Post‐dialysis fatigue and serum S100B protein in patients on chronic hemodialysis. A pilot study

Aim of the present study was to assess whether post‐dialysis fatigue (PDF) may be related to pre‐ or post‐dialysis levels of serum S100B protein. Hemodialysis patients (HD) who answered to be fatigued after their hemodialysis sessions when asked: “Do you feel worse after dialysis? if they answered yes” were considered to suffer from PDF. Serum Interleukins (IL‐1β, IL‐6, IL‐10), TNF‐α and S100B were assessed by ELISA kit.

[1]  M. Balconi,et al.  Fatigue and apathy in patients on chronic hemodialysis , 2021, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

[2]  C. V. van Heugten,et al.  mHealth-based experience sampling method to identify fatigue in the context of daily life in haemodialysis patients , 2020, Clinical kidney journal.

[3]  J. Rungby,et al.  Blood-brain barrier pathology in patients with severe mental disorders: a systematic review and meta-analysis of biomarkers in case-control studies , 2020, Brain, behavior, & immunity - health.

[4]  D. Wolfgram Intradialytic Cerebral Hypoperfusion as Mechanism for Cognitive Impairment in Patients on Hemodialysis. , 2019, Journal of the American Society of Nephrology : JASN.

[5]  P. Ruoff,et al.  Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome , 2019, Journal of Neuroinflammation.

[6]  C. V. van Heugten,et al.  Exploring the Diurnal Course of Fatigue in Patients on Hemodialysis Treatment and Its Relation With Depressive Symptoms and Classical Conditioning. , 2019, Journal of pain and symptom management.

[7]  P. Jonsson,et al.  Air contamination during medical treatment results in deposits of microemboli in the lungs: An autopsy study , 2019, The International journal of artificial organs.

[8]  C. Hutchison,et al.  Large uremic toxins: an unsolved problem in end-stage kidney disease , 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[9]  L. Tarassenko,et al.  Relationship between Hypotension and Cerebral Ischemia during Hemodialysis. , 2017, Journal of the American Society of Nephrology : JASN.

[10]  J. Lasselin,et al.  Role of Inflammation in Human Fatigue: Relevance of Multidimensional Assessments and Potential Neuronal Mechanisms , 2017, Front. Immunol..

[11]  R. Detels,et al.  Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions. , 2016, Cytokine.

[12]  M. Bossola,et al.  Postdialysis Fatigue: A Frequent and Debilitating Symptom , 2016, Seminars in dialysis.

[13]  M. Bossola,et al.  Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. , 2015, Journal of pain and symptom management.

[14]  M. Bossola,et al.  Variables associated with time of recovery after hemodialysis. , 2013, Journal of nephrology.

[15]  Jwa-Kyung Kim,et al.  Serum S100B protein is associated with depressive symptoms in patients with end-stage renal disease. , 2012, Clinical biochemistry.

[16]  L. Saligan,et al.  A systematic review of the association between immunogenomic markers and cancer-related fatigue , 2012, Brain, Behavior, and Immunity.

[17]  M. Vizcaychipi,et al.  Central nervous system inflammation in disease related conditions: Mechanistic prospects , 2012, Brain Research.

[18]  R. Omdal,et al.  Biological mechanisms of chronic fatigue. , 2011, Rheumatology.

[19]  J. Bazarian,et al.  Extracranial Sources of S100B Do Not Affect Serum Levels , 2010, PloS one.

[20]  B. Bogerts,et al.  S100B serum levels are closely correlated with body mass index: An important caveat in neuropsychiatric research , 2010, Psychoneuroendocrinology.

[21]  B. Bogerts,et al.  A New Pathophysiological Aspect of S100B in Schizophrenia: Potential Regulation of S100B by Its Scavenger Soluble RAGE , 2009, Biological Psychiatry.

[22]  F. Brozzi,et al.  S100B's double life: intracellular regulator and extracellular signal. , 2009, Biochimica et biophysica acta.

[23]  H. Abdul-Khaliq,et al.  S100B modulates IL-6 release and cytotoxicity from hypothermic brain cells and inhibits hypothermia-induced axonal outgrowth , 2007, Neuroscience Research.

[24]  A. Garg,et al.  Minutes to recovery after a hemodialysis session: a simple health-related quality of life question that is reliable, valid, and sensitive to change. , 2006, Clinical journal of the American Society of Nephrology : CJASN.

[25]  S. Robinson,et al.  TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer’s disease , 2006, Journal of Neural Transmission.

[26]  M. Genovese,et al.  Effect of etanercept on fatigue in patients with recent or established rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[27]  S. Gold,et al.  Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour? , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[28]  G. Jullien,et al.  Therapeutic application of the molecular adsorbent recirculating system in chronic severe hepatitis patients complicated with multiorgan failure , 2005, Critical Care.

[29]  P. Stenvinkel,et al.  Inflammation as a cause of malnutrition, atherosclerotic cardiovascular disease, and poor outcome in hemodialysis patients , 2004, Hemodialysis international. International Symposium on Home Hemodialysis.

[30]  F. Weber,et al.  Cytokine mRNA expression in patients with multiple sclerosis and fatigue , 2004, Multiple sclerosis.

[31]  G. Kaysen The microinflammatory state in uremia: causes and potential consequences. , 2001, Journal of the American Society of Nephrology : JASN.

[32]  R. Donato,et al.  S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. , 2001, The international journal of biochemistry & cell biology.

[33]  R. Dantzer Cytokine‐Induced Sickness Behavior: Mechanisms and Implications , 2001, Annals of the New York Academy of Sciences.

[34]  A. Sklar,et al.  Identification of factors responsible for postdialysis fatigue. , 1999, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[35]  D. Beezhold,et al.  Postdialysis fatigue: lack of effect of a biocompatible membrane. , 1998, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[36]  B. Fernhall,et al.  Microemboli , developed during haemodialysis , pass the lung barrier and may cause ischaemic lesions in organs such as the brain , 2010 .

[37]  R. Dantzer,et al.  From inflammation to sickness and depression: when the immune system subjugates the brain , 2008, Nature Reviews Neuroscience.

[38]  M. Cavaglià,et al.  Peripheral markers of brain damage and blood-brain barrier dysfunction. , 2003, Restorative neurology and neuroscience.

[39]  H. Joller,et al.  S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. , 2001, Journal of neurotrauma.

[40]  L A Riesenberg,et al.  Postdialysis fatigue. , 1996, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[41]  D. Falkenhagen,et al.  Sterile and endotoxin free dialysis fluid for hemodialysis. , 1991, Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.