette syndrome is only one of several causes of a developmental basal ganglia syndrome. , 1997, Archives of neurology.

[126]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[127]  D. Comings,et al.  Tourette syndrome in a pedigree with a 7;18 translocation: identification of a YAC spanning the translocation breakpoint at 18q22.3. , 1996, American journal of human genetics.

[128]  D. Comings,et al.  Polygenic inheritance of Tourette syndrome, stuttering, attention deficit hyperactivity, conduct, and oppositional defiant disorder: the additive and subtractive effect of the three dopaminergic genes--DRD2, D beta H, and DAT1. , 1996, American journal of medical genetics.

[129]  D. Comings,et al.  A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient. , 1996, Biochemical and biophysical research communications.

[130]  W. Matthews,et al.  Tourette's syndrome and migraine. , 1984, Archives of neurology.

[131]  M. Robertson.  A personal 35 year perspective on Gilles de la Tourette syndrome: assessment, investigations, and management. , 2015, The lancet. Psychiatry.

[132]  M. Robertson.  A personal 35 year perspective on Gilles de la Tourette syndrome: prevalence, phenomenology, comorbidities, and coexistent psychopathologies. , 2015, The lancet. Psychiatry.

[133]  S. E. Stewart,et al.  Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. , 2015, The American journal of psychiatry.

[134]  D. Toncheva,et al.  Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism. , 2012, Genetic counseling.

[135]  M. Grados,et al.  Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample. , 2011, Journal of the American Academy of Child and Adolescent Psychiatry.

[136]  S. Scherer,et al.  Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome , 2006, Molecular Genetics and Genomics.

[137]  M. Orth,et al.  Behavioral and affective disorders in Tourette syndrome. , 2006, Advances in neurology.

[138]  M Tohyama,et al.  Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth , 2003, Molecular Psychiatry.

[139]  D. Comings,et al.  Correlation of length of VNTR alleles at the X-linked MAOA gene and phenotypic effect in Tourette syndrome and drug abuse , 1998, Molecular Psychiatry.

[140]  J. Leckman,et al.  A family study of Gilles de la Tourette syndrome. , 1991, American journal of human genetics.

[141]  P. Paschou.  Author's Personal Copy Neuroscience and Biobehavioral Reviews the Genetic Basis of Gilles De La Tourette Syndrome , 2022 .